Insulin resistance increases PAI-1 in the heart.

abstract：:The pattern of micrococcal nuclease digestion of chromatin from different organs of Allium cepa has been studied. The DNA from small oligonucleosomes appears to be highly degraded and heterogeneous. In solutions of intermediate ionic strength (0.15 M NaCl) histones H2A and H2B form dimers, however at high salt concent...

journal_title：Biochemical and biophysical research communications

authors： Moreno ML,Puigdomenech P,Palau J

更新日期：1985-06-28 00:00:00

abstract：:Abnormal proliferation of vascular smooth muscle cells is a key event in the formation of atherosclerotic plaques in humans. It has been suggested that modulation of platelet derived growth factor chain A (PDGF-A) gene expression may contribute to atherosclerosis. Using an 'in situ hybridization' technique the present...

journal_title：Biochemical and biophysical research communications

authors： Zwijsen RM,Japenga SC,Heijen AM,van den Bos RC,Koeman JH

更新日期：1992-08-14 00:00:00

abstract：:The ability to identify apoptotic cells within a complex population is crucial in the research and diagnosis of normal physiology and disease states. The Cellscan mark S (CS-S) cytometer was used in this study to detect intracellular fluorescence intensity and polarization (FI and FP) in several well-established model...

journal_title：Biochemical and biophysical research communications

authors： Zurgil N,Schiffer Z,Shafran Y,Kaufman M,Deutsch M

更新日期：2000-02-05 00:00:00

abstract：:An insect antiviral compound was purified from Heliothis virescens larval hemolymph by gel-filtration high pressure liquid chromatography (HPLC) and C-18 reverse-phase HPLC and its structure was determined by mass spectrometry. The antiviral compound is an N-myristoylated-peptide containing six amino acids with calcul...

journal_title：Biochemical and biophysical research communications

authors： Ourth DD

更新日期：2004-07-16 00:00:00

abstract：:Cytosolic free calcium concentration ([Ca(2+)]i) is a central signalling element for the maintenance of endothelial barrier function. Under physiological conditions, it is controlled within narrow limits. Metabolic inhibition during ischemia/reperfusion, however, induces [Ca(2+)]i overload, which results in barrier fa...

journal_title：Biochemical and biophysical research communications

authors： Bosche B,Schäfer M,Graf R,Härtel FV,Schäfer U,Noll T

更新日期：2013-05-03 00:00:00

abstract：:The death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine...

journal_title：Biochemical and biophysical research communications

authors： Vauzour D,Vafeiadou K,Spencer JP

更新日期：2007-10-19 00:00:00

abstract：:Total RNA isolated from a rainbow trout (Oncorhynchus mykiss) liver was subjected to RT/PCR using degenerate primers designed from homologous regions amongst cytochrome P450 CYP4 proteins. PCR amplification resulted in a single electrophoretic band which was excised, purified and sequenced directly, using cycle sequen...

journal_title：Biochemical and biophysical research communications

authors： Falckh PH,Wu QK,Ahokas JP

更新日期：1997-07-18 00:00:00

abstract：:Members of the heparan sulfate proteoglycan family, the syndecans have emerged as integrators of extracellular signals, such as ECM components or growth factors, that activate cytoplasmic signaling cascades and regulate cytoskeletal functions. Specifically, syndecan-2 has been implicated in various cellular processes,...

journal_title：Biochemical and biophysical research communications

authors： Contreras HR,Fabre M,Granés F,Casaroli-Marano R,Rocamora N,Herreros AG,Reina M,Vilaró S

更新日期：2001-08-31 00:00:00

abstract：:Previously, we reported the identification and characterization of a novel cancer/testis antigen gene, CAGE(4), that was expressed in various histological types of tumors, but not in normal tissues, with the exception of the testis. To date, molecular mechanisms for the expression of CAGE have never been studied. In o...

journal_title：Biochemical and biophysical research communications

authors： Cho B,Lee H,Jeong S,Bang YJ,Lee HJ,Hwang KS,Kim HY,Lee YS,Kang GH,Jeoung DI

更新日期：2003-07-18 00:00:00

abstract：:The present study demonstrates that exposure of human thyroid slices to thyrotropin causes an increase in phospholipid metabolism as measured by an increased incorporation of myo-2-[3H]-inositol into phosphatidylinositol, the generation of InsP3 and formation of GInsP as well as metabolism of phosphatidylcholine and p...

journal_title：Biochemical and biophysical research communications

authors： Mosko P,Zarzycki W,Jaroszewicz L,Kinalska I

更新日期：1994-06-30 00:00:00

abstract：:In the presence of 1 mM EGTA, the addition of the calcium ionophore ionomycin to human platelets loaded with 30 microM fura-2 could elevate [Ca2+]i from less than 100 nM to a maximum of greater than 3 microM, presumably by discharge of Ca2+ from internal stores. Under the same conditions thrombin could maximally incre...

journal_title：Biochemical and biophysical research communications

authors： Pollock WK,Rink TJ

更新日期：1986-08-29 00:00:00

abstract：:We previously described the isolation of CDK4, representing the 3(')end of an unknown mRNA, using differential display [Biophys. Res. Commun. 232 (1997) 49]. To determine the identity of the CDK4 gene, full-length CDK4 cDNA clones were isolated from a diabetic kidney cDNA library. DNA sequencing revealed that CDK4 rep...

journal_title：Biochemical and biophysical research communications

authors： Page RA,Malik AN

更新日期：2003-10-17 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha) and interleukin-6 (IL-6), both known to be able to open the blood-brain barrier (BBB), downregulated plasma membrane-associated tyrosine phosphatase activity in primary porcine brain endothelial cells (PBEC). In contrast, transforming growth factor beta (TGF-beta) upregulated PTP activ...

journal_title：Biochemical and biophysical research communications

authors： Gloor SM,Weber A,Adachi N,Frei K

更新日期：1997-10-29 00:00:00

abstract：:Oxidation of low-density lipoproteins (LDLs) induces development of cardiovascular disease. Recently, reports of studies using atomic force microscopy (AFM) have described that the elastic modulus of metal-induced oxidized LDLs is lower than the modulus before oxidation. However, the mechanisms of change of the elasti...

journal_title：Biochemical and biophysical research communications

authors： Takeda S,Sakurai T,Hui SP,Fuda H,Chiba H

更新日期：2018-06-27 00:00:00

abstract：:G-protein-coupled receptor 120 (GPR120) and GPR40 exhibit a variety of biological responses by the binding of free fatty acids. 12-O-Tetradecanoylphorbol-13-acetate (TPA) is a tumor promoting agent of skin carcinogenesis. It is known that TPA treatment stimulates cell motile activity of cancer cells, including melanom...

journal_title：Biochemical and biophysical research communications

authors： Fukushima K,Takahashi K,Fukushima N,Honoki K,Tsujiuchi T

更新日期：2016-06-17 00:00:00

abstract：:The cell membrane receptor for epidermal growth factor (EGF) appears to be a glycoprotein of Mr 170,000 and mediates the mitogenic and metabolic responses of cells with EGF receptors (EGF-R). Normal rat kidney (NRK) have about 3 X 10(5) EGF-R per cell. Upon transformation of NRK cells by Kirsten sarcoma virus, the tra...

journal_title：Biochemical and biophysical research communications

authors： Chua CC,Geiman DE,Schreiber AB,Ladda RL

更新日期：1984-01-30 00:00:00

abstract：:The selectivity filter and adjacent regions in the bacterial KcsA and inwardly rectifying K(+) (Kir) channels reveal significant conformational changes that cause the channel pore to transition from an activated to inactive state (C-type inactivation) once the channel is open. The meshwork of residues stabilizing the ...

journal_title：Biochemical and biophysical research communications

authors： Raja M

更新日期：2011-09-16 00:00:00

abstract：:Concomitant with the depletion of glutathione content, phorone (250 mg/kg, ip.) produced a marked increase in heme oxygenase activity, biphasic effect on delta-aminolevulinic acid synthetase activity, and slight decreases in cytochrome P-450 content and aminopyrine demethylase activity in the liver of rats. The increa...

journal_title：Biochemical and biophysical research communications

authors： Yoshida T,Oguro T,Numazawa S,Kuroiwa Y

更新日期：1987-05-29 00:00:00

abstract：:Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vas...

journal_title：Biochemical and biophysical research communications

authors： Hata F,Ishii T,Kanada A,Yamano N,Kataoka T,Takeuchi T,Yagasaki O

更新日期：1990-11-15 00:00:00

abstract：:Pain is a common symptom of injuries and inflammatory-related conditions. The perception of pain, commonly known as nociception, depends on integrated receptors and molecular pathways. Inflammatory mediators are involved in the genesis, persistence, and severity of pain. Noxious stimuli can trigger a cascade of inflam...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2007-02-09 00:00:00

abstract：:Multi electrode arrays (MEAs) are increasingly used to detect external field potentials in electrically active cells. Recently, in combination with cardiomyocytes derived from human (induced) pluripotent stem cells they have started to become a preferred tool to examine newly developed drugs for potential cardiac toxi...

journal_title：Biochemical and biophysical research communications

authors： Tertoolen LGJ,Braam SR,van Meer BJ,Passier R,Mummery CL

更新日期：2018-03-18 00:00:00

abstract：:COOH-terminal cytoplasmic domains of G protein-coupled receptors (GPCRs) have been shown to carry determinants that control their cell surface localization, internalization, and recycling. In attempts to seek cellular proteins that mediate these processes of PTH/PTH-related protein receptor (PTHR), one of the class B ...

journal_title：Biochemical and biophysical research communications

authors： Sugai M,Saito M,Sukegawa I,Katsushima Y,Kinouchi Y,Nakahata N,Shimosegawa T,Yanagisawa T,Sukegawa J

更新日期：2003-11-07 00:00:00

abstract：:Examination of human follicular fluid revealed the presence of polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs) at concentrations of approximately 1 pg/ml (0.01 pg TEQ/ml). To study their possible action, two-cell mouse embryos were cultured in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumi O,Uechi H,Sone H,Yonemoto J,Takai Y,Momoeda M,Tohyama C,Hashimoto S,Morita M,Taketani Y

更新日期：1998-09-18 00:00:00

abstract：:The transcription of human nm23 genes (nm23-H1, nm23-H2) is involved in suppression of tumor metastasis or tumor progression. Therefore the characterization of transcriptional regulatory mechanisms for both nm23 genes is very important. In this study we have isolated and analyzed the 5'-flanking region of the human nm...

journal_title：Biochemical and biophysical research communications

authors： Seifert M,Seib T,Engel M,Dooley S,Welter C

更新日期：1995-10-24 00:00:00

abstract：:Ornithine decarboxylase (ODC), which catalyzes polyamine biosynthesis, plays an essential role in cell growth. DL-alpha-Difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, inhibits cell growth. However, the exact mechanism by which polyamine depletion by DFMO results in growth inhibition remains to be elucid...

journal_title：Biochemical and biophysical research communications

authors： Nemoto T,Kamei S,Seyama Y,Kubota S

更新日期：2001-01-26 00:00:00

abstract：:An important role for the Rel/NF-kappaB family of transcription factors in the differentiation process of dendritic cells (DC) and macrophages (MAC) was recently suggested by a number of mouse knockout studies but only little information is available for defined populations of human cells. To investigate the role of i...

journal_title：Biochemical and biophysical research communications

authors： Ammon C,Mondal K,Andreesen R,Krause SW

更新日期：2000-02-05 00:00:00

abstract：:The expression of the ibpAibpB heat-shock operon of Escherichia coli was found previously not to conform to the known pattern of expression of the sigma(32)-regulated operons because the rpoH gene mutation inactivating the sigma(32) protein did not abolish the ibp induction. We show here that this effect can depend pa...

journal_title：Biochemical and biophysical research communications

authors： Kuczyńska-Wisńik D,Laskowska E,Taylor A

更新日期：2001-06-01 00:00:00

abstract：:We have studied the oligosaccharide chains of the variant surface glycoprotein (VSG) of Trypanosoma brucei brucei MITat 1.6. Glycopeptides were generated by Pronase digestion, purified by gel permeation and ion-exchange chromatography, and structurally characterized by 1H and 31P NMR spectroscopy in combination with c...

journal_title：Biochemical and biophysical research communications

authors： Strang AM,Allen AK,Holder AA,van Halbeek H

更新日期：1993-11-15 00:00:00

abstract：:Down syndrome (DS, Trisomy 21) is the most common genetic cause of delayed fetal brain development and postnatal intellectual disability. Although delayed fetal brain development might be involved in intellectual disability, no evidence of an association between these abnormal phenotypes has been shown. To identify mo...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Ishihara K,Kawashita E,Sago H,Yamakawa K,Mizutani KI,Akiba S

更新日期：2021-01-08 00:00:00

abstract：:Atherosclerotic plaque rupture is the main cause of acute coronary syndrome (ACS). Angiotensin II (Ang II) and macrophage apoptosis are involved in the pathogenesis of atherosclerosis. However, the underlying mechanisms remain unclear. We aimed to address the role of monocyte chemotactic protein-induced protein 1 (MCP...

journal_title：Biochemical and biophysical research communications

authors： Shu S,Zhang Y,Li W,Wang L,Wu Y,Yuan Z,Zhou J

更新日期：2019-07-23 00:00:00