Involvement of the osmosensor histidine kinase and osmotic stress-activated protein kinases in the regulation of secondary metabolism in Fusarium graminearum.

abstract：:KK mice are genetically diabetic animals, showing glucose intolerance and insulin resistance. We examined the effects of 3,3',5-triiodo-L-thyronine (T3) on the blood glucose level and on mRNA levels of muscle cell differentiation markers in hyperglycemic KK mice. T3 treatment (T1, 1 mg; T3, 3 mg; T10, 10 mg/kg/day) of...

journal_title：Biochemical and biophysical research communications

authors： Shimokawa T,Kato M,Shioduka K,Irie J,Ezaki O

更新日期：1997-06-27 00:00:00

abstract：:ATP cassette binding protein 1 (ABCA1) controls the apolipoprotein-mediated cholesterol efflux pathway and determines plasma HDL levels. Although cAMP is known to promote ABCA1 expression and cholesterol efflux from cells, it has not been determined whether cyclic nucleotide phosphodiesterase (PDE) isoforms regulate t...

journal_title：Biochemical and biophysical research communications

authors： Lin G,Bornfeldt KE

更新日期：2002-01-18 00:00:00

abstract：:In the rat, pancreatic HCO(-)(3) secretion is believed to be mediated by duct cells with an apical Cl(-)/HCO(-)(3) exchanger acting in parallel with a cAMP-activated Cl(-) channel and protons being extruded through a basolateral Na(+)/H(+) exchanger. However, this may not be the only mechanism for HCO(-)(3) secretion ...

journal_title：Biochemical and biophysical research communications

authors： Thévenod F,Roussa E,Schmitt BM,Romero MF

更新日期：1999-10-14 00:00:00

abstract：:Cancer cell adhesion to vascular endothelium is a critical process in hematogenous metastasis. We hypothesized that breast cancer cells express ligands that bind under blood flow conditions to E-selectin expressed by endothelial cells. At a hemodynamic wall shear rate, BT-20 and MDA-MB-468 breast cancer cells adhered ...

journal_title：Biochemical and biophysical research communications

authors： Shirure VS,Henson KA,Schnaar RL,Nimrichter L,Burdick MM

更新日期：2011-03-18 00:00:00

abstract：:Enhancer of Zeste 2 (EZH2) is the key enzymatic factor in Polycomb Repressive Complex 2 (PRC2), a transcriptional repressor which contributes to oncogenesis. Recent research has revealed the key role of aberrant EZH2 hyper-activity in human gliomas. Here, we examined the role of the lesser-known PRC2-associated PHD Fi...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Ji H,Tang H,Xu Z

更新日期：2018-09-10 00:00:00

abstract：:Human monomorphic and polymorphic arylamine acetyltransferases (EC 2.3.1.5) were expressed in monkey kidney COS-1 cells and used to study the N- and O-acetylation of a number of carcinogenic amines and their N-hydroxy metabolites. The monomorphic enzyme N-acetylated the aromatic amines, 2-aminofluorene and 4-aminobiph...

journal_title：Biochemical and biophysical research communications

authors： Minchin RF,Reeves PT,Teitel CH,McManus ME,Mojarrabi B,Ilett KF,Kadlubar FF

更新日期：1992-06-30 00:00:00

abstract：:Assay systems for the evaluation of carcinogen interaction with human tissues are essential for assessing cancer risk. Human hair roots (HHR) are a readily obtainable epithelial tissue source that have been employed for investigating inherited enzyme activities. In this study HHR were found to possess cytochrome P-450...

journal_title：Biochemical and biophysical research communications

authors： Merk HF,Mukhtar H,Schutte B,Kaufmann I,Das M,Bickers DR

更新日期：1987-10-29 00:00:00

abstract：:Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregul...

journal_title：Biochemical and biophysical research communications

authors： Agostini M,Tucci P,Melino G

更新日期：2011-10-28 00:00:00

abstract：:Endothelin-like immunoreactivity (-LI) was detected in the kidney, spleen, skeletal muscle, lung and in plasma of the pig. The highest tissue levels were found in the lung (1.5 +/- 0.07 pmol/g) and the lowest in the muscle (0.08 +/- 0.02 pmol/g). I.v. infusion of endothelin (20 pmol/kg/min for 20 min) increased plasma...

journal_title：Biochemical and biophysical research communications

authors： Pernow J,Hemsén A,Lundberg JM

更新日期：1989-06-15 00:00:00

abstract：:The immunosuppressant FK506 inhibits thymocyte positive selection. Calcineurin, a FK506-sensitive Ca2+/calmodulin-dependent protein phosphatase, is presumed to be involved in this event without direct evidence. We have previously shown that moderate stimulation of CD4(+)CD8(+) thymocytes with a combination of the calc...

journal_title：Biochemical and biophysical research communications

authors： Kuwata T,Asada A,Ohoka Y,Mukai M,Miyaike M,Iwata M

更新日期：1998-06-18 00:00:00

abstract：:Ca2+ channels are involved in the regulation of vascular functions. Angiotensin II is implicated in the development of atherosclerosis and vascular remodeling. In this study, we demonstrated that angiotensin II preferentially increased the expression of alpha1G, a T-type Ca2+ channel subunit, via AT1 receptors in endo...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Hirase T,Inoue T,Node K

更新日期：2006-08-25 00:00:00

abstract：:A series of C-terminal deleted analogs of human growth hormone-releasing factor (hGRF) with either an amidated or a free carboxylic acid C-terminus were synthesized by solid phase methodology. Their capacity to release growth hormone was tested on rat anterior pituitary cells in monolayer culture. A gradual decrease o...

journal_title：Biochemical and biophysical research communications

authors： Ling N,Baird A,Wehrenberg WB,Ueno N,Munegumi T,Brazeau P

更新日期：1984-09-17 00:00:00

abstract：:Adult stem cells provide a promising alternative for the treatment of decompensated liver cirrhosis. Our previous study showed that peripheral blood monocytes (PBMCs) from decompensated liver cirrhosis could differentiate into hepatocyte-like cells in vitro. We here aimed to investigate the differential potential of t...

journal_title：Biochemical and biophysical research communications

authors： Yan L,Han Y,Wang J,Liu J,He Y,Wang H,Fan D

更新日期：2008-07-11 00:00:00

abstract：:Alzheimer's disease is a growing concern in the context of the increasing lifespan of the populations. The work presented here is part of the fight against this threat. It supports a therapeutic approach to reduce the incidence of Alzheimer's disease, taking advantage of the specific binding of several domains of Netr...

journal_title：Biochemical and biophysical research communications

authors： Borel F,Marzocca F,Delcros JG,Rama N,Mehlen P,Ferrer JL

更新日期：2017-07-01 00:00:00

abstract：:Platelet-derived growth factor-D (PDGF-D) is a more recent recognized growth factor involved in the regulation of several cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by binding to and activating its cognate receptor PDGFR-β. After bile duct ligation or in the carbon tet...

journal_title：Biochemical and biophysical research communications

authors： Borkham-Kamphorst E,Alexi P,Tihaa L,Haas U,Weiskirchen R

更新日期：2015-02-13 00:00:00

abstract：:A fast kinetics, spectroscopic technique has been applied to the study of the transient cation flux associated to the binding of cholinergic agonist to native acetylcholine receptor (AcChR)-rich membrane vesicles in presence of anti-AcChR antibodies. The technique is based on the collisional quenching of an intravesic...

journal_title：Biochemical and biophysical research communications

authors： Gonzalez-Ros JM,Ferragut JA,Martinez-Carrion M

更新日期：1984-04-30 00:00:00

abstract：:Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally exp...

journal_title：Biochemical and biophysical research communications

authors： Huang SJ,Yang WS,Lin YW,Wang HC,Chen CC

更新日期：2008-07-11 00:00:00

abstract：:Pretreatment of brain synaptic membrane homogenates with Triton X-100 resulted in a drastic disclosure of [3H] glutamate (Glu) binding activity which was sensitive to one of the central Glu receptor agonists, N-methyl-D-aspartic acid (NMDA). The NMDA-sensitive binding was inversely dependent on the incubation temperat...

journal_title：Biochemical and biophysical research communications

authors： Ogita K,Yoneda Y

更新日期：1988-06-16 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of cardiovascular diseases and are modified in response to a variety of stimuli such as bioactive peptides, cytokines and/or grown factors. In this study, we demonstrated that angiotensin II (Ang II) induces a time- and dose-dependent increase...

journal_title：Biochemical and biophysical research communications

authors： Jiménez E,Pérez de la Blanca E,Urso L,González I,Salas J,Montiel M

更新日期：2009-03-20 00:00:00

abstract：:A new cleavage site, which is a post-translational modification, was found between residues His-154 and Ala-155 in alpha A-crystallin from the aged human lens. After trypsin digestion of alpha A-crystallin two peptides that include Asp-151 were obtained and have remarkable differences. That is, the stereo-configuratio...

journal_title：Biochemical and biophysical research communications

authors： Fujii N,Momose Y,Yamasaki M,Yamagaki T,Nakanishi H,Uemura T,Takita M,Ishii N

更新日期：1997-10-29 00:00:00

abstract：:Yeast Ccc2 is a P-type ATPase responsible for transport of copper(I) from the cytosol to the trans-Golgi network. It possesses a soluble cytosolic N-terminal region containing two copper(I)-binding domains. Homologous eukaryotic copper-transporting ATPases have from one to six domains. We have expressed a fragment enc...

journal_title：Biochemical and biophysical research communications

authors： Banci L,Bertini I,Chasapis CT,Rosato A,Tenori L

更新日期：2007-12-21 00:00:00

abstract：:Diaminopimelate (DAP) epimerase catalyzes the stereoinversion of ll-DAP to meso-DAP, a precursor of l-lysine and an essential component of the bacterial peptidoglycan. This function is vital to bacteria and the enzyme therefore represents an attractive target for the design of novel anti-bacterials. DAP epimerase belo...

journal_title：Biochemical and biophysical research communications

authors： Pillai B,Cherney M,Diaper CM,Sutherland A,Blanchard JS,Vederas JC,James MN

更新日期：2007-11-23 00:00:00

abstract：:Fut8 (α1,6-Fucosyltransferase) heterozygous knock-out (Fut8(+/-)) mice had an increased influx of inflammatory cells into the lungs, and this was associated with an up-regulation of matrix metalloproteinases, MMP-2 and MMP-9, after treatment with porcine pancreatic elastase (PPE), exhibiting an emphysema-prone phenoty...

journal_title：Biochemical and biophysical research communications

authors： Kamio K,Yoshida T,Gao C,Ishii T,Ota F,Motegi T,Kobayashi S,Fujinawa R,Ohtsubo K,Kitazume S,Angata T,Azuma A,Gemma A,Nishimura M,Betsuyaku T,Kida K,Taniguchi N

更新日期：2012-07-20 00:00:00

abstract：:Severe cold exposure and pressure overload are both known to prompt oxidative stress and pathological alterations in the heart although the interplay between the two remains elusive. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and en...

journal_title：Biochemical and biophysical research communications

authors： Lu S,Xu D

更新日期：2013-12-06 00:00:00

abstract：:Total RNA isolated from a rainbow trout (Oncorhynchus mykiss) liver was subjected to RT/PCR using degenerate primers designed from homologous regions amongst cytochrome P450 CYP4 proteins. PCR amplification resulted in a single electrophoretic band which was excised, purified and sequenced directly, using cycle sequen...

journal_title：Biochemical and biophysical research communications

authors： Falckh PH,Wu QK,Ahokas JP

更新日期：1997-07-18 00:00:00

abstract：:MicroRNAs (miRNAs) that negatively regulate gene expression have emerged as novel therapeutic tools for cancer treatment. In this study, we investigated the potential role of Liver receptor homolog-1 (LRH-1), a novel oncogene, in non-small-cell lung cancer (NSCLC), and examined the regulation of LRH-1 by miRNAs. We fo...

journal_title：Biochemical and biophysical research communications

authors： Jiang W,Tian Y,Jiang S,Liu S,Zhao X,Tian D

更新日期：2016-05-13 00:00:00

abstract：:Wet elastoidin spicules (fish fin rays) yield low-angle meridional X-ray diffraction patterns which resemble those from tendons. However, when the spicule dries the meridian splits into the arms of a diagonal cross (sometimes only one arm appears). Of the possible explanations we reject shearing of the axial arrangeme...

journal_title：Biochemical and biophysical research communications

authors： Hukins DW,Woodhead-Galloway J,Knight DP

更新日期：1976-12-20 00:00:00

abstract：:Cofilin, a key regulator of actin filament dynamics, binds to G- and F-actin and promotes actin filament turnover by stimulating depolymerization and severance of actin filaments. In this study, cytochalasin D (CytoD), a widely used inhibitor of actin dynamics, was found to act as an inhibitor of the G-actin-cofilin i...

journal_title：Biochemical and biophysical research communications

authors： Shoji K,Ohashi K,Sampei K,Oikawa M,Mizuno K

更新日期：2012-07-20 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic, and accounts for more than 15% of strokes. Mutations in cardiac sodium channel alpha, beta1 and beta2 subunit genes (SCN5A, SCN1B, and SCN2B) have been identified in AF patients. We hypothesize that mutations in the sodium channel beta3 subu...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Yang Q,Wu X,Yang Y,Shi L,Wang C,Wu G,Xia Y,Yang B,Zhang R,Xu C,Cheng X,Li S,Zhao Y,Fu F,Liao Y,Fang F,Chen Q,Tu X,Wang QK

更新日期：2010-07-16 00:00:00

abstract：:Coronary collateral circulation (CCC) functions as a natural bypass in the event of coronary obstruction, which markedly improves prognosis in patients with coronary artery disease (CAD). MicroRNAs (miRNAs) have been implicated in multiple physiological and pathological processes, including angiogenesis involved in CC...

journal_title：Biochemical and biophysical research communications

authors： Hou S,Fang M,Zhu Q,Liu Y,Liu L,Li X

更新日期：2017-02-26 00:00:00