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High chondroitin sulfate proteoglycan 4 expression correlates with poor outcome in patients with breast cancer.

Abstract：

:Chondroitin sulfate proteoglycan 4 (CSPG4), a transmembrane proteoglycan originally identified in melanoma cells, has been reported to be expressed in breast cancer cells. This study was performed to examine the expression and significance of CSPG4 in a cohort of breast cancer patients. Immunohistochemical analysis of CSPG4 was performed on tissue microarrays constructed from tissue specimens from 240 breast cancer patients. CSPG4 staining was correlated with clinical and pathological characteristics, overall survival (OS), and disease recurrence. Contradicting to a previous report, our results showed that high CSPG4 expression was not related to triple-negative status of breast cancer patients. The Kaplan-Meier method showed that high CSPG4 expression was significantly associated with shorter time to recurrence (TTR). Patients with high CSPG4 expression had poorer OS and shorter TTR in a multivariate survival analysis after adjustment for stage, tumor grade, expression of estrogen receptor and progesterone receptor, and HER2 overexpression. This study showed that high CSPG4 expression correlates with disease recurrence and OS in breast cancers.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hsu NC,Nien PY,Yokoyama KK,Chu PY,Hou MF

doi

10.1016/j.bbrc.2013.10.093

subject

Has Abstract

pub_date

2013-11-15 00:00:00

pages

514-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)01774-9

journal_volume

441

pub_type

杂志文章

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