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Can ENCODE tell us how much junk DNA we carry in our genome?

Abstract：

:One of the large, unsolved problems in human genetics is the proportion of functional sequences in genomes. Recently, the encyclopedia of DNA elements consortium revealed that the majority of the genome is biochemically active, which were described as biochemical functions. This has been used as evidence to pronounce the death of the junk DNA concept. In evolutionary biology, junk DNAs are sequences whose gain or loss does not seriously affect fitness of the host organism. In the human genome, a large amount of biochemical activity should be to repress the sequences so as to avoid their harmful expression. The biochemical activity is very different from functionality in the light of evolution. The single nucleotide polymorphism sites associated with disease and other phenotypes may be functional, but their abundance in the active genome regions is not reliable evidence of functionality. Because of sequence-independent functions, the proportion of functional regions would be underestimated when sequence constraints are used alone. Knockout may be the most effective means of distinguishing functional sequences from junk DNA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Niu DK,Jiang L

doi

10.1016/j.bbrc.2012.12.074

subject

Has Abstract

pub_date

2013-01-25 00:00:00

pages

1340-3

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)02422-9

journal_volume

430

pub_type

杂志文章,评审

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