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Deficient repair of 8-hydroxyguanine in the BxPC-3 pancreatic cancer cell line.

Abstract：

:Elevated levels of oxidatively induced DNA lesions have been reported in malignant pancreatic tissues relative to normal pancreatic tissues. However, the ability of the pancreatic cancer cells to remove these lesions has not previously been addressed. This study analyzed the effectiveness of the pancreatic cancer cell line, BxPC-3 to repair 8-hydroxyguanine (8-OH-Gua) relative to a nonmalignant cell line. We show that BxPC-3 cells repair 8-OH-Gua less effectively than the nonmalignant cells. This repair deficiency correlated with significant downregulation of the hOGG1 protein and the corresponding mRNA (30-fold lower than GAPDH) in BxPC-3 cell line. The repair defect was complemented in vivo by transient transfection of the hOGG1 gene and in vivo by recombinant hOGG1. These results are the first to show a deficiency of 8-OH-Gua repair in BxPC-3 cells, implicating this defect in the risk factor of pancreatic cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nyaga SG,Lohani A,Evans MK

doi

10.1016/j.bbrc.2008.08.134

subject

Has Abstract

pub_date

2008-11-14 00:00:00

pages

336-40

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01699-9

journal_volume

376

pub_type

杂志文章

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