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Heparin-binding fibronectin fragments containing cell-binding domains and devoid of hep2 and gelatin-binding domains promote human embryo fibroblast proliferation.

Abstract：

:The proliferation promoting activity of various proteolytic fragments of human plasma fibronectin was assayed. Study of this activity in fragments, purified by affinity chromatography, has shown that only heparin-binding fragments were capable of promoting fibroblast proliferation while gelatin- and fibrin-binding fragments were not. Heparin-binding fragments with high affinity for heparin were characterized by high activity levels while those with low heparin affinity were inactive. Heparin-binding fragments with the highest proliferation promoting activity contained the cell-binding domain and were virtually devoid of the hep2, hep1 and gelatin-binding domains.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zlatopolsky AD,Chubukina AN,Berman AE

doi

10.1016/0006-291x(92)90492-4

subject

Has Abstract

pub_date

1992-03-16 00:00:00

pages

383-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)90492-4

journal_volume

183

pub_type

杂志文章

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