Inhibition of gastric pepsin secretion by peripherally or centrally injected interleukin-1 in rats.

abstract：:Deoxynucleoside analogues (dNAs) are cytotoxic towards both replicating and indolent malignancies. The impact of fluctuations in the metabolism of dNAs in relation to cell cycle could have strong implications regarding the activity of dNAs. Deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) are important enzym...

journal_title：Biochemical and biophysical research communications

authors： Fyrberg A,Albertioni F,Lotfi K

更新日期：2007-06-15 00:00:00

abstract：:An ubiquinone-binding protein (QP) was purified from mitochondrial NADH-ubiquinone reductase (Complex I). Complex I was separated into 3 fragments: a fraction of hydrophobic proteins, that of soluble iron-sulfur protein (IP) and soluble NADH dehydrogenase of flavoprotein by a procedure involving the resolution with DO...

journal_title：Biochemical and biophysical research communications

authors： Suzuki H,Ozawa T

更新日期：1986-08-14 00:00:00

abstract：:Hypoxia inducible factor-1 (HIF-1) is a transcription factor composed of two subunits, HIF-1alpha and ARNT, which is activated under hypoxia. HIF-1alpha mRNA is expressed constitutively in a wide variety of cell types, whereas in some others HIF1A gene expression is upregulated by hypoxia. In this report, we show that...

journal_title：Biochemical and biophysical research communications

authors： Minet E,Ernest I,Michel G,Roland I,Remacle J,Raes M,Michiels C

更新日期：1999-08-02 00:00:00

abstract：:Standardized RT-PCR (StaRT-PCR) enables numerical quantification as well as intra- and inter-laboratory comparison of gene expression. Multiplex StaRT-PCR, using two rounds of amplification, was conducted on Stratagene Universal Reference RNA. In the first round, cDNA, competitive template (CT) mix, and primers for up...

journal_title：Biochemical and biophysical research communications

authors： Crawford EL,Warner KA,Khuder SA,Zahorchak RJ,Willey JC

更新日期：2002-04-26 00:00:00

abstract：:A phosphoprotein with associated tyrosine kinase activity has been purified from a 26,000 x g particulate fraction of rat spleen. The molecular weight of the native kinase is 85-90 kDa as estimated by gel permeation chromatography on Superdex 200 while SDS/PAGE of an autophosphorylated sample indicated a single 28-kDa...

journal_title：Biochemical and biophysical research communications

authors： Borowski P,Medem S,Laufs R

更新日期：1993-07-30 00:00:00

abstract：:Polymerization of actin induced by activation of platelets was investigated using deoxyribonuclease I inhibition assay. When platelets were activated with ADP or 5-hydroxytryptamine, actin was polymerized quickly followed by rapid depolymerization to the initial level. Reactivation with the same agonist, however, did ...

journal_title：Biochemical and biophysical research communications

authors： Imada T,Kikuchi T,Shimada H,Inada Y,Saito Y

更新日期：1984-05-16 00:00:00

abstract：:We prepared a cleavage site-directed antiserum against Caspase-3 (anti-p20/17), which reacts with the p20/17 fragment (p20/17) activated by cleavage but not proCaspase-3 (p32), and examined the relationship between the activation of Caspase-3 and apoptosis. We identified p20/17-positive cells where cell death occurs n...

journal_title：Biochemical and biophysical research communications

authors： Kouroku Y,Urase K,Fujita E,Isahara K,Ohsawa Y,Uchiyama Y,Momoi MY,Momoi T

更新日期：1998-06-29 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in human NOTCH3. We have recently reported that mutant Notch3 shows a greater propensity to form aggregates, and these aggregates resist degradation, leading to accumulation in the endoplasmic re...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Adachi K,Kunimoto S,Wakita H,Takeda K,Watanabe A

更新日期：2010-11-05 00:00:00

abstract：:This study characterized the magnetic materials found within Daphnia resting eggs by measuring static magnetization with a superconducting quantum interference device (SQUID) magnetometer, after forming two types of conditions, each of which consists of zero-field cooling (ZFC) and field cooling (FC). Magnetic ions, s...

journal_title：Biochemical and biophysical research communications

authors： Sakata M,Kawasaki T,Shibue T,Takada A,Yoshimura H,Namiki H

更新日期：2006-12-15 00:00:00

abstract：:The trans-translation system in bacteria promotes recycling of stalled ribosomes and targets incomplete peptides for proteolysis. In Escherichia coli, loss of trans-translation function has little effect on growth under normal laboratory conditions. Among the subtle phenotypes of tmRNA-deficient mutants is the inabili...

journal_title：Biochemical and biophysical research communications

authors： O'Connor M

更新日期：2007-05-25 00:00:00

abstract：:Several rich sources of polyphenols stimulate the endothelial formation of nitric oxide (NO), a potent vasoprotecting factor, via the redox-sensitive activation of the PI3-kinase/Akt pathway leading to the phosphorylation of endothelial NO synthase (eNOS). The present study examined the molecular mechanism underlying ...

journal_title：Biochemical and biophysical research communications

authors： Auger C,Kim JH,Chabert P,Chaabi M,Anselm E,Lanciaux X,Lobstein A,Schini-Kerth VB

更新日期：2010-02-26 00:00:00

abstract：:Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making FAS II enzymes excellent targets for antibiotics discovery. The beta-hydroxyacyl-ACP dehydratase (FabZ) catalyzes an essentia...

journal_title：Biochemical and biophysical research communications

authors： Kirkpatrick AS,Yokoyama T,Choi KJ,Yeo HJ

更新日期：2009-03-06 00:00:00

abstract：:The complex of immobilized human plasminogen (iHPlg) and streptokinase (SK) has a lower catalytic activity in hydrolysis of plasmin-specific substrate S-2251 with a kcat/Km of 0.005 microM-1 x s-1, compared to 0.031 microM-1 x s-1 of immobilized human plasmin (iHPlm) and 0.078 microM-1 x s-1 of HPlm. The SK in the com...

journal_title：Biochemical and biophysical research communications

authors： Shi GY,Chang BI,Wu DH,Wu HL

更新日期：1993-08-31 00:00:00

abstract：:We have previously shown that the protein encoded by a human insulin-like growth factor I (IGF-I) receptor cDNA binds both IGF-I and II with high affinity. In the present studies, we show that a monoclonal antibody to the IGF-I receptor, alpha IR-3, inhibits the binding of IGF-I but not IGF-II to the expressed recepto...

journal_title：Biochemical and biophysical research communications

authors： Steele-Perkins G,Roth RA

更新日期：1990-09-28 00:00:00

abstract：:The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs p...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Xu H,Park EJ,Philbert MA,Kopelman R

更新日期：2008-05-02 00:00:00

abstract：:Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 microM with 4-h...

journal_title：Biochemical and biophysical research communications

authors： He Q,Khanna P,Srivastava S,van Kuijk FJ,Ansari NH

更新日期：1998-06-29 00:00:00

abstract：:The proliferation of colon cancer cells is mediated in part by epidermal growth factor receptor (EGFR) signaling and requires sustained levels of cellular energy to meet its high metabolic needs. Intracellular lipid droplets (LDs) are a source of energy used for various cellular functions and they are elevated in dens...

journal_title：Biochemical and biophysical research communications

authors： Penrose H,Heller S,Cable C,Makboul R,Chadalawada G,Chen Y,Crawford SE,Savkovic SD

更新日期：2016-01-15 00:00:00

abstract：:Vasopressin (VP) rapidly increased 45Ca2+ efflux. A VP antagonist prevented VP from mobilizing Ca2+ and stimulating DNA synthesis. Prostaglandin F2 alpha (PGF2 alpha) also stimulated rapid 45Ca2+ release. The effectiveness of different prostaglandins corresponded to their effectiveness as mitogens. The removal of exte...

journal_title：Biochemical and biophysical research communications

authors： Smith JB,Smith L

更新日期：1984-09-17 00:00:00

abstract：:Chemical modifiers (radiosensitizers) are used in order to increase the efficacy of radiotherapy. The use of Photodynamic Therapy for tumor treatment, especially with Photofrin II, is also known. At present, no chemical modifier has been found to act as a selective radiosensitizer. Experiments using several series of ...

journal_title：Biochemical and biophysical research communications

authors： Kulka U,Schaffer M,Siefert A,Schaffer PM,Olsner A,Kasseb K,Hofstetter A,Dühmke E,Jori G

更新日期：2003-11-07 00:00:00

abstract：:The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. Little is known about the mechanisms underlying this process. We report here the identification of a novel member of BNIPL family, designated Bcl-2/adenovirus E1B 19kDa interacting pro...

journal_title：Biochemical and biophysical research communications

authors： Qin W,Hu J,Guo M,Xu J,Li J,Yao G,Zhou X,Jiang H,Zhang P,Shen L,Wan D,Gu J

更新日期：2003-08-22 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Wang H,Duan Y,Yang H

更新日期：2020-11-21 00:00:00

abstract：:cGMP-Phosphodiesterase 6 (PDE6) is the central effector enzyme in the phototransduction system of vertebrate photoreceptors. We have recently found that PDE6 accumulates in a detergent-resistant membrane (DRM) fraction in response to excitation of bovine rod phototransduction system. Here, we studied the molecular mec...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Seno K,Hayashi F

更新日期：2003-03-28 00:00:00

abstract：:Spontaneous Arg- mutants arose at high frequencies in Streptomyces lividans. Exposure to ethidium bromide increased the frequency of arg instability. In Pro+ strains the induced arg mutants were mainly argG, but in the proB mutants, a new mutation, argJ, prevailed which lacked ornithine acetyltransferase activity and ...

journal_title：Biochemical and biophysical research communications

authors： Chou CF,Chen CW

更新日期：1992-12-15 00:00:00

abstract：:Insect midgut peritrophic membrane (PM) is a functional structure that protects insects against chemical damage and microorganism infection. The essential component in PM is chitin and its synthesis is catalyzed by Class B chitin synthase (CHSB), which plays a unique role in chitin-containing organisms and thus repres...

journal_title：Biochemical and biophysical research communications

authors： Qu M,Liu T,Yang J,Yang Q

更新日期：2011-01-07 00:00:00

abstract：:Peroxisomes catalyze a number of essential metabolic functions especially related to lipid metabolism. There is increasing evidence suggesting that peroxisomes are also involved in the synthesis of isoprenoids via the mevalonate pathway at least in rat liver. In order to obtain independent evidence for a role of perox...

journal_title：Biochemical and biophysical research communications

authors： Wanders RJ,Romeijn GJ

更新日期：1998-06-29 00:00:00

abstract：:Artificial DNA binding peptides recognizing separated sequences would expand varieties of the target genes for desirable transcriptional control. Here we demonstrated that polyarginine linker between two 3-zinc finger domains gives DNA binding selectivity to the separated target sequences. We created a six-zinc finger...

journal_title：Biochemical and biophysical research communications

authors： Imanishi M,Yan W,Morisaki T,Sugiura Y

更新日期：2005-07-22 00:00:00

abstract：:The mechanism(s) involved in the generation of free radicals in human leukocytes by phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMP), lipopolysaccharide (LPS), arachidonic acid (AA), and recombinant-tumor necrosis factor-1-alpha (r-TNF-1 alpha) was investigated. Calmodulin antagonists, chlo...

journal_title：Biochemical and biophysical research communications

authors： Das UN,Padma M,Sagar PS,Ramesh G,Koratkar R

更新日期：1990-03-30 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) is a potent mutagen found in cooked food. MeIQx and its isotopically labelled (13C, 15N2 and 14C) analogues were synthesised and used for metabolic studies in vivo. An equimolar mixture of MeIQx and its 13C, 15N2 stable isotope labelled analogue (containing tracer ...

journal_title：Biochemical and biophysical research communications

authors： Gooderham NJ,Watson D,Rice JC,Murray S,Taylor GW,Davies DS

更新日期：1987-11-13 00:00:00

abstract：:Pain is a common symptom of injuries and inflammatory-related conditions. The perception of pain, commonly known as nociception, depends on integrated receptors and molecular pathways. Inflammatory mediators are involved in the genesis, persistence, and severity of pain. Noxious stimuli can trigger a cascade of inflam...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2007-02-09 00:00:00

abstract：:Macroautophagy is a conserved degradative pathway and its deterioration is linked to disturbances in cellular proteostasis and multiple diseases. Here, we show that the RAB GTPase RAB18 modulates autophagy in primary human fibroblasts. The knockdown of RAB18 results in a decreased autophagic activity, while its overex...

journal_title：Biochemical and biophysical research communications

authors： Feldmann A,Bekbulat F,Huesmann H,Ulbrich S,Tatzelt J,Behl C,Kern A

更新日期：2017-05-06 00:00:00