Characterization of a Smad motif similar to Drosophila mad in the mouse Msx 1 promoter.

abstract：:The origins and developmental regulation of cerebellar oligodendrocytes are largely unknown, although some hypotheses of embryonic origins have been suggested. Neural stem cells exist in the white matter of postnatal cerebellum, but it is unclear whether these neural stem cells generate oligodendrocytes at postnatal s...

journal_title：Biochemical and biophysical research communications

authors： Naruse M,Shibasaki K,Ishizaki Y

更新日期：2015-08-07 00:00:00

abstract：:Potassium homeostasis plays an essential role in the control of blood pressure. It is unknown, however, whether potassium balance is involved in the gender-associated blood pressure differences. We therefore investigated the possible mechanism of sexual dimorphism in blood pressure regulation by measuring the blood pr...

journal_title：Biochemical and biophysical research communications

authors： Yu G,Cheng M,Wang W,Zhao R,Liu Z

更新日期：2017-04-01 00:00:00

abstract：:The effect of human recombinant interferons (IFNs) alpha and gamma on the transcription of Herpes Simplex virus type-1 (HSV-1) immediate early (IE) genes has been studied. Human amniotic cells (WISH) were transfected with a chimaeric plasmid containing the regulatory region of the HSV-1 IE genes controlling the expres...

journal_title：Biochemical and biophysical research communications

authors： De Stasio PR,Taylor MW

更新日期：1989-03-15 00:00:00

abstract：:Glycoprotein IIIb (GPIV, CD36) has been proposed as the platelet receptor for thrombospondin (TSP). We found two healthy blood donors, whose platelets were shown to be GPIIIb deficient. These platelets expressed endogeneous TSP as control platelets and their binding capacity for exogeneous TSP was the same. These resu...

journal_title：Biochemical and biophysical research communications

authors： Kehrel B,Kronenberg A,Schwippert B,Niesing-Bresch D,Niehues U,Tschöpe D,van de Loo J,Clemetson KJ

更新日期：1991-09-16 00:00:00

abstract：:An early signaling event during the adhesion and spreading of cells is integrin-mediated tyrosine phosphorylation of the cytoskeletal adaptor protein paxillin and the non-receptor tyrosine kinase pp125(FAK) at focal contacts. To determine the influence of surface-charge and -adsorbed adhesion proteins on this signalin...

journal_title：Biochemical and biophysical research communications

authors： Sommerfeldt DW,McLeod KJ,Rubin CT,Hadjiargyrou M

更新日期：2001-07-13 00:00:00

abstract：:It is demonstrated that carbon fixation in photosynthesis is regulated in two kinetically coupled pathways involving the specialized pair of non-equivalent, enzyme-bound glycerate-3-P (3-PGA) molecules obtained from ribulose 1,5-bisphosphate (RuBP) carboxylation in the light. A non-cyclic pathway is suggested (reactio...

journal_title：Biochemical and biophysical research communications

authors： Fong FK,Butcher KA

更新日期：1988-01-15 00:00:00

abstract：:We have used HL-60 leukemia cells to investigate phosphatidylinositol 3-kinase (PI 3-K) during granulocytic differentiation at the nuclear level. Nuclei of HL-60 cells showed a constitutive presence of PI 3-K that increased when cells were treated with differentiating doses of ATRA. PI 3-K was also detected tightly bo...

journal_title：Biochemical and biophysical research communications

authors： Marchisio M,Bertagnolo V,Colamussi ML,Capitani S,Neri LM

更新日期：1998-12-18 00:00:00

abstract：:Exosomes or microvesicles that are secreted from cells are considered to play important roles in tumor microenvironment. Carbonic anhydrase 9 (CA9), which is induced by hypoxia-inducible factor 1 (HIF1) in response to hypoxia, is overexpressed in many types of cancer including renal cell carcinoma (RCC). We examined t...

journal_title：Biochemical and biophysical research communications

authors： Horie K,Kawakami K,Fujita Y,Sugaya M,Kameyama K,Mizutani K,Deguchi T,Ito M

更新日期：2017-10-21 00:00:00

abstract：:Various methods have been used to evaluate anti-fibrotic activity of drugs. However, most of them are complicated, labor-intensive and lack of efficiency. This study was intended to develop a rapid method for anti-fibrotic drugs screening based on biophysical properties. A549 cells in vitro were stimulated with transf...

journal_title：Biochemical and biophysical research communications

authors： Liu M,Zheng M,Xu H,Liu L,Li Y,Xiao W,Li J,Ma E

更新日期：2015-12-04 00:00:00

abstract：:We have compared the sequence and gene order of meta-cleavage pathway operons from alpha- and gamma-subgroups of the Proteobacteria with operons from Burkholderia sp. strain RP007 which belongs to the beta-subgroup of the Proteobacteria. Burkholderia RP007 was isolated for its ability to degrade phenanthrene and conta...

journal_title：Biochemical and biophysical research communications

authors： Laurie AD,Lloyd-Jones G

更新日期：1999-08-19 00:00:00

abstract：:With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time. The results show PO 200 μM + XSS 10 μM, PO 300 μM + XSS 15 μM, and PO 400 μM + XSS 20 μM can significantly increase the level of uric acid in the zebrafish...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Li Q,Wang F,Xing C

更新日期：2019-01-08 00:00:00

abstract：:Single-molecule imaging by scanning tunnelling microscopy (STM) yields the atomic-resolution (0.6A) structure of individual B-type DNA molecules. The strong correlation between these STM structures and those predicted from the known base sequence indicates that sequencing of single DNA molecules using STM may be feasi...

journal_title：Biochemical and biophysical research communications

authors： Zareie MH,Lukins PB

更新日期：2003-03-28 00:00:00

abstract：:Fungi, particularly the white rot basidiomycetes, have an extraordinary capability to degrade and/or mineralize (to CO(2)) the recalcitrant fused-ring high molecular weight (4 aromatic-rings) polycyclic aromatic hydrocarbons (HMW PAHs). Despite over 30years of research demonstrating involvement of P450 monooxygenation...

journal_title：Biochemical and biophysical research communications

authors： Syed K,Doddapaneni H,Subramanian V,Lam YW,Yadav JS

更新日期：2010-09-03 00:00:00

abstract：:RANTES is a potent chemotactic and activating agent for a variety of leukocytes including T-lymphocytes. To identify the region of the molecule responsible for this activity, we have made overlapping 10 amino acid peptides scanning the protein. A micro-Boyden chamber chemotaxis assay showed the most efficacious peptid...

journal_title：Biochemical and biophysical research communications

authors： Wells TN,Guye-Coulin F,Bacon KB

更新日期：1995-06-06 00:00:00

abstract：:A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 mumoles of W-7, reaching a maximum of 86% after 5 min. Reduction in sp...

journal_title：Biochemical and biophysical research communications

authors： Nishino H,Fujiki H,Suganuma M,Horiuchi T,Iwashima A,Sugimura T

更新日期：1984-11-14 00:00:00

abstract：:Casein kinase II (CKII) activity in colorectal tumours was compared before and after heterotransplantation onto nude mice. The test revealed that the enzyme activity was about two-fold enhanced in the tumours isolated from the nude mice when compared to the respective primary tumours from which they were derived. Immu...

journal_title：Biochemical and biophysical research communications

authors： Seitz G,Münstermann U,Schneider HR,Issinger OG

更新日期：1989-08-30 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the synergistic effect of paclitaxel (PTX) and verapamil (VERA) on adriamycin (ADR)-resistant breast cancer (MCF-7/ADR) cells. METHODS:ATP-PCA was applied to determine the inhibitory effects of PTX combined with VERA on MCF-7/ADR cells. Edu, CCK-8 and Flow cytometry ...

journal_title：Biochemical and biophysical research communications

authors： Li P,Zhong D,Gong PY

更新日期：2019-08-13 00:00:00

abstract：:The ability of paraquat, MPP+, and analogs to be reduced by chemical reductants and by NADPH, as catalyzed by liver microsomes or purified NADPH cytochrome P-450 reductase, is reported. The analogs span a range of electrochemical potential, including values in-between that of paraquat and MPP+. Analogs with an Eo belo...

journal_title：Biochemical and biophysical research communications

authors： Frank DM,Arora PK,Blumer JL,Sayre LM

更新日期：1987-09-30 00:00:00

abstract：BACKGROUND:Quercetin is a plant polyphenol from the flavonoid group that plays a fundamental role in controlling homeostasis due to its potent antioxidant properties. However, quercetin has extremely low water solubility, which is a major challenge in drug absorption. METHOD:In this study, we described a simple method...

journal_title：Biochemical and biophysical research communications

authors： Aghapour F,Moghadamnia AA,Nicolini A,Kani SNM,Barari L,Morakabati P,Rezazadeh L,Kazemi S

更新日期：2018-06-12 00:00:00

abstract：:The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identica...

journal_title：Biochemical and biophysical research communications

authors： Gullberg U,Widegren B,Arnason U,Egesten A,Olsson I

更新日期：1986-09-30 00:00:00

abstract：:The efficacy and specificity of a novel synthetic thrombin inhibitor, DuP 714, on thrombin-induced elevation of cytoplasmic calcium, fibrinogen binding and aggregation in human platelets were examined. Thrombin (0.5 U/ml) stimulated an increase in [125I]fibrinogen binding in gel-filtered platelets which was blocked by...

journal_title：Biochemical and biophysical research communications

authors： Chiu AT,Mousa SA,Pease LJ,Roscoe WA,Bozarth JM,Reilly TM,Smith RD,Timmermans PB

更新日期：1991-09-30 00:00:00

abstract：:N1999A2 (NA2) is a new non-protein antitumor antibiotic that contains a stable 9-membered ring enediyne chromophore similar to a neocarzinostatin chromophore (NCS-chr). We have compared DNA cleavage reactions between NA2 and NCS-chr, and also clarified some characteristics of DNA strand scission by NA2. It was found t...

journal_title：Biochemical and biophysical research communications

authors： Miyagawa N,Sasaki D,Matsuoka M,Imanishi M,Ando T,Sugiura Y

更新日期：2003-06-20 00:00:00

abstract：:Human artificial chromosome (HAC) has several advantages as a gene therapy vector, including stable episomal maintenance and the ability to carry large gene inserts. Induced pluripotent stem (iPS) cells also have a great potential for gene therapy, which can be generated from an individual's own tissues and contribute...

journal_title：Biochemical and biophysical research communications

authors： Yakura Y,Ishihara C,Kurosaki H,Kazuki Y,Komatsu N,Okada Y,Doi T,Takeya H,Oshimura M

更新日期：2013-02-08 00:00:00

abstract：:Insect development is controlled by the combined actions of ecdysteroid and juvenile hormones. Transcriptional control by ecdysteroid hormones is mediated via two nuclear receptor superfamily members, ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle (USP). Although the ecdysteroid hormone 20-hydrox...

journal_title：Biochemical and biophysical research communications

authors： Maki A,Sawatsubashi S,Ito S,Shirode Y,Suzuki E,Zhao Y,Yamagata K,Kouzmenko A,Takeyama K,Kato S

更新日期：2004-07-16 00:00:00

abstract：:To determine whether insulin resistance increases expression of plasminogen activator inhibitor type-1 (PAI-1) in the heart, studies were performed in 22 mice with and 38 without myocardial infarction. Insulin resistance in transgenic animals genetically rendered insulin resistant was confirmed with the use of intrape...

journal_title：Biochemical and biophysical research communications

authors： Sobel BE,Schneider DJ,Lee YH,Pratley RE

更新日期：2006-07-21 00:00:00

abstract：:Unlike unsaturated fatty acids, which almost fully activated purified brain protein kinase C in a phosphatidylserine- and Ca2(+)-free reaction, related methyl esters were poorly active in vitro. In contrast, methyl arachidonate was revealed to be as potent as arachidonic acid in activating protein kinase C in intact p...

journal_title：Biochemical and biophysical research communications

authors： Fan XT,Huang XP,Da Silva C,Castagna M

更新日期：1990-06-29 00:00:00

abstract：:Treatment with double-stranded RNA (dsRNA) has been shown to interfere with the function of specific genes in various invertebrate species. However, it has not yet been reported that this technique can be applied to vertebrates as well. We have investigated whether dsRNA treatment will inhibit gene function in zebrafi...

journal_title：Biochemical and biophysical research communications

authors： Wargelius A,Ellingsen S,Fjose A

更新日期：1999-09-16 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known immunotoxic compound affecting the expression of inflammatory genes. We found that TCDD induces the expression of the B-cell activating factor of the tumor necrosis factor family (BAFF), B-lymphocyte chemoattractant (BLC), CC-chemokine ligand 1 (CCL1), and the...

journal_title：Biochemical and biophysical research communications

authors： Vogel CF,Sciullo E,Matsumura F

更新日期：2007-11-23 00:00:00

abstract：:DNA topoisomerase II (Topo II) is an essential enzyme that catalyzes topological changes of DNA and consists of a major member of mitotic chromosomes. To investigate the dynamic localization of Topo II in nuclei, we engineered the strain of Aspergillus nidulans expressing Topo II fused with green fluorescent protein (...

journal_title：Biochemical and biophysical research communications

authors： Kawagishi M,Akashi T,Kikuchi A

更新日期：2005-08-26 00:00:00

abstract：:Small heterodimer partner (SHP; NR0B2) is an orphan nuclear receptor and acts as a repressor for wide variety of nuclear hormone receptors. We demonstrated here that mouse SHP mRNA showed a circadian expression pattern in the liver. Transient transfection of the mSHP promoter demonstrated that CLOCK-BMAL1, core circad...

journal_title：Biochemical and biophysical research communications

authors： Oiwa A,Kakizawa T,Miyamoto T,Yamashita K,Jiang W,Takeda T,Suzuki S,Hashizume K

更新日期：2007-02-23 00:00:00