当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > EEN regulates the proliferation and survival of multiple myeloma cells by potentiating IGF-1 secretion.

EEN regulates the proliferation and survival of multiple myeloma cells by potentiating IGF-1 secretion.

Abstract：

:The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferation, EEN accelerated cell proliferation, facilitated cell cycle transition from G1 to S phase by regulating cyclin-dependent kinases (CDKs) pathway, and delayed cell apoptosis via Bcl2/Bax-mitochondrial pathway. Mechanistically, we found that EEN was indispensable for insulin-like growth factor-1 (IGF-1) secretion and the activation of protein kinase B-mammalian target of rapamycin (Akt-mTOR) pathway. Exogenous IGF-1 overcame the phenotype of EEN depletion, while IGF-1 neutralization overcame that of EEN over-expression. Collectively, these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma. Therefore, EEN may represent a potential diagnostic marker or therapeutic target for multiple myeloma.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Huang EW,Xue SJ,Li XY,Xu SW,Cheng JD,Zheng JX,Shi H,Lv GL,Li ZG,Li Y,Liu CH,Chen XH,Liu H,Li J,Liu C

doi

10.1016/j.bbrc.2014.03.127

subject

Has Abstract

pub_date

2014-05-02 00:00:00

pages

271-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)00587-7

journal_volume

447

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Differential regulation of IGF-II-induced IL-8 by extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinases in human keratinocytes.

    abstract：:In order to study the relationship between insulin like growth factor-II (IGF-II) and interleukin-8 (IL-8) that are upregulated in psoriasis, we monitored IL-8 expression in IGF-II-treated human keratinocytes and explored the signaling pathways of IL-8 expression by IGF-II. IGF-II increased the IL-8 mRNA and protein l...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.042

    authors： Kim HJ,Byun SJ,Kim TY

    更新日期：2004-04-23 00:00:00

  • Kaiso is a key regulator of spleen germinal center formation by repressing Bcl6 expression in splenocytes.

    abstract：:Kaiso was previously described as a methylated DNA-binding protein and a transcription repressor interacting with the corepressor protein complex NCoR. In the current study, we show that generation-3 Kaiso knockout mice show a phenotype of splenomegaly and large diffused germinal centers (GC). In the spleens of Kaiso ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.11.046

    authors： Koh DI,Yoon JH,Kim MK,An H,Kim MY,Hur MW

    更新日期：2013-12-13 00:00:00

  • Molecular size of the Na+-H+ antiport in renal brush border membranes, as estimated by radiation inactivation.

    abstract：:The radiation inactivation method was applied to brush border membrane vesicles from rat kidney, in order to estimate the molecular size of the Na+-H+ antiporter. Sodium influx (1mM) driven by an acid intravesicular pH was unaffected by the high osmolarity of the cryoprotective solution. Initial rate of influx was est...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80739-3

    authors： Béliveau R,Demeule M,Potier M

    更新日期：1988-04-15 00:00:00

  • New insights into the posttranslational regulation of human cytosolic thioredoxin by S-palmitoylation.

    abstract：:High level of palmitate is associated with metabolic disorders. We recently showed that enhanced level of S-palmitoylated cytosolic thioredoxin (Trx1) in mouse liver was new characteristic feature of insulin resistance. However, our understanding of the effect of S-palmitoylation on Trx1 is limited, and the tissue spe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.03.132

    authors： Xu Z,Zhong L

    更新日期：2015-05-15 00:00:00

  • Microglia express a functional receptor for interleukin-23.

    abstract：:Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor beta1 (IL-12Rbeta1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells. A recen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.059

    authors： Sonobe Y,Liang J,Jin S,Zhang G,Takeuchi H,Mizuno T,Suzumura A

    更新日期：2008-05-23 00:00:00

  • DSCAM: an endogenous promoter drives expression in the developing CNS and neural crest.

    abstract：:The development of central nervous system (CNS) neuronal networks involves processes including neuroblast migration, axonal pathfinding, and synaptogenesis. To evaluate the role of the axonal guidance molecule DSCAM in CNS connectivity, we generated a lacZ reporter construct, Pr1.8-betagal, containing a 1.8kb fragment...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02548-2

    authors： Barlow GM,Lyons GE,Richardson JA,Sarnat HB,Korenberg JR

    更新日期：2002-11-22 00:00:00

  • Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties.

    abstract：:Various methods have been used to evaluate anti-fibrotic activity of drugs. However, most of them are complicated, labor-intensive and lack of efficiency. This study was intended to develop a rapid method for anti-fibrotic drugs screening based on biophysical properties. A549 cells in vitro were stimulated with transf...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.10.127

    authors： Liu M,Zheng M,Xu H,Liu L,Li Y,Xiao W,Li J,Ma E

    更新日期：2015-12-04 00:00:00

  • Diethanolamine inhibits choline uptake and phosphatidylcholine synthesis in Chinese hamster ovary cells.

    abstract：:Diethanolamine (DEA), an alkanolamine used widely in industry, is hepatocarcinogenic in mice. The goal of this work was to determine whether DEA altered choline homeostasis in cultured cells, so as to ascertain whether the liver tumor response may be related to choline deficiency. CHO cells were cultured in Ham's F-12...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1253

    authors： Lehman-McKeeman LD,Gamsky EA

    更新日期：1999-09-07 00:00:00

  • Cell death pathology: perspective for human diseases.

    abstract：:Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregul...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2011.09.081

    authors： Agostini M,Tucci P,Melino G

    更新日期：2011-10-28 00:00:00

  • N-methyl-N-nitrosourea evidences cell cycle associated transient sequences in hepatic replicating DNA.

    abstract：:Experiments of molecular hybridization were carried out with the aim of singling out DNA sequences which might be important in the hepatocarcinogenic action of N-methyl-N-nitrosourea. Results were obtained suggesting the synthesis of transitory DNA sequences during compensatory cell proliferation. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1367

    authors： Kanduc D

    更新日期：1995-03-17 00:00:00

  • Lipopolysaccharide prevents apoptosis induced by brefeldin A, an endoplasmic reticulum stress agent, in RAW 264.7 cells.

    abstract：:The effect of lipopolysaccharide (LPS) on the cell death induced by endoplasmic reticulum (ER) stress agents in RAW 264.7 cells was studied. LPS prevented the cell death by brefeldin A, but not thapsigargin and tunicamycin. CpG DNA as well as LPS prevented brefeldin A-induced cell death whereas tumor necrosis factor-a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.050

    authors： Islam S,Hassan F,Tumurkhuu G,Ito H,Koide N,Mori I,Yoshida T,Yokochi T

    更新日期：2006-02-10 00:00:00

  • Apoptosis induced by BIK was decreased with RNA interference of caspase-12.

    abstract：:BIK, a member of the Bcl-2 family, has been reported to induce cell apoptosis but the underlying mechanisms are not well delineated. We used siRNA targeting caspase-12 to examine the effect of caspase-12 on apoptosis induced by BIK. In this study, we show that caspase-12 was activated by BIK. With caspase-12 knocked d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.175

    authors： Zhao X,Sun Y,Yu H,Ye L,Zhang L,Lu J,Yuan Y,Qian G,Ge S

    更新日期：2007-08-10 00:00:00

  • Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.

    abstract：:Somatostatin exerts diverse effects in various tissues upon binding its specific membrane receptors. Recently, we have cloned three different somatostatin receptor subtypes. Here we report the sequence and functional expression of a fourth and a fifth human somatostatin receptor subtype, termed hSSTR4 and hSSTR5, resp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2122

    authors： Yamada Y,Kagimoto S,Kubota A,Yasuda K,Masuda K,Someya Y,Ihara Y,Li Q,Imura H,Seino S

    更新日期：1993-09-15 00:00:00

  • Isolation of a human liver ligandin cDNA clone and demonstration of sequence homology at ligandin loci in rats and humans.

    abstract：:Using a monospecific antibody to the major cytosolic glutathione-S-transferase of human liver, we have isolated a cDNA clone from a human liver cDNA expression vector library in lambda gt11. The clone cross-hybridizes with a rat liver ligandin (glutathione-S-transferase 1-2) cDNA probe. The clone has an insert of 1.25...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91511-7

    authors： Butera L,Monnier JR,Campbell E,Bhargava MM

    更新日期：1987-02-13 00:00:00

  • Multiplex standardized RT-PCR for expression analysis of many genes in small samples.

    abstract：:Standardized RT-PCR (StaRT-PCR) enables numerical quantification as well as intra- and inter-laboratory comparison of gene expression. Multiplex StaRT-PCR, using two rounds of amplification, was conducted on Stratagene Universal Reference RNA. In the first round, cDNA, competitive template (CT) mix, and primers for up...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00243-7

    authors： Crawford EL,Warner KA,Khuder SA,Zahorchak RJ,Willey JC

    更新日期：2002-04-26 00:00:00

  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization.

    abstract：:Ras proteins can be modified at their COOH-terminal cysteine in the motif Cys-Ali-Ali-Xaa by a farnesyl isoprenoid. This modification is essential for membrane association and biological activity of ras proteins. A similar COOH-terminal amino acid sequence, Cys-Xaa-Ali-Xaa, exists in the ras-related GTP-binding protei...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91217-g

    authors： Didsbury JR,Uhing RJ,Snyderman R

    更新日期：1990-09-14 00:00:00

  • Identification of a human immunodeficiency virus-1 protease cleavage site within the 66,000 Dalton subunit of reverse transcriptase.

    abstract：:The human immunodeficiency virus-1 reverse transcriptase is a heterodimer of related 51 and 66 kDa subunits. The smaller subunit arises by viral protease-catalyzed cleavage of the carboxy-terminal domain of the 66 kDa species. Comparison of the amino acid composition analyses of the isolated 51 kDa and 66 kDa subunits...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91670-n

    authors： Graves MC,Meidel MC,Pan YC,Manneberg M,Lahm HW,Grüninger-Leitch F

    更新日期：1990-04-16 00:00:00

  • Occurrence of sex steroid hormones and their binding proteins in Octopus vulgaris lam.

    abstract：:The present study reports the presence of progesterone, testosterone and 17 beta-estradiol and their corresponding binding proteins in the reproductive system of Octopus vulgaris Lam (phylum Mollusca, subphylum Cephalopoda). These sex hormones occur in testis, vas deferens, seminal vesicle, prostate and Needham's sac....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1585

    authors： D'Aniello A,Di Cosmo A,Di Cristo C,Assisi L,Botte V,Di Fiore MM

    更新日期：1996-10-23 00:00:00

  • MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells.

    abstract：:Lung cancer causes high mortality without a declining trend and non small cell lung cancer represents 85% of all pulmonary carcinomas. MicroRNAs (miRNAs) serve as fine regulators of proliferation, migration, invasion/metastasis and angiogenesis of normal and cancer cells. Using TargetScan6.2, we predicted that the ubi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.04.025

    authors： Savita U,Karunagaran D

    更新日期：2013-05-17 00:00:00

  • A salt bridge between an N-terminal coiled coil of gp41 and an antiviral agent targeted to the gp41 core is important for anti-HIV-1 activity.

    abstract：:HIV-1 envelope glycoprotein transmembrane subunit gp41 play a critical role in the fusion of viral and target cell membranes. The gp41 C-terminal heptad repeat region interacts with the N-terminal coiled-coil region to form a six-stranded core structure. Peptides derived from gp41 C-terminal heptad repeat region (C-pe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2411

    authors： Jiang S,Debnath AK

    更新日期：2000-04-02 00:00:00

  • Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells.

    abstract：:Glypican 3 (GPC3), a GPI-anchored heparan sulfate proteoglycan, is expressed in the majority of hepatocellular carcinoma (HCC) tissues. Using MRL/lpr mice, we successfully generated a series of anti-GPC3 monoclonal antibodies (mAbs). GPC3 was partially cleaved between Arg358 and Ser359, generating a C-terminal 30-kDa ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.11.033

    authors： Nakano K,Orita T,Nezu J,Yoshino T,Ohizumi I,Sugimoto M,Furugaki K,Kinoshita Y,Ishiguro T,Hamakubo T,Kodama T,Aburatani H,Yamada-Okabe H,Tsuchiya M

    更新日期：2009-01-09 00:00:00

  • Caenorhabditis elegans development requires mitochondrial function in the nervous system.

    abstract：:The mitochondrial respiratory chain (MRC) supplies the majority of the energy requirements of most eucaryotic cells. A null mutation in the Caenorhabditis elegans nuo-1 gene encoding a subunit of complex I (NADH-ubiquinone oxidoreductase) is lethal, leading to a developmental arrest at the third larval stage. To ident...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.108

    authors： Ndegwa S,Lemire BD

    更新日期：2004-07-09 00:00:00

  • Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation.

    abstract：:Interleukin (IL)-33, an IL-1 family member, acts as an extracellular cytokine by binding its cognate receptor, ST2. IL-33 is also a chromatin-binding transcriptional regulator highly expressed in the nuclei of endothelial cells. However, the function of IL-33 as a nuclear factor is poorly defined. Here, we show that I...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.04.005

    authors： Choi YS,Park JA,Kim J,Rho SS,Park H,Kim YM,Kwon YG

    更新日期：2012-05-04 00:00:00

  • An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding.

    abstract：:Expression of the MHC class I chain related molecules A and B (MICA/B) on tumor cell surface can signal the immune receptor NKG2D for tumor immune destruction. However, MIC was found to be shed by tumors in cancer patients, which negatively regulates host immunity and promotes tumor immune evasion and progression. The...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.07.062

    authors： Wang X,Lundgren AD,Singh P,Goodlett DR,Plymate SR,Wu JD

    更新日期：2009-09-25 00:00:00

  • TFDP3 inhibits E2F1-induced, p53-mediated apoptosis.

    abstract：:By dimerizing with E2F proteins, TFDP has profound influence on cellular E2F activities. While TFDP1 and 2 enhance the DNA binding and the transcriptional activity of E2F, the newly identified member of the DP family, TFDP3 primarily functions as a negative regulator. To further characterize the inhibitory property of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.06.128

    authors： Tian C,Lv D,Qiao H,Zhang J,Yin YH,Qian XP,Wang YP,Zhang Y,Chen WF

    更新日期：2007-09-14 00:00:00

  • Eukaryotic initiation factor 4B from wheat and Arabidopsis thaliana is a member of a multigene family.

    abstract：:Clones of eukaryotic initiation factor (eIF) 4B from wheat and Arabidopsis thaliana were obtained from cDNA and genomic libraries. The exon/intron organization of the genes from wheat and A. thaliana is very similar. The deduced amino acid sequences for the wheat and Arabidopsis eIF4B proteins showed overall similarit...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1814

    authors： Metz AM,Wong KC,Malmström SA,Browning KS

    更新日期：1999-12-20 00:00:00

  • Protein synthesis in rabbit reticulocytes: requirements for Met-tRNAf . 40S preinitiation complex formation with AUG-codon and physiological mRNAs.

    abstract：:Under standard conditions, in the presence of GTP, highly purified eIF-2 and Co-eIF-2 factor preparations efficiently stimulated AUG-codon dependent but not physiological mRNA-dependent Met-tRNAf binding to 40S ribosomes. Replacement of GTP by a nonhydrolyzable GTP analog, GMP-PNP, in the above system, gave significan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91249-x

    authors： Roy R,Nasrin N,Ahmad MF,Gupta NK

    更新日期：1984-08-16 00:00:00

  • Essential role of nitric oxide in descending inhibition in the rat proximal colon.

    abstract：:Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91605-r

    authors： Hata F,Ishii T,Kanada A,Yamano N,Kataoka T,Takeuchi T,Yagasaki O

    更新日期：1990-11-15 00:00:00

  • Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase.

    abstract：:The level of cis-prenyl transferase activity has been implicated in controlling the level of biosynthesis of dolichol and dolichol intermediates. In this study, we isolated a cDNA encoding a human CPT (GenBank Accession No. ), which had substantial homology to other CPT isolated from human brain, bacteria, Arabidopsis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.03.181

    authors： Jones J,Viswanathan K,Krag SS,Betenbaugh MJ

    更新日期：2005-06-03 00:00:00

  • Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.

    abstract：:Type I diabetes is a complex disease in which multiple susceptibility loci have been implicated by whole genome scans. IDDM8, a susceptibility locus, is located on chromosome 6q27, however the specific susceptibility gene has yet to be identified. We have examined five potential candidate genes using 36 genetic marker...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.159

    authors： Owerbach D,Piña L,Gabbay KH

    更新日期：2004-10-22 00:00:00