Stoichiometric carboxyl methylation of chromogranins from bovine adrenal medullary cells.

abstract：:Glycyrrhetinic acid (GA), a triterpene saponins, has been widely proven to have multiple medicinal properties. Our study aimed to figure out the protective effect of GA on acute lung injury (ALI) and the underlying mechanism. The LPS-induced ALI model mice were intratracheally administrated with 10 mg/kg LPS. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Wang K,Zhang Y,Cao Y,Shi Z,Lin Y,Chen Y,Zhao H,Liu X

更新日期：2020-11-19 00:00:00

abstract：:Free fatty acid (FFA)-bound albumin, which is filtrated through the glomeruli and reabsorbed into proximal tubular cells, is one of the crucial mediators of tubular damage in proteinuric kidney disease. In this study, we examined the role of each kind of FFA on renal tubular damage in vitro and tried to identify its m...

journal_title：Biochemical and biophysical research communications

authors： Soumura M,Kume S,Isshiki K,Takeda N,Araki S,Tanaka Y,Sugimoto T,Chin-Kanasaki M,Nishio Y,Haneda M,Koya D,Kashiwagi A,Maegawa H,Uzu T

更新日期：2010-11-12 00:00:00

abstract：:15-Deoxy-prostaglandin J(2)(15d-PGJ(2)) is an endogenous ligand of peroxisome proliferator-activated receptor gamma (PPARgamma) and plays an important role in the regulation of endothelial cell growth and apoptosis. However, the detailed mechanisms are poorly understood. We hypothesized that 15d-PGJ(2) might affect PD...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Fu M,Zhao L,Chen YE

更新日期：2002-10-18 00:00:00

abstract：:Glypican-4 (Gpc4) has been found to play an important role in enhancing miniature excitatory postsynaptic currents (mEPSCs). But, the relationship between Gpc4 and epilepsy is still a mystery. In this study, we investigated the expression patterns of Gpc4 in patients with epilepsy and in a pilocarpine-induced rat mode...

journal_title：Biochemical and biophysical research communications

authors： Xiong Y,Zhang Y,Zheng F,Yang Y,Xu X,Wang W,Zhu B,Wang X

更新日期：2016-09-09 00:00:00

abstract：:Phosphoglycerate mutase is inactivated by butanedione in borate buffer. Inactivation by 0.13 mM reagent correlates with the modification of one arginyl residue per subunit, and is prevented by either 2, 3-diphosphoglycerate or 3-phosphoglycerate. With 0.50 mM butanedione, inactivation is accompanied by the modificatio...

journal_title：Biochemical and biophysical research communications

authors： Borders CL Jr,Wilson BA

更新日期：1976-12-20 00:00:00

abstract：:We describe a novel technology for detecting nucleic acids: Probe Alteration Link Self-Assembly Reactions (PALSAR). PALSAR comprises DNA self-assembly of pairs of short DNA probes formed by alternate hybridization of three complementary regions in a pair of honeycomb probes (HCPs). Self-assembly occurs at designated s...

journal_title：Biochemical and biophysical research communications

authors： Usui M,Fujikawa T,Osawa M,Hakii C,Ikumi N,Nozaki T,Kitamura N,Hatta Y,Fujiwara S,Takei M

更新日期：2015-11-27 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels assembled from four subunits that each have a common membrane topology. The intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least conserved between subunits, and binds multiple intracellular proteins. We defined ...

journal_title：Biochemical and biophysical research communications

authors： Bajaj G,Hau AM,Hsu P,Gafken PR,Schimerlik MI,Ishmael JE

更新日期：2014-02-21 00:00:00

abstract：:To maintain immune homeostasis in the intestine, the intestinal immune system has evolved several tolerogenic mechanisms toward intestinal microflora and food antigens. Although programmed cell death-1 (PD-1) protein has been implicated in immunological tolerance in the intestine and gut-associated lymphoid tissues (G...

journal_title：Biochemical and biophysical research communications

authors： Doi T,Kanai T,Mikami Y,Sujino T,Jun L,Ono Y,Hayashi A,Hibi T

更新日期：2012-09-07 00:00:00

abstract：:We present an easy and sensitive method for measuring thiamine and its phosphate esters in small biological samples of microalgae (Amphidinium carterae Hulburt and Nitzschia microcephala Grun). The method consists of extraction of thiamine and its derivatives in acid solution, followed by liquid chromatography with fl...

journal_title：Biochemical and biophysical research communications

authors： Pinto E,Pedersén M,Snoeijs P,Van Nieuwerburgh L,Colepicolo P

更新日期：2002-02-22 00:00:00

abstract：:Apoptosis is a well defined physiological process characterised by many specific features including DNA fragmentation and protease activation. Cell membrane-associated changes such as the altered exposure of phosphatidylserine and glycosylation patterns have also been described. We investigate here the change in expos...

journal_title：Biochemical and biophysical research communications

authors： Russell L,Waring P,Beaver JP

更新日期：1998-09-18 00:00:00

abstract：:Poly(ADP-ribose) glycohydrolase (PARG) is a major enzyme that plays a role in the degradation of poly(ADP-ribose) (PAR). PARG deficiency reportedly sensitizes cells to the effects of radiation. In lung cancer, however, it has not been fully elucidated. Here, we investigated whether PARG siRNA contributes to an increas...

journal_title：Biochemical and biophysical research communications

authors： Nakadate Y,Kodera Y,Kitamura Y,Tachibana T,Tamura T,Koizumi F

更新日期：2013-11-29 00:00:00

abstract：:The reaction of peroxynitrite anion (O=N-OO-) with CO2 results in the formation of an unstable nitrosoperoxycarbonate anion adduct, O=N-OOCO-2 (1). Adduct 1 can serve as a source for several reactive intermediates, including the nitrocarbonate anion (O2N-OCO-2), the carbonate radical ion/nitrogen dioxide radical pair,...

journal_title：Biochemical and biophysical research communications

authors： Uppu RM,Pryor WA

更新日期：1996-12-24 00:00:00

abstract：:This study investigates the transcriptional role of the human mitochondrial carnitine/acylcarnitine carrier (CAC) proximal promoter. Through deletion analysis, an activation domain (-334/-80 bp) was identified which contains FOXA and Sp1 active sites. The wild-type (but not mutated) -334/-80 bp region of the CAC gene ...

journal_title：Biochemical and biophysical research communications

authors： Convertini P,Infantino V,Bisaccia F,Palmieri F,Iacobazzi V

更新日期：2011-01-07 00:00:00

abstract：:DR4, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor, is a key element in the extrinsic pathway of TRAIL/TRAIL receptor-related apoptosis that exerts a preferential toxic effect against tumor cells. However, TRAIL and DR4 are expressed in various normal cells, and recent studies indicate tha...

journal_title：Biochemical and biophysical research communications

authors： Kang MS,Lee SK,Park CS,Kang JH,Bae SH,Yu SL

更新日期：2008-11-14 00:00:00

abstract：:During the late stage of homologous recombination in prokaryotes, RuvA binds to the Holliday junction intermediate and executes branch migration in association with RuvB. The RuvA subunits form two distinct complexes with the Holliday junction: complex I with the single RuvA tetramer on one side of the four way juncti...

journal_title：Biochemical and biophysical research communications

authors： Mayanagi K,Fujiwara Y,Miyata T,Morikawa K

更新日期：2008-01-11 00:00:00

abstract：:We have investigated the angiogenic effects of basic fibroblast growth factor following its implantation in slow release beads under the kidney capsule. The presence of basic fibroblast growth factor in the subcapsular space induced a marked angiogenic response maximal at 1 microgram dose per kidney. Histological exam...

journal_title：Biochemical and biophysical research communications

authors： Hayek A,Culler FL,Beattie GM,Lopez AD,Cuevas P,Baird A

更新日期：1987-09-15 00:00:00

abstract：:Adenosine, a metabolite of ATP, ubiquitously exists in a wide range of organs and tissues. We previously reported that adenosine was implicated in apoptosis in many cancer cells by extrinsic and/or intrinsic pathways. Here, we found that adenosine suppresses the cell growth by induction of apoptosis of human colonic c...

journal_title：Biochemical and biophysical research communications

authors： Yu S,Hou D,Chen P,Zhang Q,Lv B,Ma Y,Liu F,Liu H,Song EJ,Yang D,Liu J

更新日期：2015-05-08 00:00:00

abstract：:The proliferation promoting activity of various proteolytic fragments of human plasma fibronectin was assayed. Study of this activity in fragments, purified by affinity chromatography, has shown that only heparin-binding fragments were capable of promoting fibroblast proliferation while gelatin- and fibrin-binding fra...

journal_title：Biochemical and biophysical research communications

authors： Zlatopolsky AD,Chubukina AN,Berman AE

更新日期：1992-03-16 00:00:00

abstract：:It has been suggested that stress stimuli from the microenvironment maintain a subset of tumor cells with stem-like properties, including drug resistance. Here, we investigate whether Sp1, a stress-responsive factor, regulates stemness gene expression and if its inhibition sensitizes cancer cells to chemotherapy. Hydr...

journal_title：Biochemical and biophysical research communications

authors： Chang KY,Huang CT,Hsu TI,Hsu CC,Liu JJ,Chuang CK,Hung JJ,Chang WC,Tsai KK,Chuang JY

更新日期：2017-11-04 00:00:00

abstract：:p47-phox is one of the cytosolic activation factors of NADPH oxidase in neutrophils and known to translocate to plasma membranes and function by protein kinase C-phosphorylation. In cytosol fraction, prepared from calyculin A-treated neutrophils, the activity of cytosolic factor to activate NADPH oxidase was more redu...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Saeki S,Yamane H,Okamura N,Ishibashi S

更新日期：1995-11-02 00:00:00

abstract：:Protein, mRNA and activity levels of the calcium-independent protein kinase C (nPKC) isoenzymes were examined in NG108-15 cells. Western blot analyses reveal that proliferating NG 108-15 cells express the delta, epsilon, and eta, but not the theta species. The atypical species PKC zeta was also detected. Differentiati...

journal_title：Biochemical and biophysical research communications

authors： Battaini F,Pascale A,Lucchi L,Racchi M,Bergamaschi S,Parenti M,Wetsel WC,Govoni S,Trabucchi M

更新日期：1994-09-30 00:00:00

abstract：:High mobility group box 1 (HMGB1) was recently shown to be an important extracellular mediator of severe vascular inflammatory disease, sepsis. Lysozyme (LYZ) has been shown to bind to bacterial lipopolysaccharide (LPS) and have a potential for playing a role in the therapy of inflammatory diseases. However, the effec...

journal_title：Biochemical and biophysical research communications

authors： Lee W,Park EJ,Kwak S,Kim Y,Na DH,Bae JS

更新日期：2015-04-17 00:00:00

abstract：:The effect of inositol 1,4,5-trisphosphate (IP3) on Ca2+ release in the transformed murine mast cells, mastocytoma P-815 cells permeabilized with digitonin was studied. Ca2+ was sequestered by intracellular organelles in the presence of ATP until the medium free Ca2+ concentration was lowered to a new steady-state lev...

journal_title：Biochemical and biophysical research communications

authors： Muto Y,Tohmatsu T,Yoshioka S,Nozawa Y

更新日期：1986-02-26 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds modulate various endocrine functions by enhancing ligand metabolism, altering hormone synthesis, down regulating receptor levels, and interfering with gene transcription. In the present study, we investigated the effects of TCDD on testosterone signal tr...

journal_title：Biochemical and biophysical research communications

authors： Jana NR,Sarkar S,Ishizuka M,Yonemoto J,Tohyama C,Sone H

更新日期：1999-03-24 00:00:00

abstract：:Treatment of newborn murine epidermal cells with phospholipase C results in the generation of a chemiluminescence response similar to that previously described for phorbol ester tumor promoters. Based on inhibitor studies, the oxidant, believed to be superoxide anion, is most likely generated from lipoxygenase metabol...

journal_title：Biochemical and biophysical research communications

authors： Fischer SM,Baldwin JK,Adams LM

更新日期：1985-09-30 00:00:00

abstract：:Recent identification of intracellular proteins that bind ammodytoxin (calmodulin, 14-3-3 proteins, and R25) suggests that this snake venom presynaptically active phospholipase A(2) acts intracellularly. As these ammodytoxin acceptors are cytosolic and mitochondrial proteins, the toxin should be able to enter the cyto...

journal_title：Biochemical and biophysical research communications

authors： Petrovic U,Sribar J,Paris A,Rupnik M,Krzan M,Vardjan N,Gubensek F,Zorec R,Krizaj I

更新日期：2004-11-19 00:00:00

abstract：:Alpha-L-fucosidase was purified from the bull seminal plasma by chromatography on DEAE-disk, octyl sepharose hydrophobic column and HPLC. The enzyme appeared to be pure as judged by the polyacrylamide gel electrophoresis both under the nondenaturing and denaturing conditions. The pure enzyme promoted the acrosome reac...

journal_title：Biochemical and biophysical research communications

authors： Srivastava PN,Arbtan K,Takei GH,Huang TT,Yanagimachi R

更新日期：1986-06-30 00:00:00

abstract：:Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity...

journal_title：Biochemical and biophysical research communications

authors： Humphrey PA,Gangarosa LM,Wong AJ,Archer GE,Lund-Johansen M,Bjerkvig R,Laerum OD,Friedman HS,Bigner DD

更新日期：1991-08-15 00:00:00

abstract：:Chironomus ramosus is known to tolerate high doses of gamma radiation exposure. Larvae of this insect possess more than 95% of hemoglobin (Hb) in its circulatory hemolymph. This is a comparative study to see effect of gamma radiation on Hb of Chironomus and humans, two evolutionarily diverse organisms one having extra...

journal_title：Biochemical and biophysical research communications

authors： Gaikwad PS,Panicker L,Mohole M,Sawant S,Mukhopadhyaya R,Nath BB

更新日期：2016-08-05 00:00:00

abstract：:During autophagy, the microtubule-associated protein light chain 3 (LC3), a specific autophagic marker in mammalian cells, is processed from the cytosolic form (LC3-I) to the membrane-bound form (LC3-II). In HEK293 cells stably expressing FLAG-tagged LC3, activation of protein kinase C inhibited the autophagic process...

journal_title：Biochemical and biophysical research communications

authors： Jiang H,Cheng D,Liu W,Peng J,Feng J

更新日期：2010-05-14 00:00:00