Human autoantibodies against a nucleolar protein.

abstract：:Several genes are significantly mutated in breast cancer but only a small percentage of mutations are well-known to contribute to cancer development. FASN is involved in de novo lipogenesis and the regulation of ERα signaling. However, the effect of genetic mutations affecting FASN in breast cancer has not thoroughly ...

journal_title：Biochemical and biophysical research communications

authors： Gonzalez-Salinas F,Rojo R,Martinez-Amador C,Herrera-Gamboa J,Trevino V

更新日期：2020-08-20 00:00:00

abstract：:Bovine erythrocyte green heme binding protein and bovine erythrocyte flavin reductase have been isolated in highly purified forms and subjected to amino acid analysis and N-terminal amino acid sequence analysis. The two proteins possess similar amino acid compositions and identical N-terminal amino acid sequences. Mor...

journal_title：Biochemical and biophysical research communications

authors： Quandt KS,Xu F,Chen P,Hultquist DE

更新日期：1991-07-15 00:00:00

abstract：:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypo...

journal_title：Biochemical and biophysical research communications

authors： Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda T

更新日期：1986-01-14 00:00:00

abstract：:Phyllanthus niruri is used in herbal medicine for treatment of diabetes. The objective of this study was to investigate the antidiabetic potential of P. niruri, using assays for α-glucosidase, muscle glucose transport, liver glucose production and adipogenesis. α-Glucosidase inhibitory activity was performed on aqueou...

journal_title：Biochemical and biophysical research communications

authors： Najari Beidokhti M,Andersen MV,Eid HM,Sanchez Villavicencio ML,Staerk D,Haddad PS,Jäger AK

更新日期：2017-11-04 00:00:00

abstract：:We found that both RNA and cDNA preparations derived from melanocytes contain a RT-PCR inhibitor that copurified with nucleic acids. Investigation of the candidate inhibitor melanin revealed that it potently blocks PCR at concentrations below 200 ng/ml, whereas 100 microg/ml melanin was required to inhibit reverse tra...

journal_title：Biochemical and biophysical research communications

authors： Eckhart L,Bach J,Ban J,Tschachler E

更新日期：2000-05-19 00:00:00

abstract：BACKGROUND:Platelet microparticles (PMPs) are closely associated with diabetic macrovascular complications. This study aimed to explore the underlying mechanisms of high glucose-induced PMPs generation. METHODS:Washed platelets, obtained from the plasma of healthy male Sprague-Dawley rats, were incubated with high glu...

journal_title：Biochemical and biophysical research communications

authors： Wang GH,Ma KL,Zhang Y,Hu ZB,Liu L,Lu J,Chen PP,Lu CC,Ruan XZ,Liu BC

更新日期：2019-02-05 00:00:00

abstract：:Apoptosis is a mode of cell death characterized by chromatin condensation and disassembly of the nuclear lamina, processes that are also characteristic of mitosis. The apparent similarity between the two events, together with observations that apoptosis can occur following G2 arrest, has led to the suggestion that apo...

journal_title：Biochemical and biophysical research communications

authors： Norbury C,MacFarlane M,Fearnhead H,Cohen GM

更新日期：1994-08-15 00:00:00

abstract：:We previously reported that 5-methoxyindole-2-carboxylic acid (MICA) could induce preconditioning effect in the ischemic brain of rat. In the present study, we addressed the question of whether MICA could also trigger a postconditioning effect in ischemic stroke. To this end, MICA (100 mg/kg body weight) was injected ...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Jin Z,Yang X,Yan LJ

更新日期：2018-02-26 00:00:00

abstract：:Lysophosphatidyl-L-serine (lysoPS) is thought to be an immunological regulator because it dramatically augments the degranulation of rat peritoneal mast cells (RPMCs). This stimulatory effect may be mediated by a lysoPS receptor, but its molecule has not been identified yet. During a ligand fishing study for the orpha...

journal_title：Biochemical and biophysical research communications

authors： Sugo T,Tachimoto H,Chikatsu T,Murakami Y,Kikukawa Y,Sato S,Kikuchi K,Nagi T,Harada M,Ogi K,Ebisawa M,Mori M

更新日期：2006-03-24 00:00:00

abstract：:Myocardium of mammals contains a wide range of isoforms of proteins that provides contractile function of the heart. These are two isoforms of ventricular and two of atrial myosin, α- and β-tropomyosin, and two isoforms of α-actin: cardiac and skeletal. We believe that the difference in the amino acid sequence of α-ac...

journal_title：Biochemical and biophysical research communications

authors： Shchepkin DV,Nikitina LV,Bershitsky SY,Kopylova GV

更新日期：2017-08-19 00:00:00

abstract：:Recent progress in the field of mesenchymal stem cell (MSC) biology has enabled their clinical application. In the autologous cell transplantation therapy, the source of MSCs are quite important to reduce patients' physical burden. In this study, we isolated MSCs from the synovial fluid (SF) and synovial membrane (Syn...

journal_title：Biochemical and biophysical research communications

authors： Amemiya M,Tsuji K,Katagiri H,Miyatake K,Nakagawa Y,Sekiya I,Muneta T,Koga H

更新日期：2020-03-05 00:00:00

abstract：:Dexamethasone (DEX), a glucocorticoid which induces cleft palate, causes marked alterations in the synthesis and degradation of phosphatidylinositol (PI) but not phosphatidylcholine in an established fibroblastic cell line derived from a human embryonic palate. Incorporation of radiolabeled inositol into phosphatidyli...

journal_title：Biochemical and biophysical research communications

authors： Grove RI,Willis WD,Pratt RM

更新日期：1983-01-14 00:00:00

abstract：:E-selectin has a "multi-recognition" capability in terms of epitope binding specificity, depending on adhesion conditions (static vs. low- or high-shear stress dynamic systems). Specifically, (i) adhesion based on expression of alpha 2-->3 sialylated Le(x) (SLe(x)) is prominent under static or low shear stress dynamic...

journal_title：Biochemical and biophysical research communications

authors： Kojima N,Handa K,Newman W,Hakomori S

更新日期：1992-12-30 00:00:00

abstract：:Studies have shown that High mobility group A2 (HMGA2), a non-histone protein, can promote epithelial-mesenchymal transition (EMT), which plays a critical role in prostate cancer progression and metastasis. Interestingly, full-length or wild-type HMGA2 and truncated (lacking the 3'UTR) HMGA2 isoforms are overexpressed...

journal_title：Biochemical and biophysical research communications

authors： Hawsawi O,Henderson V,Burton LJ,Dougan J,Nagappan P,Odero-Marah V

更新日期：2018-09-26 00:00:00

abstract：:On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supple...

journal_title：Biochemical and biophysical research communications

authors： Koch OR,De Leo ME,Borrello S,Palombini G,Galeotti T

更新日期：1994-06-30 00:00:00

abstract：:We demonstrated lanthionine introduction into hexa-histidine-tagged (His-tagged) nukacin ISK-1 prepeptide NukA by modification enzyme NukM in Escherichia coli. Co-expression of nukA and nukM, purification of the resulting His-tagged prepeptide by affinity chromatography, and subsequent mass spectrometry analysis showe...

journal_title：Biochemical and biophysical research communications

authors： Nagao J,Harada Y,Shioya K,Aso Y,Zendo T,Nakayama J,Sonomoto K

更新日期：2005-10-21 00:00:00

abstract：:Allylisothiocyanate (ANCS) is shown to inhibit (H+ + K+)-ATPase isolated from the parietal cell of hog gastric mucosa. The ATPase is the proton pump in the secretory membrane of the parietal cell and is an essential component of the acid secretory mechanism. Furthermore, ANCS suppresses acid secretion by bullfrog gast...

journal_title：Biochemical and biophysical research communications

authors： Takeguchi N,Nishimura Y,Watanabe T,Mori Y,Morii M

更新日期：1983-04-29 00:00:00

abstract：:Different groups including ours have shown that curcumin induces melanoma cell apoptosis, here we focused the role of mammalian Sterile 20-like kinase 1 (MST1) in it. We observed that curcumin activated MST1-dependent apoptosis in cultured melanoma cells. MST1 silencing by RNA interference (RNAi) suppressed curcumin-i...

journal_title：Biochemical and biophysical research communications

authors： Yu T,Ji J,Guo YL

更新日期：2013-11-08 00:00:00

abstract：:Endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are important lipid mediators for immunosuppressive effects and for appropriate homeostasis via their G-protein-coupled cannabinoid (CB) receptors in mammalian organs and tissues, and may be involved in wound healing in some organs. The phys...

journal_title：Biochemical and biophysical research communications

authors： Kozono S,Matsuyama T,Biwasa KK,Kawahara K,Nakajima Y,Yoshimoto T,Yonamine Y,Kadomatsu H,Tancharoen S,Hashiguchi T,Noguchi K,Maruyama I

更新日期：2010-04-16 00:00:00

abstract：:Chondrocyte- or chondrosarcoma cell line (HCS)-specific DNA fragments were obtained using differential display-PCR. Nucleotide sequences of 32 species derived from HCS cells were determined. One of the sequence tags (tag no. 24) corresponded to the nucleotide sequence of connective tissue growth factor (CTGF). Norther...

journal_title：Biochemical and biophysical research communications

authors： Nakanishi T,Kimura Y,Tamura T,Ichikawa H,Yamaai Y,Sugimoto T,Takigawa M

更新日期：1997-05-08 00:00:00

abstract：:Lembehyne A (LB-A), a spongean polyacetylene, induced neuronal cell differentiation in a neuroblastoma cell line, Neuro 2A. The LB-A treatment of Neuro 2A cells predominantly resulted in a morphological change with bipolar neurites. The acetylcholinesterase activity of Neuro 2A was also increased by the treatment of L...

journal_title：Biochemical and biophysical research communications

authors： Aoki S,Matsui K,Takata T,Hong W,Kobayashi M

更新日期：2001-11-30 00:00:00

abstract：:Store-operated Ca(2+) entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using ...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Shiota M,Ohkawa Y,Baba A,Wanibuchi H,Kinashi T,Kurosaki T,Baba Y

更新日期：2012-06-15 00:00:00

abstract：:We have previously shown that DNA elements controlling tissue specific expression of the rat thyroglobulin gene extend 170 bp upstream of the cap site and have identified a thyroid specific nuclear factor which binds the promoter in the -60 region (site C). Here we report that the distal portion of the promoter, exten...

journal_title：Biochemical and biophysical research communications

authors： Ursini MV,Gallo A,Olivetta E,Musti AM

更新日期：1989-08-30 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia (CML) is a type of cancer that starts in certain blood-forming cells of the bone marrow. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well known protooncogene, has be shown to be upregulated in various tumor types, including multiple myeloma. However, the...

journal_title：Biochemical and biophysical research communications

authors： Wen F,Cao YX,Luo ZY,Liao P,Lu ZW

更新日期：2018-12-09 00:00:00

abstract：:Heavy water (D2O) has been used as a putative inhibitor of the plasma membrane H(+)-ATPase and the plasma membrane redox system. Concentrations above 50% D2O inhibited H+ secretion and the plasma membrane redox system of Zea mays L. roots. Inhibition of H+ secretion by vanadate was reduced in presence of D2O. The plas...

journal_title：Biochemical and biophysical research communications

authors： Döring O,Böttger M

更新日期：1992-01-31 00:00:00

abstract：:Nek2 is a mammalian protein kinase that is structurally homologous to NIMA, a mitotic regulator in Aspergillus nidulans. To understand the possible cellular processes in which Nek2 participates during the cell cycle, we investigated the expression and subcellular localization of Nek2 in mitotic cells. The Nek2 protein...

journal_title：Biochemical and biophysical research communications

authors： Ha Kim Y,Yeol Choi J,Jeong Y,Wolgemuth DJ,Rhee K

更新日期：2002-01-18 00:00:00

abstract：:Ghrelin is a peptide found in the hypothalamus and stomach that stimulates food intake and whose circulating concentrations are affected by nutritional state. Very little is known about other central behavioral effects of ghrelin, and thus, we investigated the effects of ghrelin on anxiety and memory retention. The pe...

journal_title：Biochemical and biophysical research communications

authors： Carlini VP,Monzón ME,Varas MM,Cragnolini AB,Schiöth HB,Scimonelli TN,de Barioglio SR

更新日期：2002-12-20 00:00:00

abstract：:The ubiquitin-proteasome pathway is an important regulatory system for the lifetime of inducible nitric-oxide synthase (iNOS), a high-output isoform compared to neuronal NOS (nNOS) and endothelial NOS (eNOS), to prevent overproduction of NO that could trigger detrimental effects such as cytotoxicity. Two E3 ubiquitin ...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Nishiya T,Maekawa S,Horinouchi T,Ogasawara K,Uehara T,Miwa S

更新日期：2011-05-27 00:00:00

abstract：:Astrocyte elevated gene-1 (AEG-1), upregulated in various types of malignancies including colorectal cancer (CRC), has been reported to be associated with the carcinogenesis. MicroRNAs (miRNAs) are widely involved in the initiation and progression of cancer. However, the functional significance of AEG-1 and the relati...

journal_title：Biochemical and biophysical research communications

authors： Huang S,Wu B,Li D,Zhou W,Deng G,Zhang K,Li Y

更新日期：2014-02-14 00:00:00

abstract：:Transforming growth factor alpha (TGF alpha) induces dose- and time-dependent stimulation of prostacyclin (PGI2) production by cultured human umbilical vein endothelial cells. The lowest stimulatory concentration of TGF alpha was 0.1 ng/ml and the maximal response, a 2.7-fold rise, was obtained with 10 ng/ml. The stim...

journal_title：Biochemical and biophysical research communications

authors： Ristimäki A

更新日期：1989-05-15 00:00:00