Bone morphogenetic protein-3b (BMP-3b) gene expression is correlated with differentiation in rat calvarial osteoblasts.

abstract：:Aurora-C, a member of the Aurora kinase family, is implicated in the regulation of mitosis. In contrast to Aurora-A and Aurora-B its cellular localization and functions are poorly characterized. TACC1 protein belongs to the transforming acidic coiled-coil family shown to interact with the Aurora kinases. In the presen...

journal_title：Biochemical and biophysical research communications

authors： Gabillard JC,Ulisse S,Baldini E,Sorrenti S,Cremet JY,Coccaro C,Prigent C,D'Armiento M,Arlot-Bonnemains Y

更新日期：2011-05-20 00:00:00

abstract：:Variations in the UDP-glucuronosyltransferase (UGT) 1A7 gene have been found to be related to the development of hepatocellular carcinoma (HCC). Since the pathogenesis of liver cirrhosis is not dissimilar to that of HCC, we hypothesized that UGT1A7 genetic polymorphisms may be associated with liver cirrhosis. PCR-rest...

journal_title：Biochemical and biophysical research communications

authors： Tang KS,Lee CM,Teng HC,Huang MJ,Huang CS

更新日期：2008-02-15 00:00:00

abstract：:Different progestogens are widely used in hormonal therapy and mediate their therapeutic actions via the progesterone receptor (PR). Little published data exist on their relative efficacies and potencies via the PR, while those available may be confounded by off-target receptors, different methodologies and model syst...

journal_title：Biochemical and biophysical research communications

authors： Enfield K,Cartwright M,Toit RL,Avenant C,Africander D,Hapgood JP

更新日期：2020-12-17 00:00:00

abstract：:The bridging element for electron transfer in proteins is the hydrogen bond according to the new experimental perspective in preference to carbon-carbon σ-bond presently used. The purpose of this study is to identify an alternative pathway linked by hydrogen bonds suitable for electron transfer from heme-Fe of cytochr...

journal_title：Biochemical and biophysical research communications

authors： Ramasarma T,Vaigundan D

更新日期：2018-10-28 00:00:00

abstract：:The products of the TSC1 (hamartin) and TCS2 (tuberin) tumor suppressor genes negatively regulate cell growth by inhibiting mTOR signaling. Recent research has led to the postulation that tuberin and/or hamartin are involved in tumor migration, presumably through Rho activation. Here we show that LEF-8 cells, which co...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Das SK,Inoue H,Kazami M,Hino O,Kobayashi T,Yeung RS,Kobayashi K,Tadokoro T,Yamamoto Y

更新日期：2008-03-28 00:00:00

abstract：:Bradykinin (BK) B2 receptor signaling involves activation of phospholipase C (PLC). PLC activation by other receptors consists of either allosteric activation of PLC beta isoforms by G-proteins or tyrosine phosphorylation of PLC gamma isoforms. Because the B2 receptor is a G-protein-coupled receptor, it has been assum...

journal_title：Biochemical and biophysical research communications

authors： Venema VJ,Ju H,Sun J,Eaton DC,Marrero MB,Venema RC

更新日期：1998-05-08 00:00:00

abstract：:Lung fibrosis is a common and serious complication of radiation therapy for lung cancer, for which there are no efficient treatments. Emerging evidence indicates that lysophosphatidic acid (LPA) and its receptors (LPARs) are involved in the pathogenesis of fibrosis. Here, we reported that thoracic radiation with 16Gy ...

journal_title：Biochemical and biophysical research communications

authors： Gan L,Xue JX,Li X,Liu DS,Ge Y,Ni PY,Deng L,Lu Y,Jiang W

更新日期：2011-05-27 00:00:00

abstract：:Isovalerylcarnitine, a product of the catabolism of L-leucine, is a potent activator of rat calpains isolated from erythrocytes, kidney, liver, skeletal and heart muscle. Only calpains II, but not calpains I, are activated by IVC, with the only exception of rat erythrocyte calpain I, the only species present in these ...

journal_title：Biochemical and biophysical research communications

authors： Pontremoli S,Melloni E,Viotti PL,Michetti M,Di Lisa F,Siliprandi N

更新日期：1990-02-28 00:00:00

abstract：:The ras family of oncogenes, as well as the transplasma membrane electron transport system, have been implicated in cellular growth control. Here we present evidence that the Ha-ras oncoprotein increases the activity of the transplasma membrane electron transport system in the mouse embryonic fibroblast cell line C3H1...

journal_title：Biochemical and biophysical research communications

authors： Crowe RA,Taparowsky EJ,Crane FL

更新日期：1993-10-29 00:00:00

abstract：:Vascular calcification increases the risk of developing cardiovascular disease, and it is closely associated with metabolic disorders such as diabetes mellitus and non-alcoholic fatty liver disease. We investigated whether the activators of AMP-activated protein kinase (AMPK), metformin, resveratrol, and exendin-4, im...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Hong SW,Kim MJ,Kwon H,Park SE,Rhee EJ,Lee WY

更新日期：2020-09-17 00:00:00

abstract：:A series of C-terminal linear peptides of endothelin (ET)-1 and their N alpha-succinyl (Suc) analogs were synthesized and their binding affinities for the two subtypes of ET receptor, ETA and ETB, in porcine lung membranes were examined. Among the synthetic analogs, Suc-[Glu9,Ala11,15]-ET-1(8-21), IRL 1620, was the mo...

journal_title：Biochemical and biophysical research communications

authors： Takai M,Umemura I,Yamasaki K,Watakabe T,Fujitani Y,Oda K,Urade Y,Inui T,Yamamura T,Okada T

更新日期：1992-04-30 00:00:00

abstract：:Using an anti-serum against synthetic alpha-inhibin-31, we have studied its cellular locations in rodent testis and brain. Western blot analysis detected several molecular forms of the protein(s). A protein of 17 KDa in size was detected in testis of one month old mice. Two major bands of molecular weights 39 kDA and ...

journal_title：Biochemical and biophysical research communications

authors： Lau YF,Li CH

更新日期：1987-05-29 00:00:00

abstract：:Autophagy has been implicated in several neurodegenerative diseases and recently its role in acute brain injury has received increased interest. In our study, we investigated the profiles of autophagy-linked proteins (MAP-LC3 (Atg8), beclin-1 (Atg6) and the beclin-1-binding protein, bcl-2, following controlled cortica...

journal_title：Biochemical and biophysical research communications

authors： Sadasivan S,Dunn WA Jr,Hayes RL,Wang KK

更新日期：2008-09-05 00:00:00

abstract：:Antiserum prepared against the denatured form of mammalian malate dehydrogenase was found to immunoprecipitate the denatured but not the native form of the mature enzyme. In contrast, the antiserum immunoprecipitated the enzyme's precursor, synthesized in a rabbit reticulocyte lysate, either before or after denaturati...

journal_title：Biochemical and biophysical research communications

authors： Chien SM,Freeman KB

更新日期：1986-11-26 00:00:00

abstract：:The thrombopoietin receptor, also known as c-Mpl, is a member of the cytokine superfamily, which regulates the differentiation of megakaryocytes and formation of platelets by binding to its ligand, thrombopoietin (TPO), through Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. The l...

journal_title：Biochemical and biophysical research communications

authors： Sasazawa Y,Sato N,Suzuki T,Dohmae N,Simizu S

更新日期：2015-12-04 00:00:00

abstract：:Plasmodium vivax malaria is one of the most prevalent parasitic diseases in Asia and Latin-America. The difficulty of maintaining this parasite culture in vitro has hampered identifying and characterising proteins implied in merozoite invasion of red blood cells. We have been able to identify an open reading frame in ...

journal_title：Biochemical and biophysical research communications

authors： Perez-Leal O,Sierra AY,Barrero CA,Moncada C,Martinez P,Cortes J,Lopez Y,Salazar LM,Hoebeke J,Patarroyo MA

更新日期：2005-06-17 00:00:00

abstract：:Endothelin (200 nM) evoked a rapid rise in [Ca2+]i which was then followed by a maintained elevation of [Ca2+]i. The initial transient can be explained by the release of stored Ca2+ whilst the maintained plateau is likely to be an influx of Ca2+ as it was partially inhibited by nifedipine (5 microM) and the remaining ...

journal_title：Biochemical and biophysical research communications

authors： Simpson AW,Ashley CC

更新日期：1989-09-29 00:00:00

abstract：:Store-operated Ca(2+) entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using ...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Shiota M,Ohkawa Y,Baba A,Wanibuchi H,Kinashi T,Kurosaki T,Baba Y

更新日期：2012-06-15 00:00:00

abstract：:To develop a non-invasive and sensitive diagnostic test for cancer using peripheral blood, we evaluated gene expression profiling of blood obtained from patients with cancer of the digestive system and normal subjects. The expression profiles of blood-derived total RNA obtained from 39 cancer patients (11 colon cancer...

journal_title：Biochemical and biophysical research communications

authors： Honda M,Sakai Y,Yamashita T,Yamashita T,Sakai A,Mizukoshi E,Nakamoto Y,Tatsumi I,Miyazaki Y,Tanno H,Kaneko S,Hokuriku Liver Study Group.

更新日期：2010-09-10 00:00:00

abstract：:A GSH-dependent dehydroascorbate reductase (EC 1.8.5.1) was purified to homogeneity from human erythrocytes. The enzyme was a monomer of 32 kDa and was purified 133-fold from a crude DEAE-Sepharose fraction with a 25% yield. The reduced protein had a pI of 5.1 as judged by isoelectric focusing. Kinetic analysis gave a...

journal_title：Biochemical and biophysical research communications

authors： Xu DP,Washburn MP,Sun GP,Wells WW

更新日期：1996-04-05 00:00:00

abstract：:The Ca(2+)-binding S100A1 protein displays a specific and high expression level in the human myocardium and is considered to be an important regulator of heart contractility. Diminished protein levels detected in dilated cardiomyopathy possibly contribute to impaired Ca(2+) handling and contractility in heart failure....

journal_title：Biochemical and biophysical research communications

authors： Kiewitz R,Acklin C,Schäfer BW,Maco B,Uhrík B,Wuytack F,Erne P,Heizmann CW

更新日期：2003-06-27 00:00:00

abstract：:This study examines the effect of TNFα on whole bovine intervertebral discs in organ culture and its association with changes characteristic of intervertebral disc degeneration (IDD) in order to inform future treatments to mitigate the chronic inflammatory state commonly found with painful IDD. Pro-inflammatory cytoki...

journal_title：Biochemical and biophysical research communications

authors： Purmessur D,Walter BA,Roughley PJ,Laudier DM,Hecht AC,Iatridis J

更新日期：2013-03-29 00:00:00

abstract：:S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and l-homocysteine. This enzyme is frequently overexpressed in many tumor types and is considered to be a validated anti-tumor target. In order to enable the development of small molecule AHCY inhib...

journal_title：Biochemical and biophysical research communications

authors： Uchiyama N,Dougan DR,Lawson JD,Kimura H,Matsumoto SI,Tanaka Y,Kawamoto T

更新日期：2017-09-09 00:00:00

abstract：:The production of IL-8 can be induced by LPS via TLR4 signaling pathway. In this study, we tested the effect of a herbal melanin (HM) extract, from black cumin seeds (Nigella sativa L.), on IL-8 production. We used HM and LPS in parallel to induce IL-8 production by THP-I, PBMCs, and TLR4-transfected HEK293 cells. Bot...

journal_title：Biochemical and biophysical research communications

authors： El-Obeid A,Hassib A,Pontén F,Westermark B

更新日期：2006-06-16 00:00:00

abstract：:The current utility of bioluminescence imaging is constrained by a low photon yield that limits temporal sensitivity. Here, we describe an imaging method that uses a chemiluminescent/fluorescent protein, ffLuc-cp156, which consists of a yellow variant of Aequorea GFP and firefly luciferase. We report an improvement in...

journal_title：Biochemical and biophysical research communications

authors： Hara-Miyauchi C,Tsuji O,Hanyu A,Okada S,Yasuda A,Fukano T,Akazawa C,Nakamura M,Imamura T,Matsuzaki Y,Okano HJ,Miyawaki A,Okano H

更新日期：2012-03-09 00:00:00

abstract：:Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation ...

journal_title：Biochemical and biophysical research communications

authors： Ni B,Farrar JS,Chen S,Lownik JC,Celi FS

更新日期：2018-07-02 00:00:00

abstract：:A protein of Mr 16,000 (protein 16 K) which tightly binds to DNA has been isolated from E. coli. The amino acid composition and amino-terminal amino acid sequence of this protein have been determined. On the basis of its physico-chemical characteristics the protein 16 K was shown to be identical to the protein H1 [Cuk...

journal_title：Biochemical and biophysical research communications

authors： Laine B,Sautiere P,Spassky A,Rimsky S

更新日期：1984-03-30 00:00:00

abstract：:Human follitropin receptor (hFSHR) cDNA was inserted into the genome of Autographa californica nuclear polyhedrosis virus under the control of the polyhedrin promoter. Spodoptera frugiperda (Sf9) insect cells expressed the hFSHR at the membrane level, 2-3 days after infection. Ligand binding analysis demonstrated satu...

journal_title：Biochemical and biophysical research communications

authors： Christophe S,Robert P,Maugain S,Bellet D,Koman A,Bidart JM

更新日期：1993-10-15 00:00:00

abstract：:The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selective anti-herpes-virus compound. In order to synthesize and study the properties of a DNA that contains C-BVDU, the 5'-triphosphate, C-BVDUTP was prepared and evaluated as a potential substrate of the E. coli Klenow DNA...

journal_title：Biochemical and biophysical research communications

authors： Sági J,De Clercq E,Szemzö A,Csárnyi A,Kovács T,Otvös L

更新日期：1987-09-30 00:00:00

abstract：:Standardized RT-PCR (StaRT-PCR) enables numerical quantification as well as intra- and inter-laboratory comparison of gene expression. Multiplex StaRT-PCR, using two rounds of amplification, was conducted on Stratagene Universal Reference RNA. In the first round, cDNA, competitive template (CT) mix, and primers for up...

journal_title：Biochemical and biophysical research communications

authors： Crawford EL,Warner KA,Khuder SA,Zahorchak RJ,Willey JC

更新日期：2002-04-26 00:00:00