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Activation of bovine photoreceptor guanylate cyclase by S100 proteins.

Abstract：

:S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyclase. The extent of stimulation varied between the different S100 proteins with the S100b exhibiting the highest level of influence. The stimulation by all S100 proteins was calcium dependent, with the half-maximal stimulation occurring at about 35-40 microM calcium. These results suggest that in some cells S100 proteins can mediate calcium signals via cyclic GMP.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Margulis A,Pozdnyakov N,Sitaramayya A

doi

10.1006/bbrc.1996.0043

subject

Has Abstract

pub_date

1996-01-05 00:00:00

pages

243-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90043-1

journal_volume

218

pub_type

杂志文章

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