Nitration and chlorination of folic acid by peroxynitrite and hypochlorous acid, and the selective binding of 10-nitro-folate to folate receptor beta.

abstract：:Fiber X-ray diffraction and measurement of fibre dimensions yield information about the effects of a mechanical tension on hydration of DNA in fibres. At a given relative humidity, the mechanical tension changes the DNA conformation but does not modify the number of water molecules associated to a nucleotide. The numb...

journal_title：Biochemical and biophysical research communications

authors： Harmouchi M,Albiser G,Premilat S

更新日期：1992-10-15 00:00:00

abstract：:We have cloned the 5' upstream -1034 to +88 fragment of the human inducible nitric oxide synthase (hiNOS) gene and demonstrate its competence to promote luciferase gene transcription in vascular-smooth-muscle (VSM) cells and macrophages. Sequential 5' end-deletions localized positive regulatory elements of hiNOS trans...

journal_title：Biochemical and biophysical research communications

authors： Kolyada AY,Savikovsky N,Madias NE

更新日期：1996-03-27 00:00:00

abstract：:Free fatty acid (FFA)-bound albumin, which is filtrated through the glomeruli and reabsorbed into proximal tubular cells, is one of the crucial mediators of tubular damage in proteinuric kidney disease. In this study, we examined the role of each kind of FFA on renal tubular damage in vitro and tried to identify its m...

journal_title：Biochemical and biophysical research communications

authors： Soumura M,Kume S,Isshiki K,Takeda N,Araki S,Tanaka Y,Sugimoto T,Chin-Kanasaki M,Nishio Y,Haneda M,Koya D,Kashiwagi A,Maegawa H,Uzu T

更新日期：2010-11-12 00:00:00

abstract：:Npr1 gene (coding for NPR-A) and Npr2 gene (coding for NPR-B) are identified as intrinsic anti-hypertrophic genes that opposes abnormal cardiac remodeling. However, the functional role of Npr1 and Npr2 genes during cardiac hypertrophic growth is not well understood. Hence, the present investigation was aimed to study ...

journal_title：Biochemical and biophysical research communications

authors： Manivasagam S,Vellaichamy E

更新日期：2017-09-16 00:00:00

abstract：:Starch branching enzyme (SBE) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. We determined the crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose at a resolution of 2.2Å. Maltopentaose bound to a hydro...

journal_title：Biochemical and biophysical research communications

authors： Chaen K,Noguchi J,Omori T,Kakuta Y,Kimura M

更新日期：2012-08-03 00:00:00

abstract：:The cytokine interleukin (IL)-17C is highly expressed in epithelial tissues and involved in innate immune responses; however, the regulation of IL-17C expression in the airways remains poorly understood. Here, we show that IL-1β strongly induces both IL-17C mRNA and protein expression in primary normal human bronchial...

journal_title：Biochemical and biophysical research communications

authors： Yamanaka K,Fujisawa T,Kusagaya H,Mori K,Niwa M,Furuhashi K,Kono M,Hamada E,Suda T,Maekawa M

更新日期：2018-01-01 00:00:00

abstract：:Homologous-recombination (HR)-dependent repair defective cells are hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. Combinations of defective HR pathway and PARP inhibitors have been an effective chemotherapeutic modality. We previously showed that knockdown of the WD40-repeat containing protein, Uaf1...

journal_title：Biochemical and biophysical research communications

authors： Choi YE,Park E

更新日期：2015-03-13 00:00:00

abstract：:We have recently reported that synthetic peptide amides corresponding to regions of human FSH beta-subunit, hFSH-beta-(33-53) and hFSH-beta-(81-95), bind to receptor and stimulate estradiol biosynthesis by cultured rat Sertoli cells. Because of experimental difficulties caused by the presence of free sulfhydryl groups...

journal_title：Biochemical and biophysical research communications

authors： Grasso P,Crabb JW,Reichert LE Jr

更新日期：1993-01-15 00:00:00

abstract：:Several studies have demonstrated that allergic asthma can induce atherosclerosis formation in mice. Moreover, allergic asthma and atherosclerosis have been shown to be strongly associated with dyslipidemia. In this study, we investigated the underlying mechanism of allergic asthma-aggravated atherosclerosis-induced c...

journal_title：Biochemical and biophysical research communications

authors： Gao S,Wang C,Li W,Shu S,Zhou J,Yuan Z,Wang L

更新日期：2019-11-19 00:00:00

abstract：:Epitopic peptides representing the C-terminal (HA1) region of cleaved hemagglutinin of influenza virus from different serotypes were synthesized. Circular dichroism and Fourier-transform infrared spectroscopic data showed that peptides HS2 and HS3 have a predominantly alpha-helical conformation in trifluoroethanol. Re...

journal_title：Biochemical and biophysical research communications

authors： Holly S,Majer Z,Tóth GK,Váradi G,Rajnavölgyi E,Laczkó I,Hollósi M

更新日期：1993-06-30 00:00:00

abstract：:The structural changes of the F-actin-myosin head (S1) complex during the cross-bridge cycle are essential in muscle contraction. Although a large body of evidence has accumulated showing that the actin: S1 stoichiometry in the decorated F-actin-S1 filament is 1:1 at saturation by S1, a recent report by Andreev and Bo...

journal_title：Biochemical and biophysical research communications

authors： Carlier MF,Didry D

更新日期：1992-03-31 00:00:00

abstract：:Human AlkB homolog 8 (ALKBH8) is highly expressed in high-grade, superficially and deeply invasive bladder cancer. Moreover, ALKBH8 knockdown induces apoptosis in bladder cancer cells. However, the underlying anti-apoptotic mechanism of ALKBH8 in bladder cancer cells has thus far remained unclear. Moreover, there is n...

journal_title：Biochemical and biophysical research communications

authors： Ohshio I,Kawakami R,Tsukada Y,Nakajima K,Kitae K,Shimanoe T,Saigo Y,Hase H,Ueda Y,Jingushi K,Tsujikawa K

更新日期：2016-08-26 00:00:00

abstract：:Many proteins exhibit strong binding affinities to surfaces, with binding energies much greater than thermal fluctuations. When modelling these protein-surface systems with classical molecular dynamics (MD) simulations, the large forces that exist at the protein/surface interface generally confine the system to a sing...

journal_title：Biochemical and biophysical research communications

authors： Prakash A,Sprenger KG,Pfaendtner J

更新日期：2018-03-29 00:00:00

abstract：:We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors. The receptor consists of 359 residue extracellular domain wh...

journal_title：Biochemical and biophysical research communications

authors： Minegishi T,Nakamura K,Takakura Y,Ibuki Y,Igarashi M,Minegish T corrected to Minegishi T

更新日期：1991-03-29 00:00:00

abstract：:A recently described endo-exodeoxyribonuclease activity (1) was determined to interact preferentially with the origin/enhancer region and the 5' end of the late promoter region of the SV40 mini chromosome. The enzymatic activity has no preferential site of interaction with naked DNA, which suggests, the chromatin orga...

journal_title：Biochemical and biophysical research communications

authors： Quarless SA

更新日期：1985-01-31 00:00:00

abstract：:With the emergence of electrospray ionization mass spectrometry (ESI-MS), mass spectrometry is no longer restricted to the study of small, stable molecules, but has become a viable technique to study large biomolecules as well as noncovalent biomolecular complexes. ESI-MS has been used to study noncovalent interaction...

journal_title：Biochemical and biophysical research communications

authors： Veenstra TD

更新日期：1999-04-02 00:00:00

abstract：:Allelic forms of hGSTP1-1 which differ from each other by their catalytic properties and, structurally, by the amino acid(s) in position(s) 104 or (and) 113 are known to exist in human populations. The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 1...

journal_title：Biochemical and biophysical research communications

authors： Hu X,Xia H,Srivastava SK,Herzog C,Awasthi YC,Ji X,Zimniak P,Singh SV

更新日期：1997-09-18 00:00:00

abstract：:We investigated the regulation of Hsp27 phosphorylation by protein kinase C δ (PKCδ) during etoposide-induced apoptosis. The phosphorylation of Hsp27 at Ser78 was temporally correlated with the proteolytic activation of PKCδ during apoptosis. Hsp27 phosphorylation was dependent on the activity of PKCδ since treatment ...

journal_title：Biochemical and biophysical research communications

authors： Choi JS,Oh JI,Na M,Lee SK,Joo SH

更新日期：2012-10-05 00:00:00

abstract：:DNA bending has been shown to play a critical role in conservative site-specific DNA recombination reactions such as lambda integration. V(D)J recombination, the only mammalian site directed recombination system, is directed by recombinational signal sequences composed of heptamer, nonamer and spacer elements. The non...

journal_title：Biochemical and biophysical research communications

authors： Andrews R,Halligan NL,Halligan BD

更新日期：1993-05-28 00:00:00

abstract：:We have constructed two phagemid vectors containing the gene coding for human Prostate Specific Antigen (PSA) translationally fused to a pelB signal sequence and minor coat protein III of phage fd leading to phage particles that carry PSA on their tips. Phages were characterized by Western blotting and by panning, usi...

journal_title：Biochemical and biophysical research communications

authors： Eerola R,Saviranta P,Lilja H,Pettersson K,Lövgren T,Karp M

更新日期：1994-05-16 00:00:00

abstract：:N-Glycosylation has been shown to affect the rate of glycoprotein transport through the secretory pathway. In order to identify the critical components in the N-glycosylation pathway that directly influence protein secretion, we have studied the effects of downregulation of the first gene in the dolichol pathway, ALG7...

journal_title：Biochemical and biophysical research communications

authors： Kukuruzinska MA,Apekin V,Lamkin MS,Hiltz A,Rodriguez A,Lin CC,Paz MA,Oppenheim FG

更新日期：1994-02-15 00:00:00

abstract：:We have cloned and sequenced rat testis cDNAs coding for a calcium binding polypeptide similar to calcineurin beta subunit, the Ca(2+)-binding subunit of the Ca2+/calmodulin stimulated protein phosphatase. Rat testis cDNA library was screened with a monoclonal antibody Va1 raised against bovine brain calcineurin beta ...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto M,Matsui H,Etoh S,Shimizu T,Nishio H,Moia LJ,Tokuda M,Itano T,Takenaka I,Hatase O

更新日期：1991-11-14 00:00:00

abstract：:Tuberculosis and HIV continue to be the world-leading killers among infectious diseases, primarily affecting poor people in many developing countries. Despite differences in the immunopathogenesis of human infection with tuberculosis and HIV, experimental evidence from clinical studies and relevant animal models can b...

journal_title：Biochemical and biophysical research communications

authors： Brighenti S,Andersson J

更新日期：2010-05-21 00:00:00

abstract：:We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracell...

journal_title：Biochemical and biophysical research communications

authors： Minegishi T,Nakamura K,Takakura Y,Miyamoto K,Hasegawa Y,Ibuki Y,Igarashi M,Minegish T corrected to Minegishi T

更新日期：1990-11-15 00:00:00

abstract：:Thyrotropin receptor (TSHR) in extrathyroidal tissue, especially fat tissue, is supposed to have important roles in the development of extrathyroidal manifestations of Graves' disease. However, the molecular mechanism of TSHR expression is not known. Expression of TSHR mRNA and TSH-dependent cAMP production were obser...

journal_title：Biochemical and biophysical research communications

authors： Haraguchi K,Shimura H,Lin L,Saito T,Endo T,Onaya T

更新日期：1996-06-05 00:00:00

abstract：:How rod-shaped bacteria form and maintain their shape is an important question in bacterial cell biology. Results from fluorescent light microscopy have led many to believe that the actin homolog MreB and a number of other proteins form long helical filaments along the inner membrane of the cell. Here we show using el...

journal_title：Biochemical and biophysical research communications

authors： Swulius MT,Chen S,Jane Ding H,Li Z,Briegel A,Pilhofer M,Tocheva EI,Lybarger SR,Johnson TL,Sandkvist M,Jensen GJ

更新日期：2011-04-22 00:00:00

abstract：:Saccharomyces cerevisiae uso1-1 mutant stops the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus at 37 degrees C. We found that this temperature-sensitive defect was suppressed either by increasing the concentration of calcium ion in the medium or by introducing in the cell the SL...

journal_title：Biochemical and biophysical research communications

authors： Kito M,Seog DH,Igarashi K,Kambe-Honjo H,Yoda K,Yamasaki M

更新日期：1996-03-27 00:00:00

abstract：:Ambroxol is often used as a mucolytic agent in various lung diseases. However, it is unclear how ambroxol acts on bronchial epithelial cells. To clarify the action of ambroxol, we studied the effects of ambroxol on the ion transport in human Calu-3 cells, a human submucosal serous cell line, measuring the transepithel...

journal_title：Biochemical and biophysical research communications

authors： Hasegawa I,Niisato N,Iwasaki Y,Marunaka Y

更新日期：2006-05-05 00:00:00

abstract：:It is noteworthy that the formation of the DNA G-quadruplex is induced by factors other than stabilizing cations because this event probably occurs in living cells. Previous studies have shown that thrombin-binding DNA aptamer (TBA) forms a chair-type intramolecular G-quadruplex structure that binds with thrombin prot...

journal_title：Biochemical and biophysical research communications

authors： Nagatoishi S,Tanaka Y,Tsumoto K

更新日期：2007-01-19 00:00:00

abstract：:Release by phosphatidylinositol-specific phospholipase C is frequently provided as evidence for membrane anchorage of a protein through phosphatidylinositol. Demonstration that the enzyme removes a lipophilic moiety from the protein is stronger evidence, and is presented here for members of the Ly-6 family of lymphocy...

journal_title：Biochemical and biophysical research communications

authors： Hammelburger JW,Palfree RG,Sirlin S,Hämmerling U

更新日期：1987-11-13 00:00:00