Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity.

abstract：:A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to th...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Matsuo H

更新日期：1984-07-31 00:00:00

abstract：:We have isolated a rabbit metallothionein-I gene from a lambda gt10 library. The coding sequence of this gene is interrupted by two introns occurring at amino acid positions 9 1/3 and 30 1/3. Comparison of the promoter sequence of this gene with the promoters of other metallothionein genes identified a number of oligo...

journal_title：Biochemical and biophysical research communications

authors： Tam YC,Chopra A,Hassan M,Thirion JP

更新日期：1988-05-31 00:00:00

abstract：:A number of cyclohexenyl chalcone Diels-Alder natural products possess promising biological properties including strong cytotoxicity in various human cancer cells. Herein, we show that natural products in this class including panduratin A and nicolaioidesin C inhibit cysteine cathepsins as indicated by protease profil...

journal_title：Biochemical and biophysical research communications

authors： Deb Majumdar I,Devanabanda A,Fox B,Schwartzman J,Cong H,Porco JA Jr,Weber HC

更新日期：2011-12-16 00:00:00

abstract：:The discovery of small molecule kinase inhibitors for use as drugs is a promising approach for the treatment of cancer and other diseases, but the discovery of highly specific agents is challenging because over 850 kinases are expressed in mammalian cells. Systematic modification of the 4-anilino functionality of a se...

journal_title：Biochemical and biophysical research communications

authors： Bhattacharya SK,Cox ED,Kath JC,Mathiowetz AM,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Richter DT,Su C,Wessel MD

更新日期：2003-07-25 00:00:00

abstract：:The effect of endothelin-1 (ET-1) on secretion and synthesis of rat atrial natriuretic peptide (rANP) as well as its mRNA levels was studied in primary cultures of neonatal rat atrial cardiocytes. ET-1 dose-dependently (10(-10)-10(-7) M) increased media and cellular rANP-like immunoreactivity as well as its cytoplasmi...

journal_title：Biochemical and biophysical research communications

authors： Fukuda Y,Hirata Y,Taketani S,Kojima T,Oikawa S,Nakazato H,Kobayashi Y

更新日期：1989-11-15 00:00:00

abstract：:The prion diseases are neurodegenerative disorders characterized by the conversion of the PrPc (normal cellular prion) to the PrPsc (misfolded isoform). The accumulation of PrPsc within the central nervous system (CNS) leads to neurocytotoxicity by increasing oxidative stress. In addition, many neurodegenerative disor...

journal_title：Biochemical and biophysical research communications

authors： Jeong JK,Seol JW,Moon MH,Seo JS,Lee YJ,Kim JS,Park SY

更新日期：2010-10-29 00:00:00

abstract：:Recombinant human OP-1 stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) significantly and in a dose-dependent manner in rat bone marrow cell culture. Newly formed MNCs either induced by hOP-1 alone or with 1,25(OH)2D3 were also positive for vitronectin recepto...

journal_title：Biochemical and biophysical research communications

authors： Hentunen TA,Lakkakorpi PT,Tuukkanen J,Lehenkari PP,Sampath TK,Väänänen HK

更新日期：1995-04-17 00:00:00

abstract：:The MoFe protein of the complex metalloenzyme nitrogenase folds as a heterotetramer containing two copies each of the homologous alpha and beta subunits, encoded by the nifD and the nifK genes respectively. Recently, the functional expression of a fusion NifD-K protein of nitrogenase was demonstrated in Azotobacter vi...

journal_title：Biochemical and biophysical research communications

authors： Lahiri S,Pulakat L,Gavini N

更新日期：2005-11-18 00:00:00

abstract：:Cigarette smoke is a major cause of chronic obstructive pulmonary disease (COPD). Circular RNAs (circRNAs) are involved in regulating various biological processes. This study aimed to explore the role and molecular basis of hsa_circ_0006872 in cigarette smoke extract (CSE)-induced cell injury. HPMECs and BEAS-2B cells...

journal_title：Biochemical and biophysical research communications

authors： Xue M,Peng N,Zhu X,Zhang H

更新日期：2021-01-01 00:00:00

abstract：:This study examined the actions of L-arginine, a putative precursor of endothelium-derived nitric oxide, and arginine analogs on endothelium-dependent relaxation of isolated rings of bovine pulmonary artery. L-Arginine did not consistently relax arterial rings unless rings were first rendered refractory to endothelium...

journal_title：Biochemical and biophysical research communications

authors： Gold ME,Wood KS,Buga GM,Byrns RE,Ignarro LJ

更新日期：1989-06-15 00:00:00

abstract：:The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase gamma, a Mg2+/Ca2+-dependent endonuclease, has been suggested to be one of the apoptotic endonucleases, but its biochemical characteristic has not been fully elucidated. Here, using recombinant DNase gamma, we showed that DNase ...

journal_title：Biochemical and biophysical research communications

authors： Mizuta R,Mizuta M,Araki S,Shiokawa D,Tanuma S,Kitamura D

更新日期：2006-06-30 00:00:00

abstract：:Cyclooxygenase 2 (COX)-2 is induced by bacterial and viral infections and has complex, poorly understood roles in anti-pathogen immunity. Here, we use a knock-in luciferase reporter model to image Cox2 expression across a range of tissues in mice following treatment with the either the prototypical bacterial pathogen-...

journal_title：Biochemical and biophysical research communications

authors： Kirkby NS,Zaiss AK,Wright WR,Jiao J,Chan MV,Warner TD,Herschman HR,Mitchell JA

更新日期：2013-08-23 00:00:00

abstract：:Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microg...

journal_title：Biochemical and biophysical research communications

authors： Gejyo F,Yamada T,Odani S,Nakagawa Y,Arakawa M,Kunitomo T,Kataoka H,Suzuki M,Hirasawa Y,Shirahama T

更新日期：1985-06-28 00:00:00

abstract：:Microfilaments play an important role in the formation of apoptotic bodies. This study examined expression patterns of beta-actin, a key component of microfilament, during apoptosis. The data suggest that continuous beta-actin expression is not required for formation of apoptotic bodies. beta-actin mRNA levels rapidly...

journal_title：Biochemical and biophysical research communications

authors： Naora H,Naora H

更新日期：1995-06-15 00:00:00

abstract：:The presence of type I transglutaminase was determined in the neoplastic human keratinocyte line SqCC/Y1 and in normal human epidermal keratinocytes (NHEK) by an in situ radioimmunoassay which corresponded directly with the measurement of type I transglutaminase enzymatic activity. Dexamethasone induced differentiatio...

journal_title：Biochemical and biophysical research communications

authors： Moore KG,Donadio AC,Sartorelli AC

更新日期：1993-04-30 00:00:00

abstract：:We have examined the kinetics of the effects of inhibitors of the Na+/H(+)-antiporter (dimethylamiloride) and the vacuolar H(+)-ATPase (bafilomycin A1) on bone resorption by disaggregated rat osteoclasts in the bone slice assay. Bafilomycin A1 (100 nM) inhibited resorption by approximately 95%, 75%, 80% and 60% respec...

journal_title：Biochemical and biophysical research communications

authors： Hall TJ,Schaeublin M,Chambers TJ

更新日期：1992-11-16 00:00:00

abstract：:The proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli is composed of two types of subunits, alpha and beta, organized as an alpha(2)beta(2) tetramer. The protein contains three recognizable domains, of which domain II is the transmembrane region of the molecule containing the pathway for pr...

journal_title：Biochemical and biophysical research communications

authors： Hou C,Bragg PD

更新日期：2001-01-19 00:00:00

abstract：:Expression of TNF-alpha gene in the retinal pigment epithelial (RPE) cells was studied by using polymerase chain reaction (PCR). PCR for human TNF-alpha gene using complementary DNA (cDNA) of control RNA prepared from non-stimulated RPE cells failed to show expression of TNF-alpha gene. However, PCR by using cDNA prep...

journal_title：Biochemical and biophysical research communications

authors： Tanihara H,Yoshida M,Yoshimura N

更新日期：1992-09-16 00:00:00

abstract：:Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction was [Val5]-angiotensin II, a...

journal_title：Biochemical and biophysical research communications

authors： Kaneko S,Tamura S,Takagi H

更新日期：1985-01-16 00:00:00

abstract：:Numerous phytochemicals are believed to have beneficial effects on human health. N-Coumaroyltyramine accumulates in plants in response to wounding and pathogen attack. Due to the scarcity of N-coumaroyltyramine, its biological activities have not been studied in human cells. In this study, N-coumaroyltyramine was chem...

journal_title：Biochemical and biophysical research communications

authors： Park JB,Schoene N

更新日期：2002-04-12 00:00:00

abstract：:The effects of anadamide, 2-arachidonoylglycerol and related compounds on the specific binding of a radiolabeled cannabinoid receptor ligand,[3H]CP55940, to synaptosomal membranes were examined. Anandamide, an endogenous cannabinoid receptor ligand, reduced the specific binding of [3H]CP55940 to synaptosomal membranes...

journal_title：Biochemical and biophysical research communications

authors： Sugiura T,Kondo S,Sukagawa A,Nakane S,Shinoda A,Itoh K,Yamashita A,Waku K

更新日期：1995-10-04 00:00:00

abstract：:The estrogen receptor (ER) is a ligand-dependent transcription factor which regulates growth, development, differentiation and reproduction. To test the hypothesis that the diverse effects of the ER could be mediated by interacting with other transcription factors/oncogenes, the present study assessed its interaction ...

journal_title：Biochemical and biophysical research communications

authors： Yu CL,Driggers P,Barrera-Hernandez G,Nunez SB,Segars JH,Cheng S

更新日期：1997-10-20 00:00:00

abstract：:The induction of human BiP/GRP78 and GAPDH protein genes by the calcium ionophore A23187 was determined. Steady-state levels of mRNA for both the glucose starvation-responsive BiP/GRP78 gene and the glucose-responsive GAPDH gene were dramatically induced in a variety of human cells. There is a homologous palindromatic...

journal_title：Biochemical and biophysical research communications

authors： Chao CC,Yam WC,Lin-Chao S

更新日期：1990-08-31 00:00:00

abstract：:Integrins are a family of cell surface adhesion molecules which mediate cell adhesion and initiate signaling pathways that regulate cell spreading, migration, differentiation, and proliferation. TGF-beta is a multifunctional factor that induces a wide variety of cellular processes. In this study, we show that, TGF-bet...

journal_title：Biochemical and biophysical research communications

authors： Cai T,Lei QY,Wang LY,Zha XL

更新日期：2000-08-02 00:00:00

abstract：:Hepatic fibrosis can be considered as wound healing process in response to hepatocellular injury. Activation of hepatic stellate cells (HSCs) is a key event of hepatic fibrosis since activated HSCs are the cellular source of enhanced extracellular matrix deposition, and reversion of liver fibrosis is accompanied by cl...

journal_title：Biochemical and biophysical research communications

authors： Valletta D,Czech B,Thasler WE,Müller M,Bosserhoff AK,Hellerbrand C

更新日期：2012-09-28 00:00:00

abstract：:The ubiquitous eukaryotic protein kinase CKII (casein kinase II) has been found to interact with a number of cellular proteins, either through the catalytic subunit or the regulatory subunit. Using the yeast two-hybrid screening method, we found that the catalytic subunit of Drosophila melanogaster CKII (DmCKII) inter...

journal_title：Biochemical and biophysical research communications

authors： Zhao W,Bidwai AP,Glover CV

更新日期：2002-10-18 00:00:00

abstract：:Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity ...

journal_title：Biochemical and biophysical research communications

authors： Garcia RL,Schilling WP

更新日期：1997-10-09 00:00:00

abstract：AIM:To investigate the effect of endogenous PTH deficiency on osteoclasts during fracture healing and its mechanism. METHODS:A femoral fracture model was used to determine the role of endogenous PTH in fracture healing. Immunohistochemistry, qPCR, and Western blot were used to determine the potential functions and mec...

journal_title：Biochemical and biophysical research communications

authors： Sun P,Wang M,Yin GY

更新日期：2020-05-14 00:00:00

abstract：:Hyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastri...

journal_title：Biochemical and biophysical research communications

authors： Wu WK,Sung JJ,Yu L,Li ZJ,Chu KM,Cho CH

更新日期：2008-08-22 00:00:00

abstract：:We here report that aging increases expression of endothelin-1 and NO synthases in the vasculature and kidney of normotensive rats in vivo. Expression of preproendothelin-1 mRNA was quantified by RT-PCR and in situ hybridization, and endothelin-1 protein was determined by radioimmunoassay/HPLC. Vascular mRNA expressio...

journal_title：Biochemical and biophysical research communications

authors： Goettsch W,Lattmann T,Amann K,Szibor M,Morawietz H,Münter K,Müller SP,Shaw S,Barton M

更新日期：2001-01-26 00:00:00