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Angiogenic effects of dual gene transfer of bFGF and PDGF-BB after myocardial infarction.

Abstract：

:Therapeutic effects of combination of angiogenic growth factors for the treatment of ischemia after myocardial infarction are largely unknown. Plasmids expressing basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF-BB) or their combination with a 1:1 mass ratio were injected into hearts with 7-day-old myocardial infarction. Hearts were harvested after 1 and 4 weeks after gene transfer. The major findings in this chronic myocardial infarction model were that bFGF, PDGF-BB and their combination all had a more pronounced angiogenic effect on the arteriolar than the capillary level. bFGF stimulated both capillary and arteriolar growth while PDGF-BB preferentially stimulated arterioles. The combination increased the amount of both capillaries and arterioles and in addition gave rise to stable capillaries compared to single factor transfer but did not further enhance angiogenesis. No cardiovascular side effects were observed after gene transfer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hao X,Månsson-Broberg A,Gustafsson T,Grinnemo KH,Blomberg P,Siddiqui AJ,Wärdell E,Sylvén C

doi

10.1016/j.bbrc.2004.01.165

subject

Has Abstract

pub_date

2004-03-19 00:00:00

pages

1058-63

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X04002311

journal_volume

315

pub_type

杂志文章

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