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Physiological role of the association complexes of alpha-crystallin and its substrates on the chaperone activity.

Abstract：

:Previous reports on the chaperone activity of alpha-crystallin to prevent protein denaturation and thermal aggregation have suggested that partially denatured proteins can bind alpha-crystallin in its central region. Likewise, beta- and gamma-crystallin can also be localized to the central cavity of alpha-crystallin particle in vivo, which provides indirect evidence that alpha-crystallin can function as a chaperone in the intact lens. In this study, we have further demonstrated that the binding of the substrate proteins to alpha-crystallin by short-term preincubation may mimic the in vivo conditions of crystallin association. Preheating of alpha-crystallin with its substrate proteins at 60 degrees C for 20 min resulted in the formation of stable complexes between alpha-crystallin and its substrates (8.0% of insulin or 5.3% of gamma-crystallin was involved in complex formation). Under such conditions, the chaperone activity of alpha-crystallin to inhibit dithiothreitol-, ultraviolet-, or oxidation-induced protein aggregation can be greatly enhanced. Since UV-irradiation and oxidative stress are common insults to eye lenses under normal physiological conditions, the presence of alpha/gamma and alpha/beta complex in vivo may play an important role to maintain the lens in a transparent state.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lee JS,Samejima T,Liao JH,Wu SH,Chiou SH

doi

10.1006/bbrc.1998.8272

subject

Has Abstract

pub_date

1998-03-17 00:00:00

pages

379-83

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98272-9

journal_volume

244

pub_type

杂志文章

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