当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Monocarboxylate transporters in breast cancer and adipose tissue are novel biomarkers and potential therapeutic targets.

Monocarboxylate transporters in breast cancer and adipose tissue are novel biomarkers and potential therapeutic targets.

Abstract：

:Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate metabolism and associated with poor prognosis in solid tumours including breast cancer (BC). This study aimed to evaluate the clinical and prognostic value of MCTs used by immunohistochemistry and quantum dots-based fluorescent imaging technique in BC and surrounding stroma with emphasis on the interaction between tumour and stroma. Moreover, the data from The Cancer Genome Atlas (TCGA) was analyzed to evaluate the association between MCTs mRNA expression and prognosis of breast cancer patients. Our study found that MCT1 overexpression was observed in hormone receptor-negative and high-proliferation subtypes. High expression of MCT1 and MCT4 in tumour tissues was associated with poor patient outcome; further the correlation between MCT1 expression and poor prognosis in breast cancer was further strengthened when combined with MCT4 overexpression in the adjacent adipose tissue. These results demonstrate that MCTs tend to play a role in the aggressive BC subtypes through the dynamic interaction between breast cancer cells and adipocytes, and developing therapeutics to block this interaction will be a promising strategy in cancer therapy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Li Z,Wu Q,Sun S,Wu J,Li J,Zhang Y,Wang C,Yuan J,Sun S

doi

10.1016/j.bbrc.2018.05.091

subject

Has Abstract

pub_date

2018-07-02 00:00:00

pages

962-967

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)31154-9

journal_volume

501

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1.

    abstract：:In this study, the effects of acetylsalicylic acid (aspirin) on the expression of uPAR and the mechanism by which it regulates expression of uPAR was examined in two different colon cancer cell lines HCT116 and GEO, respectively. The study shows that under physiological concentration, aspirin upregulates steady-state ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.07.098

    authors： Jamaluddin MS

    更新日期：2006-09-22 00:00:00

  • SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.

    abstract：:Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation and its precise biological function is poorly understood. During our studies on heat-shock responses, we found...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.025

    authors： Kim HJ,Yun J,Lee J,Hong H,Jeong J,Kim E,Bae YS,Lee KJ

    更新日期：2011-07-08 00:00:00

  • Delivery of anti-GAP-43 antibodies into neuroblastoma cells reduces growth cone size.

    abstract：:We have previously demonstrated that antibodies to the growth-associated protein, GAP-43, introduced intracellularly using a lipid carrier inhibited neurite outgrowth in NB2a/d1 neuroblastoma cells, and that culturing of these cells on adhesive substrates such as laminin or poly-L-lysine overcame this restriction. The...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2204

    authors： Shea TB

    更新日期：1994-08-30 00:00:00

  • The APC regulator CDH1 is essential for the progression of embryonic cell cycles in Xenopus.

    abstract：:The orderly progression of cell cycle depends on timely destruction of key regulators through ubiquitin-mediated proteolysis. The anaphase-promoting complex (APC) is a major component of this degradation machinery and its activation is regulated by CDC20 and CDH1. We demonstrate here that CDH1 mRNA is ubiquitously exp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00447-3

    authors： Zhou Y,Ching YP,Ng RW,Jin DY

    更新日期：2002-05-31 00:00:00

  • Characterization of casein kinase II in human colonic carcinomas after heterotransplantation into nude mice.

    abstract：:Casein kinase II (CKII) activity in colorectal tumours was compared before and after heterotransplantation onto nude mice. The test revealed that the enzyme activity was about two-fold enhanced in the tumours isolated from the nude mice when compared to the respective primary tumours from which they were derived. Immu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92184-0

    authors： Seitz G,Münstermann U,Schneider HR,Issinger OG

    更新日期：1989-08-30 00:00:00

  • In vivo detection of a three iron cluster in fumarate reductase from Escherichia coli.

    abstract：:Escherichia coli with plasmid amplified expression of fumarate reductase was grown anaerobically on a medium containing fumarate and glycerol and investigated by electron paramagnetic resonance spectroscopy. Anaerobically harvested cells exhibit an EPR signal characteristic of a reduced [2Fe-2S] cluster. Anaerobic add...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91287-2

    authors： Johnson MK,Morningstar JE,Cecchini G,Ackrell BA

    更新日期：1985-09-16 00:00:00

  • Interaction of DNA hairpin loops and a complementary strand by a triplet of base pairs.

    abstract：:Hypothesis of non-enzymatic recognition of primordial tRNA and mRNA precursors is experimentally approached. DNA hairpins containing a different number of deoxyguanosine residues in the loop are analyzed for their binding ability to a chemically fixed single-strand of oligo(dC). In presence of small Mg2+ concentration...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80971-9

    authors： Baumann U,Frank R,Blöcker H

    更新日期：1988-12-30 00:00:00

  • Rundown of GH3 cell K+ conductance response to TRH following patch recording can be obviated with GH3 cell extract.

    abstract：:GH3/B6 pituitary cells release prolactin (PRL) in response to thyrotropin releasing hormone (TRH). Electrophysiological assays of individual GH3 cells with sharp high-resistance microelectrodes have revealed complex effects of TRH on membrane excitability consisting of a transient hyperpolarization (1), which is thoug...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91222-2

    authors： Dufy B,MacDermott A,Barker JL

    更新日期：1986-05-29 00:00:00

  • Physical activity in the androgen receptor knockout mouse: evidence for reversal of androgen deficiency on cancellous bone.

    abstract：:Disruption of the androgen receptor (AR) in male mice reduces cortical bone expansion and muscle mass during puberty and results in high bone turnover-related cancellous osteopenia. We hypothesized that voluntary wheel running during growth is able to rescue the effects of AR disruption on bone. To this end, 5-week-ol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.11.016

    authors： Ophoff J,Callewaert F,Venken K,De Gendt K,Ohlsson C,Gayan-Ramirez G,Decramer M,Boonen S,Bouillon R,Verhoeven G,Vanderschueren D

    更新日期：2009-01-02 00:00:00

  • Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts.

    abstract：:Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac fibrosis, a diffuse and disproportionate accumulation of collagen in the myocardium. Although the ro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.156

    authors： Villa M,Cerda-Opazo P,Jimenez-Gallegos D,Garrido-Moreno V,Chiong M,Quest AF,Toledo J,Garcia L

    更新日期：2020-04-09 00:00:00

  • A biphasic U-shape effect of cellular oxidative stress on the macrophage anti-oxidant paraoxonase 2 (PON2) enzymatic activity.

    abstract：:Expression of macrophage paraoxonase 2 (PON2), a cellular lactonase with anti-oxidant and anti-atherogenic properties, was shown to be upregulated under high oxidative stress. The aim of the present study was to analyze the relationship between the extent of cellular oxidative stress in J774A.1 macrophage and PON2 lac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.08.150

    authors： Shiner M,Fuhrman B,Aviram M

    更新日期：2006-10-27 00:00:00

  • Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells.

    abstract：:A recent report has shown that in vitro the RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. However, in vivo, it is well known that CGRP receptors are expressed in human coronary arteries and that a beneficial effect is observed in patients after CGRP i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2552

    authors： Frayon S,Cueille C,Gnidéhou S,de Vernejoul MC,Garel JM

    更新日期：2000-04-21 00:00:00

  • Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells.

    abstract：:AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis and its activation during T cell receptor stimulation has recently been reported. In this study, we examined the role of AMPK in interleukin (IL)-2 production in T cells. Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.138

    authors： Jhun BS,Lee JY,Oh YT,Lee JH,Choe W,Baik HH,Kim SS,Yoon KS,Ha J,Kang I

    更新日期：2006-12-29 00:00:00

  • Hepcidin inhibition on the effect of osteogenesis in zebrafish.

    abstract：:Iron overload, as a risk factor for osteoporosis, can result in the up-regulation of Hepcidin, and Hepcidin knockout mice display defects in their bone microarchitecture. However, the molecular and genetic mechanisms underlying Hepcidin deficiency-derived bone loss remain unclear. Here, we show that hepcidin knockdown...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.05.118

    authors： Jiang Y,Yan Y,Wang X,Zhu G,Xu YJ

    更新日期：2016-07-15 00:00:00

  • Studies on the glutathione S-transferase of human platelets.

    abstract：:The glutathione S-transferases of human platelets have been compared with those of erythrocytes. Although wide variations in activity were found, in individual subjects, the activity in these cell types was significantly correlated. The enzymes demonstrated similar isoelectric points and electrophoretic mobilities and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90490-x

    authors： Rogerson KS,Mitchell D,Lawton A,Ibbotson R,Cotton W,Strange RC

    更新日期：1984-07-18 00:00:00

  • Telomere length differences between subcutaneous and visceral adipose tissue in humans.

    abstract：:Adipocyte hypertrophy and hyperplasia have been shown to be associated with shorter telomere length, which may reflect aging, altered cell proliferation and adipose tissue (AT) dysfunction. In individuals with obesity, differences in fat distribution and AT cellular composition may contribute to obesity related metabo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.12.122

    authors： Lakowa N,Trieu N,Flehmig G,Lohmann T,Schön MR,Dietrich A,Zeplin PH,Langer S,Stumvoll M,Blüher M,Klöting N

    更新日期：2015-02-13 00:00:00

  • Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes.

    abstract：:The effects of endothelins (ETs) on the production of stromelysins, a sub-family of matrix metalloproteinases, were examined in cultured astrocytes. The treatment of cultured rat astrocytes with ET-1 increased stromelysin-1 mRNA levels, while stromelysin-2 and -3 mRNAs were not affected. Immunocytochemical observation...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.04.064

    authors： Koyama Y,Tanaka K

    更新日期：2008-07-11 00:00:00

  • Oxygen-evolving enhancer protein 2 is phosphorylated by glycine-rich protein 3/wall-associated kinase 1 in Arabidopsis.

    abstract：:The Arabidopsis wall-associated receptor kinase, WAK1, is a member of WAK family that links the plasma membrane to the extracellular matrix. A glycine-rich secreted protein, AtGRP-3, was previously shown to regulate WAK1 functions through binding to the extracellular domain of WAK1. In this study, we sought to determi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00851-9

    authors： Yang EJ,Oh YA,Lee ES,Park AR,Cho SK,Yoo YJ,Park OK

    更新日期：2003-06-13 00:00:00

  • Deleted in malignant brain tumors 1 protein is a potential biomarker of acute respiratory distress syndrome induced by pneumonia.

    abstract：:Acute respiratory distress syndrome (ARDS) is associated with high mortality and morbidity. Early diagnosis and risk stratification in patients with ARDS should improve prognosis. Unfortunately, no clinical biomarkers are available for use in early diagnosis. Quantitative proteomics is a powerful tool for biomarker di...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.08.125

    authors： Ren S,Chen X,Jiang L,Zhu B,Jiang Q,Xi X

    更新日期：2016-09-23 00:00:00

  • Nuclear localization signals in the core protein of hepatitis C virus.

    abstract：:The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of the HCV core and its beta-galactosidase fusion proteins in transfected cells were examined by indirect immunofluorescence and cyt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2804

    authors： Chang SC,Yen JH,Kang HY,Jang MH,Chang MF

    更新日期：1994-12-15 00:00:00

  • Identification of a lysophosphatidylserine receptor on mast cells.

    abstract：:Lysophosphatidyl-L-serine (lysoPS) is thought to be an immunological regulator because it dramatically augments the degranulation of rat peritoneal mast cells (RPMCs). This stimulatory effect may be mediated by a lysoPS receptor, but its molecule has not been identified yet. During a ligand fishing study for the orpha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.01.069

    authors： Sugo T,Tachimoto H,Chikatsu T,Murakami Y,Kikukawa Y,Sato S,Kikuchi K,Nagi T,Harada M,Ogi K,Ebisawa M,Mori M

    更新日期：2006-03-24 00:00:00

  • Structure and alternative splicing of a heat shock transcription factor gene, MsHSF1, in Medicago sativa.

    abstract：:Plant heat shock transcription factors (HSF) are highly complex. In this study, we identified an alfalfa HSF gene MsHSF1 that is composed of four exons and three introns in the encoding region. The intron1-exon2-intron2-exon3-intron3 as an intervening sequence was inserted at the conserved position that separates the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.10.131

    authors： He ZS,Xie R,Zou HS,Wang YZ,Zhu JB,Yu GQ

    更新日期：2007-12-28 00:00:00

  • Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells.

    abstract：:The vasodilator action of organic nitrates is thought to be mediated by an increase in the level of cGMP following stimulation of the cytosolic enzyme guanylate cyclase in the vascular smooth muscle cell. However, direct evidence for the formation of the putative active metabolite, nitric oxide (NO) within the differe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81290-2

    authors： Feelisch M,Kelm M

    更新日期：1991-10-15 00:00:00

  • Engineered peptides corresponding to segments of the H3 domain of syntaxin inhibit insulin release both in intact and permeabilized mouse pancreatic beta cells.

    abstract：:Syntaxin is one of the proteins involved in the exocytotic event through sequential binding to specific proteins, including SNAP25 and synaptobrevin. In a previous work in digitonin-permeabilized beta cells, we characterized the functional role of two segments: synA and synB of the H3 domain of syntaxin. As a continua...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8923

    authors： Martin F,Salinas E,Barahona F,Vázquez J,Soria B,Reig JA

    更新日期：1998-07-09 00:00:00

  • Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro.

    abstract：:The control of HIV-1 gene expression depends upon interaction of Tat with the trans-activation responsive (TAR) element present at the 5' end of all HIV-1 transcripts. The TAR sequence forms a stable hair-pin structure that binds Tat and several cellular factors in vitro. In the absence of Tat, TAR acts as a transcrip...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2339

    authors： Kaczmarski W,Khan SA

    更新日期：1993-10-29 00:00:00

  • A transcortin-binding protein in the plasma membrane of human syncytiotrophoblast.

    abstract：:Using affinity chromatography on immobilized transcortin of 125I-labeled, cholate-solubilized plasma membranes of human syncytiotrophoblast, a transcortin-binding protein with a minimal Mr of about 20 kDa has been isolated. It was found to be a sialoglycoprotein with an isoelectric point at pH 4.4 (about 5.0 after the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91865-a

    authors： Krupenko SA,Avvakumov GV,Strel'chyonok OA

    更新日期：1991-06-14 00:00:00

  • The cAMP response element binding protein (CREB) is activated by insulin-like growth factor-1 (IGF-1) and regulates myostatin gene expression in skeletal myoblast.

    abstract：:Myostatin, a member of the Transforming Growth Factor beta (TGF-β) superfamily, plays an important role as a negative regulator of skeletal muscle growth and differentiation. We have previously reported that IGF-1 induces a transient myostatin mRNA expression, through the activation of the Nuclear Factor of Activated ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.067

    authors： Zuloaga R,Fuentes EN,Molina A,Valdés JA

    更新日期：2013-10-18 00:00:00

  • Protoporphyrin IX activates the Mg dependent guanylate cyclase from rat liver plasma membranes.

    abstract：:In the presence of Mg-GTP, the rat liver guanylate cyclase, in either intact membranes or trypsin solubilized form, was stimulated by protoporphyrin IX 6 to 10-fold. However, when Mn-GTP was the substrate, protoporphyrin IX activated the membrane-bound guanylate cyclase only 50%, in contrast to the marked activation r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90378-9

    authors： Lacombe ML,Eberentz-Lhomme C

    更新日期：1983-10-14 00:00:00

  • Computational studies of the binding mechanism of calmodulin with chrysin.

    abstract：:Calmodulin (CaM) plays a crucial role in metabolism and physiology of eukaryotes by regulating biological activities. Multiple lines of evidences indicate that the phosphorylated flavonoids possess relatively stronger affinities for proteins by forming non-covalent complexes with them, and that the cellular functions ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.053

    authors： Li L,Wei DQ,Wang JF,Chou KC

    更新日期：2007-07-13 00:00:00

  • Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.

    abstract：:Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β (Aβ), the aggregation of which is known to cause Alzheimer's disease. Therefore, C99 remo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.03.060

    authors： Jang JK,Park KJ,Lee JH,Ko KY,Kang S,Kim IY

    更新日期：2017-04-29 00:00:00