Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL.

Abstract:

:The purpose of this study was to examine whether mechanical tensile forces affect estrogen regulation of collagen synthesis of anterior cruciate ligament fibroblasts at the mRNA level. Estrogen was studied at three physiologic levels, 10(-11), 10(-10), and 10(-9)M. The results revealed that estrogen alone stimulated Type I and III collagen synthesis at the mRNA level, and application of mechanical force decreased the expression of collagen Type I and III genes at all tested estrogen levels. These findings suggest that estrogen may directly regulate ligament structure and function by alteration of Type I and III collagen synthesis. This regulation is dependent on mechanical loading.

authors

Lee CY,Smith CL,Zhang X,Hsu HC,Wang DY,Luo ZP

doi

10.1016/j.bbrc.2004.03.174

subject

Has Abstract

pub_date

2004-05-14 00:00:00

pages

1221-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X0400693X

journal_volume

317

pub_type

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