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Biochemical properties associated with the immortalizing domain of the large T protein of polyoma virus.

Abstract：

:A fragment of polyoma virus DNA lacking the carboxy-terminal part of the large T antigen coding region is sufficient to express the functions of the entire gene in cell transformation. Two cell lines expressing this truncated DNA were studied, one of them producing a large T-related protein of the expected size (37 kDa) and the other one, a shorter product (34 kDa). Both proteins were phosphorylated and localized in the nucleus, but devoid of ATPase and nucleotide binding activities. As the complete protein, the larger product, but not the shorter variant, exhibited sequence-specific DNA binding properties. These results indicate that ATPase and nucleotide-binding activities are not required for immortalization, and suggest that recognition of specific DNA sequences may be dispensable.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Guizani I,Clertant P,Cuzin F

doi

10.1016/s0006-291x(87)80059-1

subject

Has Abstract

pub_date

1987-04-29 00:00:00

pages

973-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(87)80059-1

journal_volume

144

pub_type

杂志文章

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