Identification of cyclic AMP response element in the human renin gene.

abstract：OBJECTIVE:The aim of this study was to determine whether ATP-binding cassette transporter A1 (ABCA1) was up-regulated by growth differentiation factor-15 (GDF-15) via the phosphoinositide 3-kinase (PI3K)/protein kinase Cζ (PKCζ)/specificity protein 1 (SP1) pathway in THP-1 macrophages. METHODS AND RESULTS:We investiga...

journal_title：Biochemical and biophysical research communications

authors： Wu JF,Wang Y,Zhang M,Tang YY,Wang B,He PP,Lv YC,Ouyang XP,Yao F,Tan YL,Tang SL,Tang DP,Cayabyab FS,Zheng XL,Zhang DW,Zeng GF,Tang CK

更新日期：2014-02-14 00:00:00

abstract：:Experimental studies have demonstrated the beneficial effects of tetramethylpyrazine (TMP) against ischemic stroke and highlighted its crucial role in anti-inflammatory activity. This study provides evidence of an alternative target for TMP and sheds light on the mechanism of its anti-inflammatory action against ische...

journal_title：Biochemical and biophysical research communications

authors： Chang CY,Kao TK,Chen WY,Ou YC,Li JR,Liao SL,Raung SL,Chen CJ

更新日期：2015-07-31 00:00:00

abstract：:A two-component regulatory system involving StyS and StyR is involved in the regulation of indigo synthesis in Pseudomonas sp. However, the function of the styR gene in indigo synthesis and the detailed mechanisms through which StyR enhances the expression of the styAB operon are unclear. Accordingly, in this study, w...

journal_title：Biochemical and biophysical research communications

authors： Cheng L,Yue J,Yin S,Ren M,Wang C

更新日期：2019-10-29 00:00:00

abstract：:Caveolae are cholesterol enriched invaginations of the plasma membrane involved in a variety of processes, including glucose and fatty acids absorption, cell transduction and mechanoprotection. The biogenesis and function of caveolae depend on the activity of Caveolin (Cav-1, -2 and -3) and Cavin (Cavin-1, -2, -3 and ...

journal_title：Biochemical and biophysical research communications

authors： Codenotti S,Vezzoli M,Poliani PL,Cominelli M,Monti E,Fanzani A

更新日期：2017-11-04 00:00:00

abstract：:To correlate structural data on substrates of human fibroblast collagenase with their interaction with the enzyme, we have studied: Ac-PLG-s-LLG-O-ethyl ester (I), Dnp-PLGLWA(d-Arg)-NH2 (II), AcGPEGLRVG-O-ethyl ester (III) and Succ-GPLGP-O-amidomethylcoumaryl ester (IV). Peptides I and II represent collagenase cleavag...

journal_title：Biochemical and biophysical research communications

authors： Upadhye S,Ananthanarayanan VS

更新日期：1995-10-13 00:00:00

abstract：:Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feat...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Chen X,Zhang M,Luo Z

更新日期：2020-03-26 00:00:00

abstract：:Pluripotent human embryonic stem cells (hESCs) have the distinguishing feature of innate capacity to allow indefinite self-renewal. This attribute continues until specific constraints or restrictions, such as DNA methylation, are imposed on the genome, usually accompanied by differentiation. With the aim of utilizing ...

journal_title：Biochemical and biophysical research communications

authors： Yeo S,Jeong S,Kim J,Han JS,Han YM,Kang YK

更新日期：2007-08-03 00:00:00

abstract：:The second leader exon and the relative promoter of the mouse liver/bone/kidney-type alkaline phosphatase gene were identified and characterized. The transcription initiation site was determined by S1 mapping analysis. The differential expression of the two alternatively spliced transcripts was assessed in cell lines ...

journal_title：Biochemical and biophysical research communications

authors： Studer M,Terao M,Gianni M,Garattini E

更新日期：1991-09-30 00:00:00

abstract：:Triticone A is one member of a family of novel compounds which are spirocyclic lactams produced by several plant pathogenic fungi including Drechslera tritici repentis on wheat. It undergoes racemization to form triticone B and when tested, the enantiomeric mixture causes chlorosis and necrosis on a wide range of plan...

journal_title：Biochemical and biophysical research communications

authors： Kenfield D,Strobel S,Sugawara F,Berglund D,Strobel G

更新日期：1988-11-30 00:00:00

abstract：:For influenza H5N1 hemagglutinin, a switch from SA-alpha-2, 3-Gal to SA-alpha-2, 6-Gal receptor specificity is a critical step leading to the conversion from avian-to-human to human-to-human infection. Therefore, the understanding of the binding modes of SA-alpha-2, 3-Gal and SA-alpha-2, 6-Gal to H5N1 hemagglutinin wi...

journal_title：Biochemical and biophysical research communications

authors： Li M,Wang B

更新日期：2006-09-01 00:00:00

abstract：:Sugarcane (Saccharum sp. hybrid) provides the main source of sugar for humans. Sugarcane mosaic disease (SMD) is a major threat to sugarcane production. Currently, control of SMD is mainly dependent on breeding resistant cultivars through hybridization, which is time-consuming. Understanding the mechanism of viral inf...

journal_title：Biochemical and biophysical research communications

authors： Zhai Y,Deng Y,Cheng G,Peng L,Zheng Y,Yang Y,Xu J

更新日期：2015-10-23 00:00:00

abstract：:Galectins (gal), a family of soluble beta-galactoside-binding proteins present at the cell surface, are involved in cancer progression and metastasis. Here we investigated the expression of several galectins in normal (PrEC), benign (BPH-1), and malignant (LNCaP) prostate epithelial cells and found that all galectins,...

journal_title：Biochemical and biophysical research communications

authors： Ahmed H,Banerjee PP,Vasta GR

更新日期：2007-06-22 00:00:00

abstract：:The rfp/ret transforming gene was generated by DNA rearrangement which occurred during transfection of NIH 3T3 cells. The amino-terminal half of Rfp with a RING finger motif was fused to the truncated Ret receptor tyrosine kinase, leading to a transforming sequence, Rfp/Ret. In the present study, to elucidate the impo...

journal_title：Biochemical and biophysical research communications

authors： Hasegawa N,Iwashita T,Asai N,Murakami H,Iwata Y,Isomura T,Goto H,Hayakawa T,Takahashi M

更新日期：1996-08-14 00:00:00

abstract：:The presence and localization of mitochondrial calmodulin was directly proved immuno-electron microscopically by the protein A-gold technique. In the ultra-pure mitochondria the complexes of anti-calmodulin antibody and protein A-gold clearly showed the localization of mitochondrial calmodulin on the inner membrane an...

journal_title：Biochemical and biophysical research communications

authors： Hatase O,Doi A,Itano T,Matsui H,Ohmura Y

更新日期：1985-10-15 00:00:00

abstract：:The ATP-sensitive potassium channel of insulin-secreting pancreatic beta-cells is a complex of Kir6.2, a member of the inwardly rectifying potassium channel superfamily, and the sulfonylurea receptor. We have isolated cDNA clones encoding rat Kir6.2. Co-expression of rat Kir6.2 and sulfonylurea receptor in human embry...

journal_title：Biochemical and biophysical research communications

authors： Tokuyama Y,Fan Z,Furuta H,Makielski JC,Polonsky KS,Bell GI,Yano H

更新日期：1996-03-27 00:00:00

abstract：:Triacsin C, a product of Streptmyces sp. SK-1894, was previously reported as an inhibitor of long chain acyl-CoA synthetase. Pretreatment with triacsin C (500 nM) for 1h enhanced production of platelet-activating factor in rat neutrophils, followed by stimulation with A23187 or fMLP. Amount of lyso-PAF was also augume...

journal_title：Biochemical and biophysical research communications

authors： Hayashi M,Imai Y,Naraba H,Tomoda H,Omura S,Oh-ishi S

更新日期：1992-11-16 00:00:00

abstract：:In order to examine the ability of an O-glycosylated serine residue preceding proline to stabilize a cis amide conformation in a fashion similar to that observed with aromatic amino acid residues, we prepared a series of glycosylated analogs of a small linear peptide which we have previous reported to contain a cis co...

journal_title：Biochemical and biophysical research communications

authors： Pao YL,Wormarld MR,Dwek RA,Lellouch AC

更新日期：1996-02-06 00:00:00

abstract：:Xenopus XmN-cadherin gene appears to have dual functions, since its mRNA is maternally provided in unfertilized eggs, once disappears almost completely during gastrula stage, then accumulates again specifically in neural tissues in later stage embryos. In the present experiment, we first followed the change in XmN-cad...

journal_title：Biochemical and biophysical research communications

authors： Hojyo T,Tooi O,Tashiro K,Shiokawa K

更新日期：1998-01-06 00:00:00

abstract：:Recent studies suggest important roles for long noncoding RNAs as essential regulators of human cancer. GClnc1 was found to be upregulated in gastric cancer, playing oncogenic roles. However, the biological function and underlying mechanism of GClnc1 in osteosarcoma (OS) remain unclear. Here, we report that GClnc1 is ...

journal_title：Biochemical and biophysical research communications

authors： Sui Y,Han Y,Zhao X,Li D,Li G

更新日期：2018-12-09 00:00:00

abstract：:Hemorrhagic snake venom induces apoptosis of vascular endothelial cells [S. Araki, T. Ishida, T. Yamamoto, K. Kaji, and H. Hayashi (1993) Biochem. Biophys. Res. Comm. 190 , 148-153]. We have identified that a cytotoxic substance of Korean snake venom which is responsible for the apoptosis is L-amino acid oxidase (LAO)...

journal_title：Biochemical and biophysical research communications

authors： Suhr SM,Kim DS

更新日期：1996-07-05 00:00:00

abstract：:Special AT-rich sequence-binding protein (SATB) plays a critical role in bone generation and osteoblast differentiation. In the present study, the differentially expressed genes by SATB2 overexpression were analyzed in MC3T3-E1 osteoblast-like cells using Alizarin red S staining, wound healing assay and Agilent's Huma...

journal_title：Biochemical and biophysical research communications

authors： Kim IS,Jeong SJ,Kim SH,Jung JH,Park YG,Kim SH

更新日期：2012-01-13 00:00:00

abstract：:trans-Resveratrol (3,4',5-trihydroxystilbene; RES), a polyphenol found in particularly high concentrations in red wine, has recently attracted intense interest for its potentially beneficial effects on human health. Here, we report the effects of long-term exposure to micromolar concentrations of RES on antioxidant an...

journal_title：Biochemical and biophysical research communications

authors： Robb EL,Page MM,Wiens BE,Stuart JA

更新日期：2008-03-07 00:00:00

abstract：:Cell-free translation is one potential approach to the production of functional transmembrane proteins. We have now examined various detergents as supplements to a wheat-germ cell-free system in order to optimize the production and subsequent purification of a functional model transmembrane protein, bacteriorhodopsin....

journal_title：Biochemical and biophysical research communications

authors： Genji T,Nozawa A,Tozawa Y

更新日期：2010-10-01 00:00:00

abstract：:The ability of two 15-ketosubstituted sterols, 5alpha-cholest-8(14)-en-3beta-ol-15-one and 3beta-(2-hydroxyethoxy)-5alpha-cholest-8(14)-en-15-one, to alter the mRNA levels of 3-hydroxy-3-methylglutaryl-CoA reductase, low density lipoprotein receptor, and oxysterol binding protein was studied and compared with the effe...

journal_title：Biochemical and biophysical research communications

authors： Kisseleva AF,Goryunova LE,Planells R,Lafont H,Alquier C

更新日期：1999-06-16 00:00:00

abstract：:Yes-associated protein (YAP) is a key downstream effector of the highly conserved Hippo signaling pathway, which regulates organ size, regeneration and tumorigenesis. Known classically to function as a transcriptional co-activator, YAP interacts with TEA domain transcription factors (TEAD1-4) to induce expression of t...

journal_title：Biochemical and biophysical research communications

authors： Wen Z,Wang Y,Qi S,Ma M,Li J,Yu FX

更新日期：2020-10-15 00:00:00

abstract：:8-iso-PGE2, an E2-isoprostane, decreased GFR and RPF dose-dependently in rats, but with lesser potency than 8-epi-PGF2 alpha, an F2-isoprostane. This effect was abolished by SQ29,548. 8-iso-PGE2 displaced [3H]SQ29,548 or [125I]BOP binding in aortic smooth muscle cells with the affinity rank order of SQ29,548 > = I-BOP...

journal_title：Biochemical and biophysical research communications

authors： Fukunaga M,Takahashi K,Badr KF

更新日期：1993-09-15 00:00:00

abstract：:Expression of macrophage paraoxonase 2 (PON2), a cellular lactonase with anti-oxidant and anti-atherogenic properties, was shown to be upregulated under high oxidative stress. The aim of the present study was to analyze the relationship between the extent of cellular oxidative stress in J774A.1 macrophage and PON2 lac...

journal_title：Biochemical and biophysical research communications

authors： Shiner M,Fuhrman B,Aviram M

更新日期：2006-10-27 00:00:00

abstract：:Glycosylation mutants of chinese hamster ovary cells were used to analyse the role played by surface-exposed carbohydrates on the process of interaction of Trypanosoma cruzi with the host cell. Adhesion and invasion of the parasites were markedly reduced in cells which express very few sialic acid residues. Infection ...

journal_title：Biochemical and biophysical research communications

authors： Ciavaglia Mdo C,de Carvalho TU,de Souza W

更新日期：1993-06-15 00:00:00

abstract：:Despite its utility, dipeptides have not been widely used due to the absence of an efficient manufacturing method. Recently, a novel method for effective production of dipeptides using l-amino acid alpha-ligase (Lal) is presented. Lal, which is only identified in Bacillus subtilis, catalyzes dipeptide synthesis from u...

journal_title：Biochemical and biophysical research communications

authors： Kino K,Nakazawa Y,Yagasaki M

更新日期：2008-07-04 00:00:00

abstract：:To investigate the role of inositol phospholipid turnover in the atrial natriuretic peptide (ANP) secretion, the secretory responses from isolated perfused rat hearts to the ionophore, A23187, and the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), alone or in combination, were studied. A23187 induced a sha...

journal_title：Biochemical and biophysical research communications

authors： Ruskoaho H,Toth M,Lang RE

更新日期：1985-12-17 00:00:00