Atrial natriuretic polypeptide in atria and plasma in experimental hyperthyroidism and hypothyroidism.

Abstract:

:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypothyroid rats than in euthyroid rats. ANP content and concentration in the atria were lower (p less than 0.01) in hyperthyroid rats than in hypothyroid rats. An inverse correlation was found between the plasma ANP and ANP concentration in the atria (n = 15, r = 0.60, p less than 0.01). The results indicate an increased systemic release of ANP from the atria in hyperthyroidism and a decreased systemic release in hypothyroidism.

authors

Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda T

doi

10.1016/0006-291x(86)90544-9

subject

Has Abstract

pub_date

1986-01-14 00:00:00

pages

178-83

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)90544-9

journal_volume

134

pub_type

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