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Dexamethasone affects phosphatidylinositol synthesis and degradation in cultured human embryonic cells.

Abstract：

:Dexamethasone (DEX), a glucocorticoid which induces cleft palate, causes marked alterations in the synthesis and degradation of phosphatidylinositol (PI) but not phosphatidylcholine in an established fibroblastic cell line derived from a human embryonic palate. Incorporation of radiolabeled inositol into phosphatidylinositol as well as degradation of prelabeled phosphatidylinositol is stimulated by DEX. The dose-response curves for the DEX-induced effect on PI synthesis and DEX-induced inhibition of cell proliferation are nearly identical, with the maximal responses occurring at 10(-8)M DEX. Our results suggest that DEX-induced inhibition of human embryonic palatal mesenchyme cell proliferation and alterations in synthesis and degradation of phosphatidylinositol are related.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Grove RI,Willis WD,Pratt RM

doi

10.1016/0006-291x(83)91280-9

subject

Has Abstract

pub_date

1983-01-14 00:00:00

pages

200-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91280-9

journal_volume

110

pub_type

杂志文章

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