Dystroglycan depletion inhibits the functions of differentiated HL-60 cells.

abstract：:High circulating levels of anti-endothelial antibodies have been reported in patients with accelerated transplant coronary artery disease (TxCAD); however, the nature or characteristics of the antigen to which these antibodies bind in vivo remain unclear. To identify the antigen, a human endothelial cell cDNA expressi...

journal_title：Biochemical and biophysical research communications

authors： Ationu A,Collins A

更新日期：1997-07-30 00:00:00

abstract：BACKGROUND:Membrane protrusions play important roles in biological processes such as cell adhesion, wound healing, migration, and sensing of the external environment. Cell protrusions are a subtype of membrane microdomains composed of cholesterol and sphingolipids, and can be disrupted by cholesterol depletion. Promini...

journal_title：Biochemical and biophysical research communications

authors： Singh RD,Schroeder AS,Scheffer L,Holicky EL,Wheatley CL,Marks DL,Pagano RE

更新日期：2013-05-10 00:00:00

abstract：:We examined the effect of low density lipoprotein (LDL) on histamine release from purified human lung mast cells. LDL inhibited anti-IgE- induced histamine release in a dose-dependent manner, with 100 micrograms/ml LDL-protein inhibiting histamine release by 53 +/- 8% (mean +/- SEM); half-maximal inhibition occurred a...

journal_title：Biochemical and biophysical research communications

authors： Schulman ES,Quinn TJ,Post TJ,O'Donnell P,Rodriguez A,Gonen B

更新日期：1987-10-29 00:00:00

abstract：:GA733 is a murine IgG2a monoclonal antibody (MAb) against human gastric carcinoma and is highly tumoricidal in nude mice. The GA733 antigen is a cell surface protein with two subunits of 30,000 and 40,000 daltons. The antigen isolated by immunoaffinity chromatography consists mainly of the 30,000-dalton subunit which ...

journal_title：Biochemical and biophysical research communications

authors： Ross AH,Herlyn D,Iliopoulos D,Koprowski H

更新日期：1986-02-26 00:00:00

abstract：:The natural compound ferulenol, a sesquiterpene prenylated coumarin derivative, was purified from Ferula vesceritensis and its mitochondrial effects were studied. Ferulenol caused inhibition of oxidative phoshorylation. At low concentrations, ferulenol inhibited ATP synthesis by inhibition of the adenine nucleotide tr...

journal_title：Biochemical and biophysical research communications

authors： Lahouel M,Zini R,Zellagui A,Rhouati S,Carrupt PA,Morin D

更新日期：2007-03-30 00:00:00

abstract：:Hammerhead ribozymes may be of great therapeutic importance, since they can, in theory, be developed to cleave any undesired target RNA. In order to design ribozymes which are stable against endogenous RNases, we incorporated 2'-acetamido-2'-deoxynucleosides in the catalytic core of a hammerhead ribozyme. The 2'-aceta...

journal_title：Biochemical and biophysical research communications

authors： Hendrix C,Mahieu M,Anné J,Van Calenbergh S,Van Aerschot A,Content J,Herdewijn P

更新日期：1995-05-05 00:00:00

abstract：:Parathyroid hormone (PTH) significantly affects osteoblast function by altering gene expression. We have identified neuron-derived orphan receptor-1 (NOR-1) as a PTH-induced primary gene in osteoblastic cells. NOR-1, Nurr1, and Nur77 comprise the NGFI-B nuclear orphan receptor family and Nurr1 and Nur77 are PTH-induce...

journal_title：Biochemical and biophysical research communications

authors： Pirih FQ,Nervina JM,Pham L,Aghaloo T,Tetradis S

更新日期：2003-06-20 00:00:00

abstract：:Previous studies have shown that human rhabdomyosarcoma cells are induced to differentiate by TPA, in the absence of appreciable alterations of the muscle regulatory genes and their products (1). The question was addressed whether the tumor suppressor p53 could be a target of TPA action in these cells. Genomic analysi...

journal_title：Biochemical and biophysical research communications

authors： Germani A,Fusco C,Martinotti S,Musarò A,Molinaro M,Zani BM

更新日期：1994-07-15 00:00:00

abstract：:Exposure to silica has been associated with progressive pulmonary inflammation and fibrosis. While the fibroblasts play an important role in the pathogenesis of silicosis, the direct interaction between silica and fibroblasts is poorly understood. We observed that silica particles stimulated intracellular ROS generati...

journal_title：Biochemical and biophysical research communications

authors： Cho YJ,Seo MS,Kim JK,Lim Y,Chae G,Ha KS,Lee KH

更新日期：1999-09-07 00:00:00

abstract：:Special AT-rich sequence-binding protein (SATB) plays a critical role in bone generation and osteoblast differentiation. In the present study, the differentially expressed genes by SATB2 overexpression were analyzed in MC3T3-E1 osteoblast-like cells using Alizarin red S staining, wound healing assay and Agilent's Huma...

journal_title：Biochemical and biophysical research communications

authors： Kim IS,Jeong SJ,Kim SH,Jung JH,Park YG,Kim SH

更新日期：2012-01-13 00:00:00

abstract：:Recent structural investigations on the beta-1,4-galactosyltransferase-1 (Gal-T1) and lactose synthase (LS) have revealed that they are akin to an exquisite mechanical device with two well-coordinated flexible loops that are contained within the Gal-T1 catalytic domain. The smaller one has a Trp residue (Trp314) flank...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishnan B,Boeggeman E,Qasba PK

更新日期：2002-03-15 00:00:00

abstract：:Caspase-8 is a key mediator in various biological processes such as apoptosis, necroptosis, inflammation, T/B cells activation, and cell motility. Caspase-8 is characterized by the N-terminal tandem death effector domains (DEDs) and the C-terminal catalytic protease domain. The DEDs mediate diverse functions of caspas...

journal_title：Biochemical and biophysical research communications

authors： Shen C,Yue H,Pei J,Guo X,Wang T,Quan JM

更新日期：2015-07-31 00:00:00

abstract：:In this study, we examined expression of tyrosylprotein sulfotransferase (TPST) isoforms TPST1 and TPST2 in primary cultures of human umbilical vein endothelial cells. For the first time coexpression of both isoforms is shown in primary human cells. Application of physiological levels of shear stress regulates express...

journal_title：Biochemical and biophysical research communications

authors： Goettsch S,Goettsch W,Morawietz H,Bayer P

更新日期：2002-06-14 00:00:00

abstract：:Purified fractions of glycosylated (pGPrl) and unglycosylated (pUGPrl) porcine prolactin were prepared by affinity chromatography on Concanavalin A-Sepharose. The relative binding activities of these two forms of prolactin for receptors from porcine mammary, adrenal cortex and rabbit mammary, as well as their Nb2 cell...

journal_title：Biochemical and biophysical research communications

authors： Atkinson PR,Seely JE,Klemcke HG,Hughes JP

更新日期：1988-09-30 00:00:00

abstract：:It is widely considered that it is not appropriate to treat beta-pairs in isolation, since other secondary structural models (such as helices, coils), protein topology and protein tertiary structures would limit beta-strand pairing. However, to understand the underlying mechanisms of beta-sheet formation, studies ough...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Ruan J,Duan G,Gao S,Zhang T

更新日期：2009-08-28 00:00:00

abstract：:External mechanical loading of cells aligns cytoskeletal stress fibres in the direction of principle strains and localises paxillin to the mechanosensing region. If the osteocyte cell body can indeed directly sense matrix strains, then cytoskeletal alignment and distribution of paxillin in osteocytes in situ will bear...

journal_title：Biochemical and biophysical research communications

authors： Vatsa A,Semeins CM,Smit TH,Klein-Nulend J

更新日期：2008-12-26 00:00:00

abstract：:Myosin light chain kinase (MLCK) is a multifunctional regulatory protein of smooth muscle contraction [IUBMB Life 51 (2001) 337, for review]. The well-established mode for its regulation is to phosphorylate the 20 kDa myosin light chain (MLC 20) to activate myosin ATPase activity. MLCK exhibits myosin-binding activity...

journal_title：Biochemical and biophysical research communications

authors： Gao Y,Kawano K,Yoshiyama S,Kawamichi H,Wang X,Nakamura A,Kohama K

更新日期：2003-05-23 00:00:00

abstract：:The ability of DNA damage to stabilize p53 in all cell cycle stages has not been examined in actively growing cells. The chemotherapeutic drug camptothecin is a topoisomerase I poison. Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind DNA. Both increase the level of p53 albeit by diff...

journal_title：Biochemical and biophysical research communications

authors： Houser S,Koshlatyi S,Lu T,Gopen T,Bargonetti J

更新日期：2001-12-21 00:00:00

abstract：:Olfactory adaptation requires the change of intracellular calcium concentration during stimuli. To contribute in the study of the molecular mechanism of calcium-dependent regulations in olfactory receptor cells, we isolated a novel 26-kDa Ca2+-binding protein named p26olf from the frog olfactory epithelium after four ...

journal_title：Biochemical and biophysical research communications

authors： Miwa N,Kobayashi M,Takamatsu K,Kawamura S

更新日期：1998-10-29 00:00:00

abstract：:The involvement of vitamin D in prostate carcinogenesis was investigated using the human prostatic LNCaP cells. Incubation of the LNCaP with 100 nM 1 alpha,25-dihydroxyvitamin D3 for 2 days resulted in a 30-40% suppression of cell growth, which was accompanied by a greater than 70% down-regulated expression of the pro...

journal_title：Biochemical and biophysical research communications

authors： Hsieh TY,Ng CY,Mallouh C,Tazaki H,Wu JM

更新日期：1996-06-05 00:00:00

abstract：:S-Adenosyl-l-methionine (SAM) is the biological methyl-group donor for the enzymatic methylation of numerous substrates including proteins. SAM has been reported to activate smooth muscle derived ryanodine receptor calcium release channels. Therefore, we examined the effects of SAM on the cardiac isoform of the ryanod...

journal_title：Biochemical and biophysical research communications

authors： Kampfer AJ,Balog EM

更新日期：2008-07-11 00:00:00

abstract：:Synthesis of melanin starts from the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (L-dopa) and then the oxidation of L-dopa yields dopaquinone by tyrosinase. Therefore, tyrosinase inhibitors have been established as important constituents of depigmentation agents. Recently, polyhydroxystilbene compounds, whi...

journal_title：Biochemical and biophysical research communications

authors： Ohguchi K,Tanaka T,Kido T,Baba K,Iinuma M,Matsumoto K,Akao Y,Nozawa Y

更新日期：2003-08-08 00:00:00

abstract：:Adiponectin, an adipocyte-derived hormone, attenuates the production of TNFalpha by activated human macrophages. In the present study, we used porcine blood-derived macrophages to test the hypothesis that the anti-inflammatory action of adiponectin includes suppression of IL6 and an induction of IL10. Adiponectin supp...

journal_title：Biochemical and biophysical research communications

authors： Wulster-Radcliffe MC,Ajuwon KM,Wang J,Christian JA,Spurlock ME

更新日期：2004-04-09 00:00:00

abstract：:Cilia/flagella are evolutionarily conserved cellular organelles. In this study, we demonstrated that Dunaliella salina Peroxiredoxin 1 (DsPrdx1) localized to the flagella and basal bodies, and was involved in flagellar disassembly. The link between DsPrdx1 and flagella of Dunaliella salina (D. salina) encouraged us to...

journal_title：Biochemical and biophysical research communications

authors： Gong F,Liu H,Li J,Xue L,Zhang M

更新日期：2014-02-14 00:00:00

abstract：:Using differential mRNA display (DD-PCR), a novel cDNA, FxC1 (Fracture Callus 1) was isolated from the early stages of a healing fractured femur. Utilizing 5' RACE PCR, a 598-bp full-length cDNA was obtained for FxC1 that contains an open reading frame (ORF) of 243 bp, encoding for an 80 amino acid protein. Within thi...

journal_title：Biochemical and biophysical research communications

authors： Hadjiargyrou M,Halsey MF,Ahrens W,Rightmire EP,McLeod KJ,Rubin CT

更新日期：1998-08-28 00:00:00

abstract：:The onset of labour is associated with an increase in prostaglandin synthesis in amnion which appears to be mediated at least in part by an increase in cyclo-oxygenase (COX) expression. We have tested the hypothesis that COX expression is controlled in amnion by the binding of a protein to the COX mRNA which may inhib...

journal_title：Biochemical and biophysical research communications

authors： Slater D,Berger L,Moore G,Bennett P

更新日期：1994-08-30 00:00:00

abstract：:microRNAs (miRNAs) play significant roles in diverse biological processes and their deregulation is implicated in carcinogenesis. miR-146a executes tumour suppressive or oncogenic functions depending on the cancer type, but its effect on human cervical (CaCx) and colorectal (CRC) cancers have not been examined thus fa...

journal_title：Biochemical and biophysical research communications

authors： Sathyanarayanan A,Chandrasekaran KS,Karunagaran D

更新日期：2016-11-25 00:00:00

abstract：:The hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an excellent example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Recently, we have identified a germline mutation of the sclerosis (Tsc2) gene in the Eker rat (Nature Geneti...

journal_title：Biochemical and biophysical research communications

authors： Orimoto K,Tsuchiya H,Kobayashi T,Matsuda T,Hino O

更新日期：1996-02-06 00:00:00

abstract：:The effect of human SCD1 heterologous expression on cellular fatty acid synthesis was investigated in the current study. The SCD1 gene expression cassette and PGK-neomycin-selectable marker cassette were co-introduced into HEK 293 cells by electroporation, and subsequently, SCD1 expression was evaluated by fatty acid ...

journal_title：Biochemical and biophysical research communications

authors： Wu Z,Li D,Gou K

更新日期：2010-07-30 00:00:00

abstract：:Protein phosphorylation plays critical roles in the regulation of protein activity and cell signaling. The level of protein phosphorylation is controlled by protein kinases and protein tyrosine phosphatases (PTPs). Disturbance of the equilibrium between protein kinase and PTP activities results in abnormal protein pho...

journal_title：Biochemical and biophysical research communications

authors： Park JE,Park BC,Song M,Park SG,Lee DH,Park SY,Kim JH,Cho S

更新日期：2009-10-02 00:00:00