A new synthetic hypoglycaemic polysaccharide.

abstract：:Fluorogenic substrates for endopeptidases are often prepared by attaching fluorophores and quenchers to opposite ends of the peptide substrates. Here, we describe a new approach by incorporating tryptophan and p-nitrophenylalanine into peptides to give fluorogenic substrates composed entirely of alpha-amino acids. Two...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Liang TC

更新日期：1994-06-15 00:00:00

abstract：:We have previously provided evidence for a mechanism by which acyl DHAP is converted enzymatically to O-alkyl DHAP. This mechanism involves, in part, the formation of an endiol of acyl DHAP, loss of the fatty acid by splitting of the DHAP carbon-1 to oxygen bond and the gain of a long chain fatty alcohol. It has been ...

journal_title：Biochemical and biophysical research communications

authors： Friedberg SJ,Weintraub ST,Peterson D,Satsangi N

更新日期：1987-06-30 00:00:00

abstract：:ZMYND11 (zinc finger MYND-type containing 11) has been widely regarded to be involved in a variety of cancers as a potential suppressor. However, the biological role and mechanism of ZMYND11 in glioblastoma multiform (GBM) remain unknown. In this study, we found that ZMYND11 expression was remarkably decreased in GBM ...

journal_title：Biochemical and biophysical research communications

authors： Yang JP,Yang JK,Li C,Cui ZQ,Liu HJ,Sun XF,Geng SM,Lu SK,Song J,Guo CY,Jiao BH

更新日期：2017-12-16 00:00:00

abstract：:To analyse the species of genes expressed in a cleavage stage mouse embryo, we have constructed a cDNA library containing 3.0 x 10(5) independent clones from about 2 x 10(3) embryos at the 8-cell stage of development. Endo A cDNA prepared from parietal yolk sac endoderm like PYS-2 cells was used to screen the library....

journal_title：Biochemical and biophysical research communications

authors： Nozaki M,Murata K,Morita T,Matsushiro A

更新日期：1988-08-15 00:00:00

abstract：:Wound healing in ligaments is a complex process which leads to functionally impaired scar tissue, even after extended time postinjury. To investigate the potential role of proteinases and inhibitors, as well as potential regulators of their expression, mRNA levels for collagenase, stromelysin, urokinase, PAI-1, and TI...

journal_title：Biochemical and biophysical research communications

authors： Reno C,Boykiw R,Martinez ML,Hart DA

更新日期：1998-11-27 00:00:00

abstract：:Electroporation is the most widely employed method of gene transfer into macrophages which are hard to transfect. RAW 264.7 is a widely used cell line for studying macrophage responses. Electroporation of RAW 264.7 cells with commercial reagents although very efficient is expensive necessitating the development of cos...

journal_title：Biochemical and biophysical research communications

authors： Alamuru-Yellapragada NP,Kapadia B,Parsa KVL

更新日期：2017-05-27 00:00:00

abstract：:The present study has focused on the role of the 42- and 44-kDa mitogen-activated protein kinases (p42/44 MAPKs) and the 38-kDa mitogen-activated protein kinase (p38 MAPK) in the proliferation of the pancreatic beta-cell line MIN6. MIN6 beta-cell proliferation was assessed by measuring 5-bromo-2'-deoxyuridine (BrdU) i...

journal_title：Biochemical and biophysical research communications

authors： Burns CJ,Squires PE,Persaud SJ

更新日期：2000-02-16 00:00:00

abstract：:Effects of the imidazoline compound RX871024 on cytosolic free Ca(2+) concentration ([Ca(2+)]i) and insulin secretion in pancreatic beta-cells from SUR1 deficient mice have been studied. In beta-cells from wild-type mice RX871024 increased [Ca(2+)]i by blocking ATP-dependent K(+)-current (K(ATP)) and inducing membrane...

journal_title：Biochemical and biophysical research communications

authors： Efanov AM,Høy M,Bränström R,Zaitsev SV,Magnuson MA,Efendic S,Gromada J,Berggren PO

更新日期：2001-06-22 00:00:00

abstract：:The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells and induces diff...

journal_title：Biochemical and biophysical research communications

authors： McNamara MJ,Schmitt JD,Wykle RL,Daniel LW

更新日期：1984-07-31 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. Changes in AMPK activity contribute to the regulation of insulin secretion. Epidemiological evidence links the ingestion of saturated fatty acid with hyperinsulinemia. The aim of the present study was to examine the effects of ...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Zhou L,Li G,Luo T,Gu Y,Qian L,Fu X,Li F,Li J,Luo M

更新日期：2007-01-12 00:00:00

abstract：:Macroautophagy (autophagy) is an intracellular catalytic process. We examined the effect of running exercise, which stimulates cardiac work physiologically, on the expression of microtubule-associated protein 1 light chain 3 (LC3)-II, an indicator of autophagy, as well as some autophagy-related proteins in rat cardiac...

journal_title：Biochemical and biophysical research communications

authors： Ogura Y,Iemitsu M,Naito H,Kakigi R,Kakehashi C,Maeda S,Akema T

更新日期：2011-11-04 00:00:00

abstract：:We prepared a specific antibody against GIRK1, the major subunit of the G protein-gated K+ (KG) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in the presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activatio...

journal_title：Biochemical and biophysical research communications

authors： Morishige KI,Inanobe A,Takahashi N,Yoshimoto Y,Kurachi H,Miyake A,Tokunaga Y,Maeda T,Kurachi Y

更新日期：1996-03-18 00:00:00

abstract：:The increasingly appreciated role of astrocytes in neurophysiology dictates a thorough understanding of the mechanisms underlying the communication between astrocytes and neurons. In particular, the uptake and release of signaling substances into/from astrocytes is considered as crucial. The release of different gliot...

journal_title：Biochemical and biophysical research communications

authors： Potokar M,Kreft M,Lee SY,Takano H,Haydon PG,Zorec R

更新日期：2009-12-25 00:00:00

abstract：:Insulin secretion from pancreatic beta cells is partly regulated by cell membrane potential. Background K+ channels that stabilize the resting membrane potential would suppress excitability and insulin secretion. Recent studies show that members of the two-pore domain K+ (K2P) channel family behave as background K+ ch...

journal_title：Biochemical and biophysical research communications

authors： Kang D,Choe C,Kim D

更新日期：2004-10-08 00:00:00

abstract：:Strong temperature dependent low angle X-ray scattering by trifluoroethanol- and hexafluoro-2-propanol-water mixtures was observed in conditions commonly used in NMR work on peptides. At least two types of molecular effects may contribute to the observed scattering: formation of clathrate hydrate-like aggregates of al...

journal_title：Biochemical and biophysical research communications

authors： Kuprin S,Gräslund A,Ehrenberg A,Koch MH

更新日期：1995-12-26 00:00:00

abstract：:Laminins, the major basement membrane glycoproteins, are composed of three subunits. We identified a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. A heptapeptide sequence, MDCPTIS, was inserted close to the two cysteine residues possibly involved in the intersubunit dis...

journal_title：Biochemical and biophysical research communications

authors： Hayashi Y,Kim KH,Fujiwara H,Shimono C,Yamashita M,Sanzen N,Futaki S,Sekiguchi K

更新日期：2002-12-06 00:00:00

abstract：:Phosphorylation of HMG 14 proteins from calf thymus and avian erythrocytes was studied using a cyclic GMP-dependent protein kinase from bovine lung. HMG 14 from calf thymus was a good substrate for the enzyme, but HMG 14 from avian erythrocytes was not phosphorylated. Of the potential phosphorylation sites, the one in...

journal_title：Biochemical and biophysical research communications

authors： Palvimo J,Linnala-Kankkunen A,Mäenpää PH

更新日期：1983-01-27 00:00:00

abstract：:Familial exudative vitreoretinopathy (FEVR) is a congenital hereditary, bilateral eye disorder which affects both retina and the vitreous body. As a first step toward the identification of the gene responsible for the X-linked disorder, we report here the results of DNA analyses from the patients and their parents of ...

journal_title：Biochemical and biophysical research communications

authors： Shastry BS,Trese MT

更新日期：1993-06-15 00:00:00

abstract：:MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. During a search of GenBank EST database, we found a new member of MutT-related protein, MTH2, which possesses the 23-amino...

journal_title：Biochemical and biophysical research communications

authors： Cai JP,Ishibashi T,Takagi Y,Hayakawa H,Sekiguchi M

更新日期：2003-06-13 00:00:00

abstract：:In our previous paper, we reported that a monoclonal antibody (MAb) 710F, which recognizes a cell surface glycoprotein, induces morphological change in monocytic cells, promoting cellular adhesion and extensive spreading on tissue culture dishes [Koyama et al., Biochem, Biophys. Res. Commun., 168 (1990) 898-904]. We r...

journal_title：Biochemical and biophysical research communications

authors： Koyama Y,Suzuki M,Yoshida T

更新日期：1998-05-29 00:00:00

abstract：:Myeloid leukemia factors (MLF1 and MLF2) are proteins associated with leukemia and several other cancers. However, little is known about the regulatory mechanisms underlying the stability of these proteins. Here, we show that DDB1 and CUL4 associated factor 8 (DCAF8), which can form a functional E3 ligase complex (CRL...

journal_title：Biochemical and biophysical research communications

authors： Huang D,Liu C,Sun X,Sun X,Qu Y,Tang Y,Li G,Tong T

更新日期：2020-08-20 00:00:00

abstract：:Based on pseudo amino acid (PseAA) composition and a novel hybrid feature selection frame, this paper presents a computational system to predict the PPIs (protein-protein interactions) using 8796 protein pairs. These pairs are coded by PseAA composition, resulting in 114 features. A hybrid feature selection system, mR...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Cai Y,Lu W,Feng K,Peng C,Niu B

更新日期：2009-03-06 00:00:00

abstract：:A heat-stable protein with antimicrobial activity was isolated from Arabidopsis thaliana plants by buffer-soluble extraction and two chromatographic procedures. The results of MALDI-TOF analysis revealed that the isolated protein shares high sequence identity with aspen SP1. To determine the exact antimicrobial proper...

journal_title：Biochemical and biophysical research communications

authors： Park SC,Lee JR,Shin SO,Park Y,Lee SY,Hahm KS

更新日期：2007-10-26 00:00:00

abstract：:A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these drugs inhibit the enzyme farnesyl pyrophosphate synthase and deplete cells of larger isoprenoids. Inhibition of this enzyme results in impaired processing of both farnesylated and geranylger...

journal_title：Biochemical and biophysical research communications

authors： Wiemer AJ,Tong H,Swanson KM,Hohl RJ

更新日期：2007-02-23 00:00:00

abstract：:Since we recently reported that high density lipoprotein, which contains the bioactive lipid sphingosine-1-phosphate (S1P) [Arterioscler. Thromb. Vasc. Biol. 23 (2003) 802], induced human coronary artery endothelial cell (HCEC) tube formation mediated by a Ras/Raf/ERK (extracellular signal-activated kinase) pathway, w...

journal_title：Biochemical and biophysical research communications

authors： Miura S,Tanigawa H,Matsuo Y,Fujino M,Kawamura A,Saku K

更新日期：2003-07-11 00:00:00

abstract：:In this report we demonstrate formation of a triplex structure by an antiparallel RNA oligonucleotide corresponding to the 21 bp polypurine-pyrimidine stretch from -141 to -162 of the rat alpha 1(I) procollagen promoter with a Kd of 0.1-0.2 microM. The formation of triplexes by the triplex forming oligoribonucleotide ...

journal_title：Biochemical and biophysical research communications

authors： Ririe SS,Guntaka RV

更新日期：1998-08-10 00:00:00

abstract：:Glycogen phosphorylase in PC12 cells exists in two forms analogous to those found in brain and muscle. The active phosphorylated form of the enzyme, phosphorylase-a, represents about 20-30% of total glycogen phosphorylase in these cells. Incubation of PC12 cells with 100 ng 7S nerve growth factor/ml increased phosphor...

journal_title：Biochemical and biophysical research communications

authors： Davis LH,Kauffman FC

更新日期：1986-07-31 00:00:00

abstract：:Rab5 is a GTP-binding protein that is crucial for endocytic machinery functions. We previously identified L-plastin as a binding protein for Rab5, using an affinity column with constitutively active Rab5. L- and T-plastin are isoforms of a plastin protein family belonging to actin-bundling proteins that are implicated...

journal_title：Biochemical and biophysical research communications

authors： Hagiwara M,Shinomiya H,Kashihara M,Kobayashi K,Tadokoro T,Yamamoto Y

更新日期：2011-04-15 00:00:00

abstract：:Expression of macrophage paraoxonase 2 (PON2), a cellular lactonase with anti-oxidant and anti-atherogenic properties, was shown to be upregulated under high oxidative stress. The aim of the present study was to analyze the relationship between the extent of cellular oxidative stress in J774A.1 macrophage and PON2 lac...

journal_title：Biochemical and biophysical research communications

authors： Shiner M,Fuhrman B,Aviram M

更新日期：2006-10-27 00:00:00

abstract：:It has been suggested that stress stimuli from the microenvironment maintain a subset of tumor cells with stem-like properties, including drug resistance. Here, we investigate whether Sp1, a stress-responsive factor, regulates stemness gene expression and if its inhibition sensitizes cancer cells to chemotherapy. Hydr...

journal_title：Biochemical and biophysical research communications

authors： Chang KY,Huang CT,Hsu TI,Hsu CC,Liu JJ,Chuang CK,Hung JJ,Chang WC,Tsai KK,Chuang JY

更新日期：2017-11-04 00:00:00