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Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes.

Abstract：

:Imipenem is often used to treat intensive care unit patients infected by Enterobacter aerogenes, but it is leading to an increasing number of antibiotic resistant strains. Clinical isolates and imipenem resistant variants presented a high level of resistance to beta-lactam antibiotic group and to chemically unrelated drugs. We report here that imipenem selects strains which contain active efflux pumps ejecting various unrelated antibiotics including quinolones, tetracycline, and chloramphenicol. An increase of AcrA, an efflux pump component, was observed in the imipenem resistant variants. The overexpression of marA, involved in the genetic control of membrane permeability via porin and efflux pump expression, indicated the activation of the resistance genetic cascade in imipenem resistant variants.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Bornet C,Chollet R,Malléa M,Chevalier J,Davin-Regli A,Pagès JM,Bollet C

doi

10.1016/s0006-291x(03)00074-3

subject

Has Abstract

pub_date

2003-02-21 00:00:00

pages

985-90

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X03000743

journal_volume

301

pub_type

杂志文章

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