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G protein-gated K+ channel (GIRK1) protein is expressed presynaptically in the paraventricular nucleus of the hypothalamus.

Abstract：

:We prepared a specific antibody against GIRK1, the major subunit of the G protein-gated K+ (KG) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in the presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activation of the KG channel may underlie presynaptic inhibition of neurotransmitter release by various agonists, such as dopamine, noradrenaline, opioids, and histamine, in PVN.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Morishige KI,Inanobe A,Takahashi N,Yoshimoto Y,Kurachi H,Miyake A,Tokunaga Y,Maeda T,Kurachi Y

doi

10.1006/bbrc.1996.0400

subject

Has Abstract

pub_date

1996-03-18 00:00:00

pages

300-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90400-3

journal_volume

220

pub_type

杂志文章

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