当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4).

Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4).

Abstract：

:Sulfate plays an essential role in human growth and development. Here, we characterized the functional properties of the human Na(+)-sulfate cotransporter (hNaS2), determined its tissue distribution, and identified its gene (SLC13A4) structure. Expression of hNaS2 protein in Xenopus oocytes led to a Na(+)-dependent transport of sulfate that was inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate, but not by oxalate, citrate, succinate, phenol red or DIDS. Transport kinetics of hNaS2 determined a K(m) for sulfate of 0.38mM, suggestive of a high affinity sulfate transporter. Na(+) kinetics determined a Hill coefficient of n=1.6+/-0.6, suggesting a Na:SO(4)(2-) stoichiometry of 2:1. hNaS2 mRNA was highly expressed in placenta and testis, with intermediate levels in brain and lower levels found in the heart, thymus, and liver. The SLC13A4 gene contains 16 exons, spanning over 47kb in length. Its 5'-flanking region contains CAAT- and GC-box motifs, and a number of putative transcription factor binding sites, including GATA-1, AP-1, and AP-2 consensus sequences. This is the first study to characterize hNaS2 transport kinetics, define its tissue distribution, and resolve its gene (SLC13A4) structure and 5' flanking region.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Markovich D,Regeer RR,Kunzelmann K,Dawson PA

doi

10.1016/j.bbrc.2004.11.102

subject

Has Abstract

pub_date

2005-01-28 00:00:00

pages

729-34

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02691-9

journal_volume

326

pub_type

杂志文章

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