Active transducin alpha subunit carries PDE6 to detergent-resistant membranes in rod photoreceptor outer segments.

abstract：:A major component of amyloid deposits found in Alzheimer disease and Down syndrome is the beta/A4 peptide, which is derived from the Alzheimer amyloid protein precursor (APP). Recent evidence indicates that increases in APP expression and/or beta/A4 peptide accumulation may underlie the amyloidosis characteristic of t...

journal_title：Biochemical and biophysical research communications

authors： Buxbaum JD,Christensen JL,Ruefli AA,Greengard P,Loring JF

更新日期：1993-12-15 00:00:00

abstract：:We examined voltage-dependent, TTX-resistant Na+ channels of newt retina (nRNaCh) electrophysiologically. IC50-TTX value of nRNaCh is more than 20 microM. We determined partial cDNA sequences of nRNaCh restricted to TTX binding sites (SS2 regions of all four repeats). While the amino acid sequences of SS2 regions of r...

journal_title：Biochemical and biophysical research communications

authors： Kaneko Y,Matsumoto G,Hanyu Y

更新日期：1997-11-26 00:00:00

abstract：:Intracellular symbiotic relationships are prevalent between cnidarians, such as corals and sea anemones, and the photosynthetic dinoflagellate symbionts. However, there is little understanding about how the genes express when the symbiotic relationship is set up. To characterize genes involved in this association, the...

journal_title：Biochemical and biophysical research communications

authors： Kuo J,Chen MC,Lin CH,Fang LS

更新日期：2004-05-21 00:00:00

abstract：:Metyrapone, an inhibitor of cytochrome P-450-dependent monooxygenases, enhanced the induction of tyrosine aminotransferase by dexamethasone in primary cultures of hepatocytes, while it had no effect on the basal level of the enzyme activity in the absence of the hormone. The amplification of the hormonal induction of ...

journal_title：Biochemical and biophysical research communications

authors： Tongiani R,Piazzolla S,Paolicchi A

更新日期：1990-01-30 00:00:00

abstract：:Manganese (Mn) is required in various human physiological processes. Excessive Mn exposure causes manganism, a progressive neurodegenerative disorder similar to idiopathic Parkinson's disease (IPD). However, the detailed mechanism of Mn-induced neurotoxicity is not yet fully understood. MicroRNAs (miRNAs) play importa...

journal_title：Biochemical and biophysical research communications

authors： He R,Xie X,Lv L,Huang Y,Xia X,Chen X,Zhang L

更新日期：2017-04-29 00:00:00

abstract：:Lanosterol was converted to a 14-demethylated metabolite, 4,4-dimethylzymosterol by Saccharomyces cerevisiae microsomes. This metabolism was mediated by a cytochrome P-450 (P-450/14DM). However, a reconstituted system consisting of P-450/14DM and its reductase converted lanosterol to the 14-desaturated derivative of 4...

journal_title：Biochemical and biophysical research communications

authors： Aoyama Y,Yoshida Y

更新日期：1986-01-29 00:00:00

abstract：:Two genes expressing 70 kDa heat shock proteins were identified in Cyprinus carpio. The sequence similarities and the intron-interrupted structure of the coding regions indicate that carp Hsc70-1 and Hsc70-2 belong to the Hsp70 cognate subfamily. The expressions of the two hsc70 genes were followed by semi-quantitativ...

journal_title：Biochemical and biophysical research communications

authors： Ali KS,Dorgai L,Abrahám M,Hermesz E

更新日期：2003-08-01 00:00:00

abstract：:Identification of TNF alpha receptors and their regulation by the endocrine system were examined in testicular Sertoli cells. By using cross-linking experiments as well as northern blotting analysis, we detected the p55 receptor type (MW: 55 kDa, mRNA: 2.3 kb), but not the p75 TNF alpha receptor type. Furthermore, we ...

journal_title：Biochemical and biophysical research communications

authors： Mauduit C,Besset V,Caussanel V,Benahmed M

更新日期：1996-07-25 00:00:00

abstract：:5'-RACE and genomic cloning were used to determine that the mouse TBP (mTBP) gene consists of one 5'-terminal non-coding exon followed by seven protein-coding exons. The region upstream of the first exon lacks a TATA-box. Hence, as with the case of other genes carrying TATA-less promoter, transcription starts from a c...

journal_title：Biochemical and biophysical research communications

authors： Ohbayashi T,Schmidt EE,Makino Y,Kishimoto T,Nabeshima Y,Muramatsu M,Tamura T

更新日期：1996-08-05 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been broadly used for tissue regeneration and repair due to their broad differentiation potential and potent paracrine properties such as angiogenic capacity. Strategies to increase their survival rate after transplantation and the angiogenic ability are of priority for the utility o...

journal_title：Biochemical and biophysical research communications

authors： Zhu Z,Gan X,Fan H,Yu H

更新日期：2015-12-25 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK) is one of the key protein kinases that regulate the growth and proliferation in cardiac fibroblasts (CFs). As an energy sensor of cellular metabolism, AMP-activated protein kinase (AMPK) is found recently to be involved in myocardial remodeling. In this study, we investigate...

journal_title：Biochemical and biophysical research communications

authors： Du J,Guan T,Zhang H,Xia Y,Liu F,Zhang Y

更新日期：2008-04-04 00:00:00

abstract：:Apoptosis is a mode of cell death characterized by chromatin condensation and disassembly of the nuclear lamina, processes that are also characteristic of mitosis. The apparent similarity between the two events, together with observations that apoptosis can occur following G2 arrest, has led to the suggestion that apo...

journal_title：Biochemical and biophysical research communications

authors： Norbury C,MacFarlane M,Fearnhead H,Cohen GM

更新日期：1994-08-15 00:00:00

abstract：:The organic anion and cation transporters (OATs and OCTs) are a large family (SLC22) of transmembrane proteins that are able to transport a variety of compounds including drugs, environmental toxins, and endogenous metabolites. OATs are expressed in various tissues, primarily kidney and liver, but also in placenta, sm...

journal_title：Biochemical and biophysical research communications

authors： Monte JC,Nagle MA,Eraly SA,Nigam SK

更新日期：2004-10-15 00:00:00

abstract：:In this study, we used four different cell lines, with or without presenilin-1 or -2, to investigate the hypothesis that the presence of presenilin, the most prominently mutated gene in Alzheimer's patients, affects the infection rate of host cells by Salmonella. The invasion and replication of Salmonella in presenili...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Kim HJ,Choy HE,Kim K

更新日期：2005-07-15 00:00:00

abstract：:In this study, we examined the effect of CLA isomers in preventing age-associated muscle loss and the mechanisms underlying this effect, using 12-months-old C57BL/6 mice fed 10% corn oil (CO) or a diet supplemented with 0.5% c9t11-CLA, t10c12-CLA, or c9t11-CLA+t10c12-CLA (CLA-mix) for 6months. Both t10c12-CLA and CLA-...

journal_title：Biochemical and biophysical research communications

authors： Rahman M,Halade GV,El Jamali A,Fernandes G

更新日期：2009-06-12 00:00:00

abstract：:The tumor suppressor, RASSF2 (Ras association domain family 2), is frequently downregulated in a number of cancers. Although exogenously expressed RASSF2 induces apoptotic cell death, the precise roles of RASSF2 under pro-apoptotic conditions remain largely unknown. Here, we demonstrate that MST1 (mammalian sterile 20...

journal_title：Biochemical and biophysical research communications

authors： Song H,Oh S,Oh HJ,Lim DS

更新日期：2010-01-01 00:00:00

abstract：:The organization of caveolae ultrastructures in the plasma membrane and the functions they dictate are mediated by membrane-embedded caveolins (caveolin-1, 2, 3) and peripherally attached cavins (cavin-1, 2, 3, 4). Mutations in caveolin and cavin genes are associated with a variety of human diseases. Cavin-1/PTRF muta...

journal_title：Biochemical and biophysical research communications

authors： Mohapatra A,Lokappa SB,Chaudhary N

更新日期：2020-01-15 00:00:00

abstract：:Efonidipine is a dual L-/T- type calcium channel blocker with a slow onset of action and a long lasting effect that exibihits antihypertensive and nephroprotective effects. differs from most other DHPs which can induce reflex tachycardia. Efonidipine reduces blood pressure without decreasing cardiac output and exerts ...

journal_title：Biochemical and biophysical research communications

authors： Xu F,Xiong W,Huang Y,Shen J,Zhou D,Tang L

更新日期：2019-06-04 00:00:00

abstract：:The present study shows for the first time that in proopiomelanocortin cells of the rat intermediate pituitary gland ANF binds to two receptor forms, with apparent molecular weights of 150K and 70K. Scatchard plots revealed specific and high affinity non-interacting sites, with a KD value of about 3 nM and a density o...

journal_title：Biochemical and biophysical research communications

authors： Lutz-Bucher B,Boudjada T,Heisler S,Pelletier G,Koch B

更新日期：1988-08-30 00:00:00

abstract：:Adeno-associated virus (AAV) capsids are composed of three proteins, VP1, VP2, and VP3. These capsid proteins have a common amino acid sequence, being expressed from different initiation codons on the same open reading frame. Although VP1 is necessary for viral infection, it is not essential for capsid formation. The ...

journal_title：Biochemical and biophysical research communications

authors： Hoque M,Shimizu N,Ishizu Ki,Yajima H,Arisaka F,Suzuki K,Watanabe H,Handa H

更新日期：1999-12-20 00:00:00

abstract：:The adeno-associated virus site 1 (AAVS1) locus in the human genome is a strong candidate for gene therapy by insertion of an exogenous gene into the locus. The AAVS1 locus includes the coding region for myosin binding subunit 85 (MBS85). Although the function of MBS85 is not well understood, myosin II-dependent contr...

journal_title：Biochemical and biophysical research communications

authors： Mizutani T,Li R,Haga H,Kawabata K

更新日期：2015-09-18 00:00:00

abstract：:The efp, a member of the RING finger family, was previously identified as an estrogen responsive gene. Here, we characterized basal promoter of the human efp gene. Transcription initiation site was found at position -60 G relative to the site for translation initiation, and TATA motif was absent. Deletion and mutation...

journal_title：Biochemical and biophysical research communications

authors： Ikeda K,Inoue S,Orimo A,Sano M,Watanabe T,Tsutsumi K,Muramatsu M

更新日期：1997-07-30 00:00:00

abstract：:Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-related death for both men and women. Recent studies have revealed that a small sub-population of cancer cells, termed cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), are endowed with tumor-initiati...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Hirohashi Y,Ogawa T,Shen M,Takeda R,Murai A,Yamamoto E,Kubo T,Nakatsugawa M,Kanaseki T,Tsukahara T,Nishidate T,Okita K,Kutomi G,Sato N,Takemasa I,Torigoe T

更新日期：2017-04-29 00:00:00

abstract：:Using a highly sensitive RT-PCR technique that measures mRNA (cDNA)-to-DNA ratios, we are able to detect constitutive CYP1A1 mRNA in adult mouse liver as well as in the oocyte. Twelve hours after fertilization of the ovum, there is a more than 100-fold increase in constitutive CYP1A1 mRNA levels; this dramatic increas...

journal_title：Biochemical and biophysical research communications

authors： Dey A,Nebert DW

更新日期：1998-10-20 00:00:00

abstract：:Above pH 6, swine pepsin undergoes a conformational change to a neutral form which has 80% of the secondary structure of the native protein. In contrast to native pepsin, this form of the enzyme can be reversibly unfolded by urea in a rapid, cooperative reaction. Since all of pepsin's sequence is present in its precur...

journal_title：Biochemical and biophysical research communications

authors： McPhie P

更新日期：1989-01-16 00:00:00

abstract：:In the TT cell line of human medullary thyroid carcinoma, the viral Harvey ras (v-rasH) oncogene induces differentiation, marked by morphological changes, diminution of growth, and increased expression of the calcitonin gene. Here, we show that the transcriptional factor c-jun is increased during v-rasH induced differ...

journal_title：Biochemical and biophysical research communications

authors： Nelkin BD,Borges M,Mabry M,Baylin SB

更新日期：1990-07-16 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is involved in DNA repair and activated by DNA damage. When activated, PARP-1 consumes NAD(+) to form ADP-ribose polymers on acceptor proteins. Extensive activation of PARP-1 leads to glycolytic blockade, energy failure, and cell death. These events have ...

journal_title：Biochemical and biophysical research communications

authors： Ying W,Garnier P,Swanson RA

更新日期：2003-09-05 00:00:00

abstract：:The Rpb4/7 subcomplex of RNA polymerase II in Saccharomyces cerevisiae is known to play an important role in stress response and stress survival. These two proteins perform overlapping functions ensuring an appropriate cellular response through transcriptional regulation of gene expression. Rpb4 and Rpb7 also perform ...

journal_title：Biochemical and biophysical research communications

authors： Singh SR,Pillai B,Balakrishnan B,Naorem A,Sadhale PP

更新日期：2007-04-27 00:00:00

abstract：:We have identified two types of homologous DNA pairing activity in mouse cell extracts by a strand-transfer assay. Both activities are separated from each other by anion-exchange chromatography; neither of them needs ATP. One requires magnesium ion and is stimulated by Escherichia coli single-stranded DNA binding prot...

journal_title：Biochemical and biophysical research communications

authors： Mishina Y,Shimokawa T,Kawasaki K,Arai N,Shibata T,Koyama H

更新日期：1992-06-30 00:00:00

abstract：:The purpose of this study was to examine whether mechanical tensile forces affect estrogen regulation of collagen synthesis of anterior cruciate ligament fibroblasts at the mRNA level. Estrogen was studied at three physiologic levels, 10(-11), 10(-10), and 10(-9)M. The results revealed that estrogen alone stimulated T...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Smith CL,Zhang X,Hsu HC,Wang DY,Luo ZP

更新日期：2004-05-14 00:00:00