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Demonstration of histamine H2 receptors on human melanoma cells.

Abstract：

:Histamine induced a concentration-dependent increase in intracellular cyclic-AMP of the two human melanoma cell lines SK23 and DX3.LT5.1; maximal stimulation was obtained with 17.8 microM histamine which consistently produced greater than 50-fold increases in the cyclic AMP content of both cell lines. The dose-response curve for histamine in each culture was progressively displaced to the right with increasing concentrations of the histamine H2 receptor antagonist cimetidine. Ranitidine, another H2 receptor antagonist also prevented the histamine-induced cyclic AMP elevation, but the H1 receptor antagonists mepyramine and tripelennamine had no significant effect. These findings indicate that human melanoma cells express histamine H2 receptors, stimulation of which activates adenylate cyclase with a subsequent rise in intracellular cyclic AMP. Mast cell:melanoma interactions mediated by histamine in vivo might therefore be expected to modify some aspects of melanoma cell behaviour.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Whitehead RJ,Taylor DJ,Evanson JM,Hart IR,Woolley DE

doi

10.1016/0006-291x(88)90624-9

subject

Has Abstract

pub_date

1988-02-29 00:00:00

pages

518-23

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90624-9

journal_volume

151

pub_type

杂志文章

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