Abstract:
:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypothyroid rats than in euthyroid rats. ANP content and concentration in the atria were lower (p less than 0.01) in hyperthyroid rats than in hypothyroid rats. An inverse correlation was found between the plasma ANP and ANP concentration in the atria (n = 15, r = 0.60, p less than 0.01). The results indicate an increased systemic release of ANP from the atria in hyperthyroidism and a decreased systemic release in hypothyroidism.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda Tdoi
10.1016/0006-291x(86)90544-9subject
Has Abstractpub_date
1986-01-14 00:00:00pages
178-83issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(86)90544-9journal_volume
134pub_type
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