Circular dichroism and Fourier-transform infrared spectroscopic studies on T-cell epitopic peptide fragments of influenza virus hemagglutinin.

abstract：:Bone homeostasis is maintained by bone remodeling, which involves continuous bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation of bone turnover, caused by osteoclast overactivation, causes destructive bone diseases. However, the mechanisms underlying the maintenance of osteoclast differen...

journal_title：Biochemical and biophysical research communications

authors： Aoki S,Shimizu K,Ito K

更新日期：2020-07-05 00:00:00

abstract：:Fatty Acid Synthase (FASN), a 250-kDa cytosolic multi-enzyme catalyzing eukaryotic de novo FA biogenesis, unexpectedly localizes in cancer cell culture supernatants and in the blood of cancer patients. High levels of "extracellular FASN" have recently been found in supernatants from Hepatitis C Virus-infected liver ce...

journal_title：Biochemical and biophysical research communications

authors： Oliveras-Ferraros C,Vazquez-Martin A,Fernández-Real JM,Menendez JA

更新日期：2009-01-16 00:00:00

abstract：:Orally ingested botulinum toxin enters the circulatory system and eventually reaches the peripheral nerves, where it elicits a response of neurological dysfunction. In this study, we report the important findings concerning the mechanism of Clostridium botulinum type C progenitor toxin (C16S) endocytic mechanism. C16S...

journal_title：Biochemical and biophysical research communications

authors： Nishikawa A,Uotsu N,Arimitsu H,Lee JC,Miura Y,Fujinaga Y,Nakada H,Watanabe T,Ohyama T,Sakano Y,Oguma K

更新日期：2004-06-25 00:00:00

abstract：:Plant innate immunity varies with age and plant developmental stages. Recently, we reported that Arabidopsis thaliana microRNA miR172b regulates FLS2 transcription through two transcription factors: TARGET OF EAT1 (TOE1) and TOE2. Although the flg22-triggered immune responses were investigated in 2-d-old or even young...

journal_title：Biochemical and biophysical research communications

authors： Zou Y,Wang S,Lu D

更新日期：2020-10-22 00:00:00

abstract：:The eukaryotic primase/polymerase complex synthesizes approximately 107 primers, one per Okazaki fragment, during the replication of mammalian chromosomes, which contain 109 base pairs. Primase catalyzes the synthesis of a short RNA segment to a single-stranded DNA template. Primase is important in DNA replication bec...

journal_title：Biochemical and biophysical research communications

authors： Lee JG,Park KR,An JY,Kang JY,Shen H,Wang J,Eom SH

更新日期：2018-12-09 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as critical regulators of the progression of human cancers, including colorectal cancer (CRC). The study of genome-wide lncRNA expression patterns in metastatic CRC could provide novel mechanism underlying CRC carcinogenesis. In here, we determined the lncRNA expression prof...

journal_title：Biochemical and biophysical research communications

authors： Shen B,Yuan Y,Zhang Y,Yu S,Peng W,Huang X,Feng J

更新日期：2017-06-17 00:00:00

abstract：:A GSH-dependent dehydroascorbate reductase (EC 1.8.5.1) was purified to homogeneity from human erythrocytes. The enzyme was a monomer of 32 kDa and was purified 133-fold from a crude DEAE-Sepharose fraction with a 25% yield. The reduced protein had a pI of 5.1 as judged by isoelectric focusing. Kinetic analysis gave a...

journal_title：Biochemical and biophysical research communications

authors： Xu DP,Washburn MP,Sun GP,Wells WW

更新日期：1996-04-05 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] initiates the hydrolysis of sphingomyelin in ROS 17/2.8 osteosarcoma cells with the resultant generation of cell-associated ceramide. Increases in ceramide levels were detectable at 15 min and maximal one hour after exposure of cells to 1,25(OH)(2)D(3). Neither 1,25(OH)(2)D...

journal_title：Biochemical and biophysical research communications

authors： Liu R,Xu Y,Farach-Carson MC,Vogel JJ,Karin NJ

更新日期：2000-06-24 00:00:00

abstract：:P-glycoprotein (P-gp) is required for adaptive immunity through defined functions in T cell activation and antigen presenting cell (APC) maturation. The potential role of P-gp as an in vivo regulator of alloimmunity is currently unknown. Here we show that P-gp blockade prolongs graft survival in a murine heterotopic c...

journal_title：Biochemical and biophysical research communications

authors： Izawa A,Schatton T,Frank NY,Ueno T,Yamaura K,Pendse SS,Margaryan A,Grimm M,Gasser M,Waaga-Gasser AM,Sayegh MH,Frank MH

更新日期：2010-04-09 00:00:00

abstract：:Interest in lipoamino acids as endogenous modulators of G-protein coupled receptors has escalated due to their involvement in a variety of physiologic processes. In particular, a role for these amino acid conjugates has emerged in the endocannabinoid system. The study presented herein investigated the effects of N-ara...

journal_title：Biochemical and biophysical research communications

authors： Console-Bram L,Ciuciu SM,Zhao P,Zipkin RE,Brailoiu E,Abood ME

更新日期：2017-09-02 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (RB) is inactivated in a majority of cancers. RB restricts cell proliferation by inhibiting the E2F family of transcription factors. The current model for RB/E2F function describes its role in regulating transcription at gene promoters. Whether the RB or E2F proteins might p...

journal_title：Biochemical and biophysical research communications

authors： Ahlander J,Bosco G

更新日期：2009-07-03 00:00:00

abstract：:Diffuse panbronchiolitis (DPB) is a chronic progressive disease of the respiratory bronchioles, and has been improved by low-dose, long-term erythromycin (EMC) treatment. The therapeutic benefits may be derived from its anti-inflammatory and immunomodulatory properties rather than antimicrobial effect. However, there ...

journal_title：Biochemical and biophysical research communications

authors： Park SJ,Lee YC,Rhee YK,Lee HB

更新日期：2004-11-05 00:00:00

abstract：:Thrombin induced tyrosine phosphorylation of 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases in human platelets which was detectable at 1 min and peaked at 2 min after thrombin stimulation as assessed by immunoprecipitation and immunoblotting. The kinase activity, measured by phosphorylation of myelin basic ...

journal_title：Biochemical and biophysical research communications

authors： Nakashima S,Chatani Y,Nakamura M,Miyoshi N,Kohno M,Nozawa Y

更新日期：1994-01-28 00:00:00

abstract：:Mg2+ is essential for guanosine triphosphatase activity and plays key roles in guanine nucleotide binding and preserving the structural integrity of GTP-binding proteins. To understand the structural basis for Mg2+ function during the GDP/GTP exchange process, we determined the crystal structure of Delta9-Sar1-GDP at ...

journal_title：Biochemical and biophysical research communications

authors： Rao Y,Bian C,Yuan C,Li Y,Chen L,Ye X,Huang Z,Huang M

更新日期：2006-09-29 00:00:00

abstract：:Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of diabetes characterized by early onset of pancreatic dysfunction. MODY type 3 is caused by mutations in the hepatocyte nuclear factor (HNF)-1alpha. During a screening of Norwegian patients with suspected MODY we identified two novel HNF-1alpha...

journal_title：Biochemical and biophysical research communications

authors： Bjørkhaug L,Ye H,Horikawa Y,Søvik O,Molven A,Njølstad PR

更新日期：2000-12-29 00:00:00

abstract：:Distribution of mRNA expression of 1,25-dihydroxyvitamin D3 receptor (VDR) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase) along the microdissected rat nephron segments was examined by reverse transcription-polymerase chain reaction (RT-PCR) technique. VDR mRNA was abundantly expressed in cortical segments (glomeru...

journal_title：Biochemical and biophysical research communications

authors： Iida K,Taniguchi S,Kurokawa K

更新日期：1993-07-30 00:00:00

abstract：:Irradiation induces severe damage in the hematopoietic system, which leads to bone marrow hyperplasia, pancytopenia, and aggravated tissue formation in bone marrow. Studies have shown that Toll-like receptor 4 (TLR4) has a protective effect against irradiation, but the underlying mechanism remains unclear. In this stu...

journal_title：Biochemical and biophysical research communications

authors： Sun Z,Wu K,Lin Q,Fei H,Jiang H,Chen T,Yuan Y

更新日期：2019-12-03 00:00:00

abstract：:A new eukaryotic initiation factor 2 kinase has been purified for the first time from calf brain cytosol. The purification of a nonabundant novel protein kinase activity, designated as PKI, that phosphorylates the alpha subunit of eukaryotic initiation factor 2 is described. The protein kinase activity was assayed usi...

journal_title：Biochemical and biophysical research communications

authors： Alcázar A,Méndez E,Martín ME,Salinas M

更新日期：1990-02-14 00:00:00

abstract：:Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating antioxidant responses. The present study aimed to explore...

journal_title：Biochemical and biophysical research communications

authors： Xing L,Guo H,Meng S,Zhu B,Fang J,Huang J,Chen J,Wang Y,Wang L,Yao X,Wang H

更新日期：2021-01-01 00:00:00

abstract：:Aggregation of amyloid beta-peptide (Abeta), a key pathological event in Alzheimer's disease, has been shown in vitro to be profoundly promoted by Zn(II). This fact suggests that some factors in the normal brain protect Abeta from the Zn(II)-induced aggregation. We demonstrate for the first time that Cu(II) effectivel...

journal_title：Biochemical and biophysical research communications

authors： Suzuki K,Miura T,Takeuchi H

更新日期：2001-07-27 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK3beta) is recognized as one of major kinases to phosphorylate tau in Alzheimer's disease (AD), thus lots of AD drug discoveries target GSK3beta. However, the inactive form of GSK3beta which is phosphorylated at serine-9 is increased in AD brains. This is also inconsistent with phosph...

journal_title：Biochemical and biophysical research communications

authors： Lim YW,Yoon SY,Choi JE,Kim SM,Lee HS,Choe H,Lee SC,Kim DH

更新日期：2010-04-30 00:00:00

abstract：:It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-...

journal_title：Biochemical and biophysical research communications

authors： Kajiya M,Sato K,Silva MJ,Ouhara K,Do PM,Shanmugam KT,Kawai T

更新日期：2009-08-21 00:00:00

abstract：:Sma- and MAD-related protein 3 (Smad3) plays crucial roles in the transforming growth factor-beta (TGF-beta)-mediated signaling pathway, which produce a variety of cellular responses, including cell proliferation and differentiation. In our previous study, we demonstrated that protein inhibitor of activated STATy (PIA...

journal_title：Biochemical and biophysical research communications

authors： Imoto S,Ohbayashi N,Ikeda O,Kamitani S,Muromoto R,Sekine Y,Matsuda T

更新日期：2008-05-30 00:00:00

abstract：:The importance of Trp 800 in the calmodulin-binding site of myosin light chain kinase was investigated. Truncation mutants from Leu 447 to the C-terminus were expressed in E. coli and these were modified by point mutations of Trp 800 to Gly, Cys, Leu and Tyr. Trp at this position was more effective than any of the oth...

journal_title：Biochemical and biophysical research communications

authors： Matsushima S,Huang YP,Dudas CV,Guerriero V Jr,Hartshorne DJ

更新日期：1994-08-15 00:00:00

abstract：AIMS:Insulin-like growth factor-1 (IGF-1) is a polypeptide protein hormone, similar in molecular structure to insulin, which plays an important role in cell migration, cell cycle progression, cell survival and proliferation. In this study, we investigated the possible mechanisms of IGF-1 mediated cell cycle redistribut...

journal_title：Biochemical and biophysical research communications

authors： Ma QL,Yang TL,Yin JY,Peng ZY,Yu M,Liu ZQ,Chen FP

更新日期：2009-11-06 00:00:00

abstract：:The direct interaction of protein kinase C with the nucleus was examined utilizing endogenous protein phosphorylation and [3H]PDBu binding to detect the enzyme. Rat brain nuclei were relatively rich in phorbol ester receptors whereas liver nuclei contained less than 10% of their brain counterpart. Purified protein kin...

journal_title：Biochemical and biophysical research communications

authors： Misra UK,Sahyoun N

更新日期：1987-06-15 00:00:00

abstract：:We investigated the regulation of Hsp27 phosphorylation by protein kinase C δ (PKCδ) during etoposide-induced apoptosis. The phosphorylation of Hsp27 at Ser78 was temporally correlated with the proteolytic activation of PKCδ during apoptosis. Hsp27 phosphorylation was dependent on the activity of PKCδ since treatment ...

journal_title：Biochemical and biophysical research communications

authors： Choi JS,Oh JI,Na M,Lee SK,Joo SH

更新日期：2012-10-05 00:00:00

abstract：:It is controversial whether osteopontin (OP) is expressed in glomeruli and involved in glomerular diseases. We examined whether the OP expression is present at gene and protein levels in cultured rat mesangial cells (MCs). Northern blotting revealed a 1.7 kb OP-mRNA expression in MCs. Fetal calf serum (FCS) and TNF-al...

journal_title：Biochemical and biophysical research communications

authors： Nagasaki T,Ishimura E,Shioi A,Jono S,Inaba M,Nishizawa Y,Morii H,Otani S

更新日期：1997-04-07 00:00:00

abstract：:Synthesis of ABCA1 protein in liver is necessary for high-density lipoproteins (HDL) formation in mammals. Nuclear receptor PPARγ is known as activator of ABCA1 expression, but details of PPARγ-mediated regulation of ABCA1 at both transcriptional and post-transcriptional levels in hepatocytes have not still been well ...

journal_title：Biochemical and biophysical research communications

authors： Mogilenko DA,Shavva VS,Dizhe EB,Orlov SV,Perevozchikov AP

更新日期：2010-11-19 00:00:00

abstract：:Arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications and early death. However, the underling mechanisms of arthritis are still unclear. Sirtuins are a NAD(+)-dependent class III deacetylase family, and regulate cellular stress, inflammation, genomic stability,...

journal_title：Biochemical and biophysical research communications

authors： Lin J,Sun B,Jiang C,Hong H,Zheng Y

更新日期：2013-11-29 00:00:00