Mechanical stretch endows mesenchymal stem cells stronger angiogenic and anti-apoptotic capacities via NFκB activation.

abstract：:In Wernicke's encephalopathy and thiamine deficiency (TD), the cause of this brain disorder, development of inflammation is an important aspect of the disease process. How this pathological mechanism relates to the neurologic impairment associated with TD, however, remains unclear. A key feature of the inflammatory pr...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Hazell AS

更新日期：2010-11-05 00:00:00

abstract：:Serum leptin levels are elevated in subjects with exogenous obesity, indicating that obesity is associated with leptin resistance. Since in man no abnormalities have yet been found in either the genes for leptin or its receptor, the mechanism of leptin resistance in obesity remains unknown. To determine if resistance ...

journal_title：Biochemical and biophysical research communications

authors： Diamond FB Jr,Eichler DC,Duckett G,Jorgensen EV,Shulman D,Root AW

更新日期：1997-04-28 00:00:00

abstract：:Previous results from our laboratory showed that an increase in the nonpolar alkyl chain length in tetraalkylammonium cations is accompanied by greater efficiency in driving the B-to-Z transition. Analogous effects are observed when the hydrocarbon portion of carboxylate anions and alcohols is increased in size. The m...

journal_title：Biochemical and biophysical research communications

authors： McDonnell NB,Preisler RS

更新日期：1989-10-16 00:00:00

abstract：:Nucleophosmin (NPM) is a multifunctional nucleolar protein that has been linked with nucleolar stress. In non-neuronal cell lines, NPM may enhance or inhibit the activity of tumor suppressor p53, a major apoptotic protein. The relationship between NPM and p53 in the central nervous system (CNS) remains unknown. Here, ...

journal_title：Biochemical and biophysical research communications

authors： Marquez-Lona EM,Tan Z,Schreiber SS

更新日期：2012-01-06 00:00:00

abstract：:Lactoferrin (LF) is a multifunctional, iron-binding glycoprotein in mammalian secretions, such as breast milk, and has several beneficial effects for human health. However, how these effects are exerted at the cellular level is still largely unknown. In this study, we investigated the effects of LF on autophagy activi...

journal_title：Biochemical and biophysical research communications

authors： Aizawa S,Hoki M,Yamamuro Y

更新日期：2017-11-04 00:00:00

abstract：:A melanin (melanosome) concentrating hormone, MCH, was synthesized and the methodology for its synthesis is detailed. This heptadecapeptide, H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH , stimulated melanosome concentration (centripetal aggregation) within melanophores of all species of tel...

journal_title：Biochemical and biophysical research communications

authors： Wilkes BC,Hruby VJ,Sherbrooke WC,Castrucci AM,Hadley ME

更新日期：1984-07-31 00:00:00

abstract：:Here we describe differences in the formation of the epinephrine-induced Ca2+ transients between parent and Ki-ras-transformed NIH3T3 fibroblasts. These transients proved to be the results of an efflux from both the thapsigargin-sensitive and -insensitive intracellular pools. While the epinephrine-induced detachment o...

journal_title：Biochemical and biophysical research communications

authors： Tóth S,Fu T,Nozawa Y,Csaba G

更新日期：1993-01-29 00:00:00

abstract：:ATP-binding cassette transporter D2 (D2) is an ABC half transporter that is thought to promote the transport of very long-chain fatty acyl-CoAs into peroxisomes. Both D2 and peroxisomes increase during adipogenesis. Although peroxisomes are essential to both catabolic and anabolic lipid metabolism, their function, and...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Liu J,Lester JD,Pijut SS,Graf GA

更新日期：2015-01-02 00:00:00

abstract：:A voltage-dependent K+ current has been revealed in whole-cell recordings carried out on immortalized cells obtained from the human tracheal epithelium. At positive membrane potentials the current shows a time dependent inactivation which is accelerated by increasing the depolarizing step. Forskolin, a direct activato...

journal_title：Biochemical and biophysical research communications

authors： Galietta LJ,Rasola A,Barone V,Gruenert DC,Romeo G

更新日期：1991-09-30 00:00:00

abstract：:It is widely considered that it is not appropriate to treat beta-pairs in isolation, since other secondary structural models (such as helices, coils), protein topology and protein tertiary structures would limit beta-strand pairing. However, to understand the underlying mechanisms of beta-sheet formation, studies ough...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Ruan J,Duan G,Gao S,Zhang T

更新日期：2009-08-28 00:00:00

abstract：:In mammals, behavioral and physiological processes display 24-h rhythms that are regulated by a circadian system. In the present study, we investigated the possibility that the expression of clock genes in peripheral leukocytes can be used to assess the circadian clock system. We found that Per1 and Per2 exhibit circa...

journal_title：Biochemical and biophysical research communications

authors： Fukuya H,Emoto N,Nonaka H,Yagita K,Okamura H,Yokoyama M

更新日期：2007-03-23 00:00:00

abstract：:The induction of human BiP/GRP78 and GAPDH protein genes by the calcium ionophore A23187 was determined. Steady-state levels of mRNA for both the glucose starvation-responsive BiP/GRP78 gene and the glucose-responsive GAPDH gene were dramatically induced in a variety of human cells. There is a homologous palindromatic...

journal_title：Biochemical and biophysical research communications

authors： Chao CC,Yam WC,Lin-Chao S

更新日期：1990-08-31 00:00:00

abstract：:Two P-450s from adult pig testis were purified to specific contents of 11.2 and 12.0 nmol P-450/mg protein and shown to have minimum molecular weights of 45,000 and 46,000, respectively. The absorption spectra were typical of P-450s. The P-450s were separated from the two fractions by CM-C50 Sephadex column chromatogr...

journal_title：Biochemical and biophysical research communications

authors： Kuwada M,Takizawa N,Sone Y

更新日期：1996-01-17 00:00:00

abstract：:The Frizzled-type cysteine-rich domain (CRD) is a binding motif for soluble-type glycoprotein WNTs, which play key roles in embryogenesis and carcinogenesis. Here, we have cloned and characterized a novel gene MFRP, encoding a type II transmembrane protein with CRD. In addition to CRD, two tandem-repeats containing th...

journal_title：Biochemical and biophysical research communications

authors： Katoh M

更新日期：2001-03-23 00:00:00

abstract：:Antisense oligonucleotides were modified by their ends with hydrophobic substituents which permitted enhancing their activity. The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the sp...

journal_title：Biochemical and biophysical research communications

authors： Vinogradov SV,Suzdaltseva Y,Alakhov VYu,Kabanov AV

更新日期：1994-09-15 00:00:00

abstract：:Epitopic peptides representing the C-terminal (HA1) region of cleaved hemagglutinin of influenza virus from different serotypes were synthesized. Circular dichroism and Fourier-transform infrared spectroscopic data showed that peptides HS2 and HS3 have a predominantly alpha-helical conformation in trifluoroethanol. Re...

journal_title：Biochemical and biophysical research communications

authors： Holly S,Majer Z,Tóth GK,Váradi G,Rajnavölgyi E,Laczkó I,Hollósi M

更新日期：1993-06-30 00:00:00

abstract：:Voltage-gated ion channels (VGCs) mediate selective diffusion of ions across cell membranes to enable many vital cellular processes. Three-dimensional structure data are lacking for VGC proteins; hence, to better understand their function, there is a need to identify the conserved motifs using sequence analysis method...

journal_title：Biochemical and biophysical research communications

authors： Guda P,Bourne PE,Guda C

更新日期：2007-01-12 00:00:00

abstract：:CH31 B lymphomas represent a model for antigen-induced deletional tolerance of immature B lymphocytes, because cross-linking the B cell antigen receptor (BCR) induces G(1) phase arrest and apoptosis. We have recently demonstrated that BCR cross-linking leads to a transient activation of p38 mitogen-activated protein k...

journal_title：Biochemical and biophysical research communications

authors： Swart JM,Chiles TC

更新日期：2000-09-24 00:00:00

abstract：:The profile of primary dioxygenation products of arachidonic acid catalyzed by lipoxygenase isolated from hairy root cultures of Solanum tuberosum treated with a fungal elicitor was compared to that obtained for the enzyme from potato tubers. 11-Hydroperoxyeicosatetraenoic acid (11-HPETE) was the most abundant dioxyge...

journal_title：Biochemical and biophysical research communications

authors： Reddy GR,Reddanna P,Reddy CC,Curtis WR

更新日期：1992-12-30 00:00:00

abstract：:P-selectin (CD62P) is a cell adhesion molecule expressed on stimulated endothelial cells and on activated platelets. It interacts with PSGL-1 (P-selectin glycoprotein ligand-1; CD162) on leukocytes and mediates recruitment of leukocytes during inflammation. P-selectin also binds to several types of cancer cells in vit...

journal_title：Biochemical and biophysical research communications

authors： Li L,Short HJ,Qian KX,Elhammer AP,Geng JG

更新日期：2001-11-02 00:00:00

abstract：:A single nucleotide polymorphism (SNP) resulting in a substitution from Gln to His was found in exon 4 of the CYP2B6 gene in Japanese. The frequency of the variant allele was found to be 19.9%. The mutant- and the wild-type enzymes were expressed in Escherichia coli, and the effects of the single amino acid substituti...

journal_title：Biochemical and biophysical research communications

authors： Ariyoshi N,Miyazaki M,Toide K,Sawamura Yi,Kamataki T

更新日期：2001-03-01 00:00:00

abstract：:Oriented fibers of DNA, prepared by the wet spin method, were imaged by atomic force microscopy. It was found that an oriented fiber's substructure is an array of assemblages of DNA. For native DNA, the assemblages exhibit a characteristic width of 76 nm, a thickness of 20 nm, and appear to carry a right handed twist....

journal_title：Biochemical and biophysical research communications

authors： Rampino NJ

更新日期：1992-01-15 00:00:00

abstract：:Endothelial growth factors have become the target of intense research since the initial discovery of vascular endothelial growth factor (VEGF/VPF). At present, VEGF is established as a major inducer of angiogenesis in normal and pathological conditions. Recently several new members in the VEGF family have been describ...

journal_title：Biochemical and biophysical research communications

authors： Farnebo F,Piehl F,Lagercrantz J

更新日期：1999-04-21 00:00:00

abstract：:Picrotoxin is a CYP2B inducer in mammals (1). However, in primary cultures of rainbow trout hepatocytes we showed CYP1A1 gene expression to be strongly induced as characterized by 7-ethoxyresorufin-O-deethylase activity, immunoblots of CYP1A1 protein, and Northern blots of CYP1A1 mRNA. Induction of CYP1A1 in these cel...

journal_title：Biochemical and biophysical research communications

authors： Sadar MD,Ash R,Andersson TB

更新日期：1995-09-25 00:00:00

abstract：:The effect of blue background light on behavioral response of Halobacterium halobium to step-like stimulation with green-orange attractant light was examined. The results strongly support the previously proposed hypothesis that a long-lifetime photointermediate of s-rhodopsin is the photoreceptor for repellent light: ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi T,Mochizuki Y,Kamo N,Kobatake Y

更新日期：1985-02-28 00:00:00

abstract：:HSP60 has been proved to be closely related to atherosclerosis due to its antigenicity. To determine this antigenicity effect, the ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously (SC) for potential vaccine against atherosclerosis. Here, we observed the ApoE-/- mice wit...

journal_title：Biochemical and biophysical research communications

authors： Hu Y,Chen Z,Jiang L,Chen F,Jin R,Cheng L

更新日期：2018-04-15 00:00:00

abstract：:Isoprenoids comprise a diverse group of natural products with a broad range of metabolic functions. Isoprenoids are synthesized from prenyl pyrophosphates by prenyltransferases that catalyze the isoprenoid chain-elongation process to different chain lengths. We hereby present the crystal structure of geranylgeranyl py...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Kim EJ,Park JB,Kim SW,Kim KJ

更新日期：2019-10-20 00:00:00

abstract：:The developing and the adult brain respond in similar ways to ischemia, but also display clear differences. For example, the relative contributions of necrosis and apoptosis to neuronal death may be different, such that apoptotic mechanisms would be more prevalent in the developing brain. During normal development, mo...

journal_title：Biochemical and biophysical research communications

authors： Blomgren K,Zhu C,Hallin U,Hagberg H

更新日期：2003-05-09 00:00:00

abstract：:We investigated the effects of neuropeptide Y on the prostacyclin production of cultured porcine aortic endothelial cells by measuring the stable metabolite of prostacyclin, 6-keto-prostaglandin F1 alpha, by radioimmunoassay. Neuropeptide Y induced dose- and time-dependent stimulation of prostacyclin production by cul...

journal_title：Biochemical and biophysical research communications

authors： Kawamura K,Smith TL,Zhou Q,Kummerow FA

更新日期：1991-08-30 00:00:00

abstract：:Plants are often exposed not only to short-term (S-) heat stress but also to diurnal long-term (L-) heat stress over several consecutive days; nevertheless, most previous studies of heat tolerance have used S-heat stress, such as 42 °C for 30-60 min, for evaluation. Yet the mechanisms underlying L-heat tolerance remai...

journal_title：Biochemical and biophysical research communications

authors： Ono M,Isono K,Sakata Y,Taji T

更新日期：2021-01-01 00:00:00