HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2).

abstract：:A novel human gene containing an ankyrin repeat and BTB/POZ domains (BPOZ) was isolated from a human leukocyte cDNA library. The cDNA sequence contains an open reading frame of 1434 bp that encodes 478 amino acid residues with a predicted molecular mass of 53.9 kDa. Sequence pattern analysis shows that BPOZ contains a...

journal_title：Biochemical and biophysical research communications

authors： Dai KS,Wei W,Liew CC

更新日期：2000-07-14 00:00:00

abstract：:A 5T/6T polymorphism in the human MMP-3 promoter affects gene expression and impacts the risk and/or severity of various pathological conditions. Chromatin immunoprecipitation (ChIP) in human fibroblasts homozygous for the 6T site demonstrate that it is bound by NF-kappaB and ZBP-89 transcription factors in its native...

journal_title：Biochemical and biophysical research communications

authors： Borghaei RC,Gorski G,Javadi M,Mariah Chambers.

更新日期：2009-05-01 00:00:00

abstract：:Nuclear envelope peptides of the rat ventral prostate in the molecular weight region 18,400 to 19,400 show marked androgen dependence. After castration these peptides disappear. Re-administration of testosterone restores them. They were not extracted by 0.1 M NaCl or 5% HClO4 but were partially extracted by 0.35 M NaC...

journal_title：Biochemical and biophysical research communications

authors： Venkatraman JT,Howell GM,Lefebvre YA

更新日期：1984-12-14 00:00:00

abstract：:Nitric oxide synthase (EC 1.14.23) substrate analog inhibitors NG-monomethyl-L-Arg, NG-nitro-L-Arg, NG-nitro-L-Arg methyl ester, and aminoguanidine were examined as potential inhibitors of rat liver arginase (EC 3.5.3.1). NG-nitro-L-Arg was found to inhibit arginase catalyzed conversion of L-Arg to L-Orn at pH 7.5 wit...

journal_title：Biochemical and biophysical research communications

authors： Robertson CA,Green BG,Niedzwiecki L,Harrison RK,Grant SK

更新日期：1993-12-15 00:00:00

abstract：:We cloned a cDNA encoding a novel extracellular signal-regulated kinase (ERK) 2-binding protein, EBITEIN1, by yeast two-hybrid screening. Northern and Western blotting experiments showed that the transcript and protein were expressed in the testes. Furthermore, immunohistochemical experiments showed that EBITEIN1 exis...

journal_title：Biochemical and biophysical research communications

authors： Miura K,Imaki J

更新日期：2008-04-04 00:00:00

abstract：:HIV-1 protease inhibitors are effective in HIV/AIDS therapy, although drug resistance is a severe problem. This study examines the effects of four investigational inhibitors against HIV-1 protease with drug resistant mutations of V32I, I47V and V82I (PRTri) that model the inhibitor-binding site of HIV-2 protease. Thes...

journal_title：Biochemical and biophysical research communications

authors： Pawar S,Wang YF,Wong-Sam A,Agniswamy J,Ghosh AK,Harrison RW,Weber IT

更新日期：2019-06-30 00:00:00

abstract：:The conformations of the neuropeptide galanin in water and trifluoroethanol solutions have been examined by 1H NMR spectroscopy. Analysis of two-dimensional NMR experiments enabled the assignment of virtually all the 1H resonances of galanin in trifluoroethanol solution and many of the 1H resonances in aqueous solutio...

journal_title：Biochemical and biophysical research communications

authors： Wennerberg AB,Cooke RM,Carlquist M,Rigler R,Campbell ID

更新日期：1990-02-14 00:00:00

abstract：:The major bovine seminal plasma protein, PDC-109, binds to choline phospholipids of the sperm plasma membrane and induces an efflux of cholesterol and choline phospholipids (cholesterol efflux), which is crucial for sperm capacitation. PDC-109 also exhibits chaperone-like activity and protects target proteins against ...

journal_title：Biochemical and biophysical research communications

authors： Singh BP,Saha I,Nandi I,Swamy MJ

更新日期：2017-12-02 00:00:00

abstract：:Nitric oxide (NO*) is produced endogenously from NOS isoforms bound to sarcolemmal (SL) and sarcoplasmic reticulum (SR) membranes. To investigate whether locally generated NO* directly affects the activity of enzymes mediating ion active transport, we studied whether knockout of selected NOS isoforms would affect the ...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Burnett AL,Huang PL,Becker LC,Kuppusamy P,Kass DA,Kevin Donahue J,Proud D,Sham JS,Dawson TM,Xu KY

更新日期：2002-06-28 00:00:00

abstract：:The presence and localization of mitochondrial calmodulin was directly proved immuno-electron microscopically by the protein A-gold technique. In the ultra-pure mitochondria the complexes of anti-calmodulin antibody and protein A-gold clearly showed the localization of mitochondrial calmodulin on the inner membrane an...

journal_title：Biochemical and biophysical research communications

authors： Hatase O,Doi A,Itano T,Matsui H,Ohmura Y

更新日期：1985-10-15 00:00:00

abstract：:To elucidate the physiological importance of neuronal (N)-type calcium channels in sympathetic controls, we analyzed N-type channel-deficient (NKO) mice. Immunoprecipitation analysis revealed increased interaction between beta3 (a major accessory subunit of N-type channels) and R-type channel-forming CaV2.3 in NKO mic...

journal_title：Biochemical and biophysical research communications

authors： Murakami M,Ohba T,Wu TW,Fujisawa S,Suzuki T,Takahashi Y,Takahashi E,Watanabe H,Miyoshi I,Ono K,Sasano H,Ito H,Iijima T

更新日期：2007-03-23 00:00:00

abstract：:Loss-of-function mutations in the DJ-1/PARK7 gene are responsible for early-onset autosomal-recessive Parkinson's disease. DJ-1 is implicated in the protection of neurons from oxidative stress by scavenging hydrogen peroxide and regulating the transcriptional activity of multiple pathways. Here, we attempted to identi...

journal_title：Biochemical and biophysical research communications

authors： Kim SJ,Park YJ,Oh YJ

更新日期：2012-05-25 00:00:00

abstract：:The neural stem cell (NSC) niche in subventricular zone (SVZ) of adult mammalian brain contains dense vascular plexus, where endothelial cells (ECs) regulate NSCs by releasing plenty of angiocrine factors. However, the role of ECs-derived exosomes, a novel type of mediators of intercellular communications, in the regu...

journal_title：Biochemical and biophysical research communications

authors： Zhang YZ,Liu F,Song CG,Cao XL,Zhang YF,Wu HN,Guo CJ,Li YQ,Zheng QJ,Zheng MH,Han H

更新日期：2018-01-01 00:00:00

abstract：:An angiogenesis inhibitor named Beta-35 has been identified and purified from the conditioned medium of mouse pancreatic β cells tumor cells. Beta-35 has a molecular weight of 35 kDa and inhibits DNA synthesis of bovine capillary endothelial cells at a half-maximal concentration of approximately 5 nM. It shows anti-an...

journal_title：Biochemical and biophysical research communications

authors： Liang G,Butterfield C,Liang J,Birsner A,Folkman J,Shing Y

更新日期：2011-06-10 00:00:00

abstract：:The enzymatic activity of cystathionine beta synthase has been studied in fibroblasts of nine patients with regular trisomy 21. An excess of CBS activity was found in trisomy 21 with a trisomy 21/normal ratio equal to 1.66. A 1.04 ratio was found in 21q21----21 p ter monosomy; a 1.04 and 0.99 ratio was found in two 21...

journal_title：Biochemical and biophysical research communications

authors： Chadefaux B,Rethoré MO,Raoul O,Ceballos I,Poissonnier M,Gilgenkranz S,Allard D

更新日期：1985-04-16 00:00:00

abstract：:Antisense activity in living cells has been thought to occur via a mechanism involving both DNA-mediated hybridization arrest of target mRNA and RNase H-mediated mRNA digestion. Therefore an ideal antisense agent should be permeable to the cell and possess capacities (1) to form a thermally stable duplex in vivo with ...

journal_title：Biochemical and biophysical research communications

authors： Matsukura M,Okamoto T,Miike T,Sawai H,Shinozuka K

更新日期：2002-05-24 00:00:00

abstract：:Members of the Rab family of low molecular weight GTP-binding (LMWG) proteins regulate vesicular transport; distinct Rab proteins are located in specific vesicular compartments within the exocytotic and endocytotic pathway. Pancreatic zymogen granules possess multiple LMWG. Rab 3A, however, which has been suggested to...

journal_title：Biochemical and biophysical research communications

authors： Wagner AC,Strowski MZ,Göke B,Williams JA

更新日期：1995-02-27 00:00:00

abstract：:Vinculin and meta-vinculin are related proteins that localize to adherens junctions. To facilitate studies on the biology of these proteins cDNA clones were isolated from a chick embryonic library made in lambda gt 11. Three clones, accounting for 1/2 of the vinculin message, were identified by immunological analyses ...

journal_title：Biochemical and biophysical research communications

authors： Coutu MD,Simon DJ,Brown AE,Craig SW

更新日期：1987-09-15 00:00:00

abstract：:The 160 kDa alpha-mannosidase (E.C. 3.2.1.24) isolated from culture filtrate of Trichoderma reesei has wide aglycon specificity but cleaves the alpha1 --> 2 and alpha1 --> 3 mannosidic bonds with higher rate than alpha1 --> 6 bond and slowly hydrolyses yeast mannan and 1,6-alpha-mannan. The specific activity of the en...

journal_title：Biochemical and biophysical research communications

authors： Eneyskaya EV,Kulminskaya AA,Savel'ev AN,Shabalin KA,Golubev AM,Neustroev KN

更新日期：1998-04-07 00:00:00

abstract：:Alpha 1-acid glycoprotein (AGP) complementary DNA clone has been isolated from an acute phase rabbit liver library. Complete and full-length nucleotide sequence of this cDNA has been determined. The cDNA contains 35 nucleotides 5' untranslated region followed by 606 nucleotides of coding region and a 112 nucleotides 3...

journal_title：Biochemical and biophysical research communications

authors： Ray BK,Ray A

更新日期：1991-07-31 00:00:00

abstract：:The carnitine/acylcarnitine carrier from rat liver mitochondria was overexpressed in Escherichia coli. The expressed protein, recovered as inclusion bodies, was solubilized with sarkosyl and purified by Sephadex G-200 and celite chromatography. A yield of 15 mg of purified transport protein per liter of cell culture w...

journal_title：Biochemical and biophysical research communications

authors： Indiveri C,Iacobazzi V,Giangregorio N,Palmieri F

更新日期：1998-08-28 00:00:00

abstract：:Most proteins synthesized in cytoplasm target to mitochondria through sequences at their amino termini. However, a previous study suggests that the native carboxyl terminus of ISP6 might be critical of its specific delivery. Here we investigated the sequence directing ISP6 to yeast mitochondrial outer membrane. Unlike...

journal_title：Biochemical and biophysical research communications

authors： Cao W,Douglas MG

更新日期：1996-07-16 00:00:00

abstract：:The involvement of vitamin D in prostate carcinogenesis was investigated using the human prostatic LNCaP cells. Incubation of the LNCaP with 100 nM 1 alpha,25-dihydroxyvitamin D3 for 2 days resulted in a 30-40% suppression of cell growth, which was accompanied by a greater than 70% down-regulated expression of the pro...

journal_title：Biochemical and biophysical research communications

authors： Hsieh TY,Ng CY,Mallouh C,Tazaki H,Wu JM

更新日期：1996-06-05 00:00:00

abstract：:The morphology and function of Leydig cells are changed during the development, mature and senility of Leydig cells along the life span of males. This study was to observe the growth morphology of adult mouse Leydig cells in culture, aiming to provide a reference for furthermore understanding of the biological functio...

journal_title：Biochemical and biophysical research communications

authors： Wang JQ,Cao WG

更新日期：2016-01-22 00:00:00

abstract：:Signal transduction by transforming growth factor-beta (TGF-beta) involves the formation of a heteromeric complex of two transmembrane serine/threonine kinase receptors, type I (T beta R-I) and type II (T beta R-II). In the region preceeding the kinase domain of T beta R-I there is a glycine- and serine-rich sequence,...

journal_title：Biochemical and biophysical research communications

authors： Franzén P,Heldin CH,Miyazono K

更新日期：1995-02-15 00:00:00

abstract：:[3H]cyclo(His-Pro) bound with high affinity (59 nM) to a single class of sites in rat liver plasma membranes, without significant tracer degradation during equilibration for 60 min at 0 degrees C. Binding was specific and saturable (3.9 pmol/mg protein), and were increased by the addition of K+, Mg++ and Na+ at optima...

journal_title：Biochemical and biophysical research communications

authors： Mori M,Yamada M,Yamaguchi M,Suzuki M,Ohshima K,Kobayashi I,Kobayashi S

更新日期：1986-01-14 00:00:00

abstract：:Lysates of rabbit reticulocytes and other mammalian cells are known to contain an activity which binds with high specificity ppp(A2'p)3A,3'-[32P]pCp. The binding activity shows a marked dependence on preincubation of lysates at different temperatures (4 degrees C - 45 degrees C). For example, binding was increased 50%...

journal_title：Biochemical and biophysical research communications

authors： Wu JM,Eslami B,Semproni AR

更新日期：1983-11-30 00:00:00

abstract：:Constitutive and PKC-regulated alpha-secretase pathways have been reported to produce the secreted form of alpha-secretase-derived APP (sAPPalpha). Here, we examined putative role of furin in the regulation of alpha-secretase activity in vitro and in vivo. Overexpression of the prodomain of furin and infection with a ...

journal_title：Biochemical and biophysical research communications

authors： Hwang EM,Kim SK,Sohn JH,Lee JY,Kim Y,Kim YS,Mook-Jung I

更新日期：2006-10-20 00:00:00

abstract：:In order to characterize the direct involvement of cAMP in the change of osteoblast proliferation by parathyroid hormone (PTH), we employed the diastereoisomers of adenosine 3',5'-cyclic phosphorothioate, Sp-cAMPS and Rp-cAMPS, which have been recently shown to act directly as agonist and antagonist, respectively in t...

journal_title：Biochemical and biophysical research communications

authors： Kano J,Sugimoto T,Fukase M,Fujita T

更新日期：1991-05-31 00:00:00

abstract：:Aerobic incubation of rat spermatozoa in a balanced salt solution containing 10 microM of gossypol produced a loss of sperm motility. This effect was not reverted by the presence of 25 mM Theophylline, a well-known stimulant of motility, but was significantly diminished by the addition of 10 mM Mannitol. As mannitol i...

journal_title：Biochemical and biophysical research communications

authors： Fornés MW,Barbieri AM,Burgos MH

更新日期：1993-09-30 00:00:00