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Triticone A: a novel bioactive lactam with potential as a molecular probe.

Abstract：

:Triticone A is one member of a family of novel compounds which are spirocyclic lactams produced by several plant pathogenic fungi including Drechslera tritici repentis on wheat. It undergoes racemization to form triticone B and when tested, the enantiomeric mixture causes chlorosis and necrosis on a wide range of plants. Fluorescein diacetate treated protoplasts in conjunction with various triticone treatments allowed for accurate quantitation of the biological activity of the toxin. Various physiological functions of the wheat cell are impaired including the Hill and CO2 fixation reactions in photosynthesis. In addition, triticone A inhibits enzymes that have SH functional groups as part of their active site, eg., the protease-ficin. Neither triticone C or D had any activity in the enzyme or protoplast assays. It is apparent that triticone A has some potential as a molecular probe in a variety of biological systems.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kenfield D,Strobel S,Sugawara F,Berglund D,Strobel G

doi

10.1016/s0006-291x(88)80029-9

subject

Has Abstract

pub_date

1988-11-30 00:00:00

pages

174-82

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80029-9

journal_volume

157

pub_type

杂志文章

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