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Non-lysosomal degradation pathway for N-linked glycans and dolichol-linked oligosaccharides.

Abstract：

:There is growing evidence that asparagine (N)-linked glycans play pivotal roles in protein folding and intra- or intercellular trafficking of N-glycosylated proteins. During the N-glycosylation of proteins, significant amounts of free oligosaccharides (fOSs) and phosphorylated oligosaccharides (POSs) are generated at the endoplasmic reticulum (ER) membrane by unclarified mechanisms. fOSs are also formed in the cytosol by the enzymatic deglycosylation of misfolded glycoproteins destined for proteasomal degradation. This article summarizes the current knowledge of the molecular and regulatory mechanisms underlying the formation of fOSs and POSs in mammalian cells and Saccharomyces cerevisiae.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suzuki T,Harada Y

doi

10.1016/j.bbrc.2014.05.075

subject

Has Abstract

pub_date

2014-10-17 00:00:00

pages

213-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)00947-4

journal_volume

453

pub_type

杂志文章,评审

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