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Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production.

Abstract：

:Aerobic incubation of rat spermatozoa in a balanced salt solution containing 10 microM of gossypol produced a loss of sperm motility. This effect was not reverted by the presence of 25 mM Theophylline, a well-known stimulant of motility, but was significantly diminished by the addition of 10 mM Mannitol. As mannitol is a superoxide scavenger and we found a close correlation between the loss of sperm motility and the malondialdehyde production, we concluded that gossypol affect rat spermatozoa by producing a peroxidative breakdown of membrane phospholipids.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fornés MW,Barbieri AM,Burgos MH

doi

10.1006/bbrc.1993.2183

subject

Has Abstract

pub_date

1993-09-30 00:00:00

pages

1289-93

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72183-2

journal_volume

195

pub_type

杂志文章

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