Expression analysis for inverted effects of serotonin transporter inactivation.

abstract：:A comparative study was conducted between the antiherpetic agents 2'-nor-2'-deoxyguanosine (2'NDG) and acyclovir (ACV) with respect to 1) the relative rates of uptake and phosphorylation to the "active" triphosphate species in tissue culture and 2) the in vitro inhibition of viral and cellular DNA polymerases by their...

journal_title：Biochemical and biophysical research communications

authors： Germershausen J,Bostedor R,Field AK,Perry H,Liou R,Bull H,Tolman RL,Karkas JD

更新日期：1983-10-31 00:00:00

abstract：:Exogenous angiogenin undergoes rapid nuclear translocation in cultured human umbilical artery endothelial cells at 37 degrees C but not at 4 degrees C. Treatment of cells with colchicine, nocodazole and taxol, which disrupt the microtubule system, does not affect the nuclear translocation process of angiogenin, sugges...

journal_title：Biochemical and biophysical research communications

authors： Li R,Riordan JF,Hu G

更新日期：1997-09-18 00:00:00

abstract：:The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting p...

journal_title：Biochemical and biophysical research communications

authors： Zencir S,Ovee M,Dobson MJ,Banerjee M,Topcu Z,Mohanty S

更新日期：2011-08-12 00:00:00

abstract：:The anthrax lethal factor (LF) is a Zn(2+)-endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N-terminal region. Much line of effort was carried out to elucidate the catalytic activity of LF for designing the inhibitor and to understand the cellular mechanism o...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Chai YG,Yoon MY

更新日期：2004-01-02 00:00:00

abstract：:Seven tumors independently derived from a v-Ha-ras-expressing pre-B cell line were examined to determine the oncogene activations cooperating with v-Ha-ras in in vivo tumor progression. The pre-B cell line was generated by infection with Moloney murine leukemia virus (MoMuLV) and a MoMuLV-derived recombinant expressin...

journal_title：Biochemical and biophysical research communications

authors： Chen SC,Redenius D,Schwartz RC

更新日期：1991-08-15 00:00:00

abstract：:The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of the HCV core and its beta-galactosidase fusion proteins in transfected cells were examined by indirect immunofluorescence and cyt...

journal_title：Biochemical and biophysical research communications

authors： Chang SC,Yen JH,Kang HY,Jang MH,Chang MF

更新日期：1994-12-15 00:00:00

abstract：:The ZntR protein from Escherichia coli is a member of the MerR-family of transcriptional regulatory proteins and acts as a hyper-sensitive transcriptional switch primarily in response to Zn(II) and Cd(II). The binding of metal-ions to ZntR initiates a mechanism that remodels the cognate promoter, increasing its affini...

journal_title：Biochemical and biophysical research communications

authors： Khan S,Brocklehurst KR,Jones GW,Morby AP

更新日期：2002-12-06 00:00:00

abstract：:Antigen-specific regulatory CD4(+) T cells have been described but there are few reports on regulatory CD8(+) T cells. We generated islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific regulatory CD8(+) T cells from 8.3-NOD transgenic mice. CD8(+) T cells from 8.3-NOD splenocytes were...

journal_title：Biochemical and biophysical research communications

authors： Kishi M,Yasuda H,Abe Y,Sasaki H,Shimizu M,Arai T,Okumachi Y,Moriyama H,Hara K,Yokono K,Nagata M

更新日期：2010-03-26 00:00:00

abstract：:Infiltration of the tumor microenvironment by macrophages is associated with poor outcomes in breast cancer and other solid tumors, however the identity and roles of many of the soluble factors these macrophages produce remains to be elucidated in detail. In addition to producing angiogenic factors (e.g. VEGF), protea...

journal_title：Biochemical and biophysical research communications

authors： Levano KS,Jung EH,Kenny PA

更新日期：2011-07-22 00:00:00

abstract：:A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It participates to the heterooligomeric, non-DNA binding form of steroid receptors, in association with the heat shock protein of M(r) 90,000 (hsp90). It binds the immunosuppressants FK506 and rapa...

journal_title：Biochemical and biophysical research communications

authors： Le Bihan S,Renoir JM,Radanyi C,Chambraud B,Joulin V,Catelli MG,Baulieu EE

更新日期：1993-09-15 00:00:00

abstract：:Our recent study (Saiki, Y., and Ikemoto, N., Biochemistry 38, 3112-3119, 1999) suggests that Ca2+ release and re-uptake of the released Ca2+ are coordinated. The following results suggest that the coordination is mediated by the luminal Ca2+ ([Ca2+]lum) transient. Upon inducing the release of the passively loaded Ca2...

journal_title：Biochemical and biophysical research communications

authors： Ikemoto N,Yamamoto T

更新日期：2000-12-29 00:00:00

abstract：:Trp140 of E. coli aspartate aminotransferase has been converted to Phe or Gly by site-directed mutagenesis. As compared to the wild-type enzyme, either of the mutant enzymes showed 10- to 100-fold increase in Km's for natural dicarboxylic substrates, but did not show appreciable changes in Km's for aromatic substrates...

journal_title：Biochemical and biophysical research communications

authors： Hayashi H,Inoue Y,Kuramitsu S,Morino Y,Kagamiyama H

更新日期：1990-03-16 00:00:00

abstract：:The reactivity of human thioredoxin (HTR) was tested in several reactions. HTR was as efficient as E. coli or plant and algal thioredoxins when assayed with E. coli ribonucleotide reductase or for the reduction of insulin. On the other hand, HTR was poorly reduced by NADPH and the E. coli flavoenzyme NADPH thioredoxin...

journal_title：Biochemical and biophysical research communications

authors： Jacquot JP,de Lamotte F,Fontecave M,Schürmann P,Decottignies P,Miginiac-Maslow M,Wollman E

更新日期：1990-12-31 00:00:00

abstract：:Lactoferrin (LF) is a multifunctional, iron-binding glycoprotein in mammalian secretions, such as breast milk, and has several beneficial effects for human health. However, how these effects are exerted at the cellular level is still largely unknown. In this study, we investigated the effects of LF on autophagy activi...

journal_title：Biochemical and biophysical research communications

authors： Aizawa S,Hoki M,Yamamuro Y

更新日期：2017-11-04 00:00:00

abstract：:In this study the interactions of oxytocin with the transmembrane region of the oxytocin receptor were modelled in order to explain the selective binding of oxytocin and vasopressin. Three sites of interaction in the receptors were identified by sequence comparison and model building. Both receptors share one site, wh...

journal_title：Biochemical and biophysical research communications

authors： Hakala JM

更新日期：1994-08-15 00:00:00

abstract：:4-Hydroxy-2,3-nonenal is a major aldehydic end-product of lipid peroxidation known to exert several biological and cytotoxic effects and to be produced during conditions of chronic cholestasis. Here we report that viable hepatocytes isolated from cholestatic livers of bile duct-ligated rats (BDL hepatocytes) show a si...

journal_title：Biochemical and biophysical research communications

authors： Leonarduzzi G,Parola M,Muzio G,Garramone A,Maggiora M,Robino G,Poli G,Dianzani MU,Canuto RA

更新日期：1995-09-14 00:00:00

abstract：:Histone deacetylases (HDACs) are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. Deacetylation of epsilon-acetyl-lysine residues within the N-terminal tail of core histones mediates changes in both histone-DNA and histone-non-histone protein interactions. However, surprisin...

journal_title：Biochemical and biophysical research communications

authors： Riester D,Wegener D,Hildmann C,Schwienhorst A

更新日期：2004-11-19 00:00:00

abstract：:Although the extravesicular p40 domain of the transmembrane protein, p65 synaptotagmin (Syt) 1, is essential for the non-classical export of the signal peptide-less structure, FGF1, it was not possible to identify a specific intracellular protease responsible for the processing of p65 Syt1. Surprisingly, analysis of t...

journal_title：Biochemical and biophysical research communications

authors： Bagalá C,Kolev V,Mandinova A,Soldi R,Mouta C,Graziani I,Prudovsky I,Maciag T

更新日期：2003-10-31 00:00:00

abstract：:Eight amino acid permease genes from the protozoan parasite Leishmania donovani (AAPLDs) were cloned, sequenced, and shown to be expressed in promastigotes. Seven of these belong to the amino acid transporter-1 and one to the amino acid polyamino-choline superfamilies. Using these sequences as well as known and charac...

journal_title：Biochemical and biophysical research communications

authors： Akerman M,Shaked-Mishan P,Mazareb S,Volpin H,Zilberstein D

更新日期：2004-12-03 00:00:00

abstract：:Emerging evidence has indicated that transforming growth factor-beta 1 (TGF-β1) induces the epithelial-mesenchymal transition (EMT) in cancer cells, thus promoting their motility and invasiveness. Quercetin, a member of the polyphenolic flavonoid family, has been reported to display anticancer activity against a broad...

journal_title：Biochemical and biophysical research communications

authors： Feng J,Song D,Jiang S,Yang X,Ding T,Zhang H,Luo J,Liao J,Yin Q

更新日期：2018-03-25 00:00:00

abstract：:When TT virus (TTV) DNA was quantitated in whole blood and plasma aliquots from 27 viremic individuals by real-time detection PCR that can detect essentially all TTV genotypes, the TTV load was 6.9 +/- 3.5 (mean +/- standard deviation)-fold higher in the whole blood than in the plasma samples [P < 0.002 (paired t test...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Asabe S,Gotanda Y,Kishimoto J,Tsuda F,Okamoto H

更新日期：2002-01-11 00:00:00

abstract：OBJECT:The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular disease...

journal_title：Biochemical and biophysical research communications

authors： Ikedo T,Minami M,Kataoka H,Hayashi K,Nagata M,Fujikawa R,Yamazaki F,Setou M,Yokode M,Miyamoto S

更新日期：2018-01-01 00:00:00

abstract：:Mouse Msx 1 gene, orthologous of the Drosophila msh, is involved in several developmental processes. BMP family members are major proteins in the regulation of Msx 1 expression. BMP signaling activates Smad 1/5/8 proteins, which associate to Smad 4 before translocating to the nucleus. Analysis of Msx 1 promoter reveal...

journal_title：Biochemical and biophysical research communications

authors： Alvarez Martinez CE,Binato R,Gonzalez S,Pereira M,Robert B,Abdelhay E

更新日期：2002-03-01 00:00:00

abstract：:FENIB (familial encephalopathy with neuroserpin inclusion bodies) is caused by intracellular accumulation/polymerization of mutant neuroserpins in the endoplasmic reticulum (ER). Transgenic rats overexpressing megsin (Tg meg), a newly identified serine protease inhibitor (serpin), demonstrated intraneuronal periodic-a...

journal_title：Biochemical and biophysical research communications

authors： Takano K,Kitao Y,Inagi R,Momoi T,Matsuyama T,Miyata T,Yoneda Y,Iso H,Stern DM,Hori O,Ogawa S

更新日期：2006-08-04 00:00:00

abstract：:This study defines the total sodium-23 magnetic resonance spectroscopy (23Na MRS) signal from in vivo heterotopic rat heart transplants in the early post-transplant period and examines the utility of this noninvasive method for monitoring allograft rejection. Measurements were performed at 4.7 T. Syngeneic (n = 6) and...

journal_title：Biochemical and biophysical research communications

authors： Waldrop SM,Alexander DZ,Lowry R,Winn KJ,Pearson TC,Constantinidis I

更新日期：1996-06-14 00:00:00

abstract：:Human apoprotein(apo) CI and apo AII cDNA probes have been used to analyze the segregation of the human genes in panels of human-mouse hybrids. The apo CI (APOCI) gene segregates with chromosome 19 and the apo AII (APOA2) gene with chromosome 1. Somatic cell hybrids containing chromosome translocations were used to ma...

journal_title：Biochemical and biophysical research communications

authors： Knott TJ,Eddy RL,Robertson ME,Priestley LM,Scott J,Shows TB

更新日期：1984-11-30 00:00:00

abstract：:EAG1 channels belong to the KCNH family of voltage gated potassium channels. They are expressed in several brain regions and increased expression is linked to certain cancer types. Recent cryo-EM structure determination finally revealed the structure of these channels in atomic detail, allowing computational investiga...

journal_title：Biochemical and biophysical research communications

authors： Bernsteiner H,Bründl M,Stary-Weinzinger A

更新日期：2017-02-26 00:00:00

abstract：:Hypoxia inducible factor-1 (HIF-1) is a transcription factor composed of two subunits, HIF-1alpha and ARNT, which is activated under hypoxia. HIF-1alpha mRNA is expressed constitutively in a wide variety of cell types, whereas in some others HIF1A gene expression is upregulated by hypoxia. In this report, we show that...

journal_title：Biochemical and biophysical research communications

authors： Minet E,Ernest I,Michel G,Roland I,Remacle J,Raes M,Michiels C

更新日期：1999-08-02 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) has recently been described to induce antimycobacterial activity. The present study analyses the role played by S1P in antigen presentation of monocytes and in the next activation of Mycobacterium tuberculosis (MTB)-specific CD4+ T cell response. Results reported herein show that S1P stim...

journal_title：Biochemical and biophysical research communications

authors： Santucci MB,Greco E,De Spirito M,Arcovito G,De Angelis G,Cauda R,Fraziano M

更新日期：2007-09-28 00:00:00

abstract：:Recombination in a bovine papillomavirus shuttle vector carrying direct repeats of Moloney murine leukemia virus LTR sequence was examined. Differently from similar vectors carrying direct repeats of SV40 polyA addition signal or neomycin resistance gene, the vector exhibited no homologous recombination between the re...

journal_title：Biochemical and biophysical research communications

authors： Kitamura Y,Naito A,Yoshikura H

更新日期：1991-08-30 00:00:00