Fluorogenic peptides containing only alpha-amino acids.

abstract：:Distribution of mRNA expression of 1,25-dihydroxyvitamin D3 receptor (VDR) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase) along the microdissected rat nephron segments was examined by reverse transcription-polymerase chain reaction (RT-PCR) technique. VDR mRNA was abundantly expressed in cortical segments (glomeru...

journal_title：Biochemical and biophysical research communications

authors： Iida K,Taniguchi S,Kurokawa K

更新日期：1993-07-30 00:00:00

abstract：:On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supple...

journal_title：Biochemical and biophysical research communications

authors： Koch OR,De Leo ME,Borrello S,Palombini G,Galeotti T

更新日期：1994-06-30 00:00:00

abstract：:The replication of human mitochondrial DNA (mtDNA) is initiated from a pair of displaced origins, one priming continuous synthesis of daughter-strand DNA from the heavy strand (OH) and the other priming continuous synthesis from the light strand (OL). In patients with sporadic large-scale rearrangements of mitochondri...

journal_title：Biochemical and biophysical research communications

authors： Umeda S,Tang Y,Okamoto M,Hamasaki N,Schon EA,Kang D

更新日期：2001-08-31 00:00:00

abstract：:The function of His159 in the enolase mechanism is disputed. Recently, Vinarov and Nowak (Biochemistry (1999) 38, 12138-12149) prepared the H159A mutant of yeast enolase 1 and expressed this in Escherichia coli. They reported minimal (ca. 0.01% of the native value) activity, though the protein appeared to be correctly...

journal_title：Biochemical and biophysical research communications

authors： Brewer JM,Holland MJ,Lebioda L

更新日期：2000-10-05 00:00:00

abstract：:Studies of islet neogenesis have suggested that the regeneration of islet cells can be achieved through redifferentiation of pre-existing islet cells. However, this hypothesis is largely unproven and fails to account for the diversity of observed islet neogenesis. Here we show that cultured neonatal pancreatic cells d...

journal_title：Biochemical and biophysical research communications

authors： Zhao W,Hirose T,Ishikawa M,Oshima Y,Hirai S,Ohno S,Taniguchi H

更新日期：2007-01-05 00:00:00

abstract：:We used a lactose-substituted polystyrene, poly-N-p-vinylbenzyl-D-lactonamide (PVLA), as a substratum for adult rat hepatocytes in primary culture. Spherical-shaped hepatocytes attached on PVLA substratum formed stable multilayer aggregates anchored on substratum through the stimulation of epidermal growth factor (EGF...

journal_title：Biochemical and biophysical research communications

authors： Tobe S,Takei Y,Kobayashi K,Akaike T

更新日期：1992-04-15 00:00:00

abstract：:Narcan, the pharmaceutical agent for the administration of naloxone, has been reported to antagonize ethanol intoxication. In addition to naloxone, Narcan contains the antioxidant esters methyl- and propylparaben. Pure naloxone and these two esters were examined for their capacity to inhibit ethanol oxidation by purif...

journal_title：Biochemical and biophysical research communications

authors： Dingley AL,Holmquist B,Vallee BL

更新日期：1985-08-30 00:00:00

abstract：:Runt-related transcription factor 2 (Runx2), also known as core binding factor 1 (Cbfa1), is a multifunctional transcription factor and an essential master gene controlling osteoblast differentiation. We previously demonstrated the in vivo functions of Runx2 in mesoderm-derived cells. However, no studies have been con...

journal_title：Biochemical and biophysical research communications

authors： Shirai Y,Kawabe K,Tosa I,Tsukamoto S,Yamada D,Takarada T

更新日期：2019-02-19 00:00:00

abstract：:In many apoptotic cells, phosphatidylserine (PS), that is normally restricted to the inner membrane layer, is externalized and subsequently recognized by phagocytes. However, it has been unclear whether PS externalization is sufficient for phagocytosis induction. In a cultured cell line undergoing Fas-mediated apoptos...

journal_title：Biochemical and biophysical research communications

authors： Shiratsuchi A,Osada S,Kanazawa S,Nakanishi Y

更新日期：1998-05-19 00:00:00

abstract：:To better understand the mechanism of interactions between G-protein-coupled melatonin receptors and their ligands, our previously reported homology model of human MT2 receptor with docked 2-iodomelatonin was further refined and used to select residues within TM3, TM6, and TM7 potentially important for receptor-ligand...

journal_title：Biochemical and biophysical research communications

authors： Mazna P,Berka K,Jelinkova I,Balik A,Svoboda P,Obsilova V,Obsil T,Teisinger J

更新日期：2005-07-08 00:00:00

abstract：:A Bacillus thuringiensis isolate, 89-T-34-22, belonging to the serovar shandongiensis (H22) produced noninsecticidal and nonhemolytic proteins crystallizing into irregular-shaped parasporal inclusions. The proteins showed in vitro cytotoxicity to human cells, including cancer cells, only when activated by protease tre...

journal_title：Biochemical and biophysical research communications

authors： Lee DW,Akao T,Yamashita S,Katayama H,Maeda M,Saitoh H,Mizuki E,Ohba M

更新日期：2000-05-27 00:00:00

abstract：:Monomethylethanolamine (1 mM) and dimethylethanolamine (1 mM) stimulated DNA synthesis 10- and 15-fold, respectively, in NIH 3T3 fibroblasts. In addition, simultaneous treatments with insulin (500 nM) and methylated ethanolamine analogues (1 mM or less) resulted in synergistic activation of DNA synthesis. The order of...

journal_title：Biochemical and biophysical research communications

authors： Kiss Z,Crilly KS,Anderson WB

更新日期：1996-03-07 00:00:00

abstract：:The importance of circular RNAs (circRNAs) in human cancers has gradually been acknowledged. In hepatocellular carcinoma (HCC), several circRNAs have been reported to regulate tumor growth and metastasis. However, the role of hsa_circ_0000673 in HCC remains largely unknown. In this study, we found that hsa_circ_000067...

journal_title：Biochemical and biophysical research communications

authors： Jiang W,Wen D,Gong L,Wang Y,Liu Z,Yin F

更新日期：2018-06-02 00:00:00

abstract：:We have identified and characterized insulin receptors on Chinese hamster ovary (CHO) cells. Insulin binds in a time, temperature and pH dependent fashion and insulin analogues compete for 125I-insulin binding in order of their biological potencies. Furthermore, two CHO cell glycosylation mutants, B4-2-1, lacking high...

journal_title：Biochemical and biophysical research communications

authors： Podskalny J,McElduff A,Gorden P

更新日期：1984-11-30 00:00:00

abstract：:We find that the low frequency Raman spectrum of Zn(II) metallothionein has a single prominent band at 138 cm-1 which is absent from the Raman spectrum of the metal-free protein. This feature is also found for Cd(II) binding to both of the independent metallothionein domains and the metallothionein from Neurospora cra...

journal_title：Biochemical and biophysical research communications

authors： Elgren TE,Wilcox DE

更新日期：1989-09-15 00:00:00

abstract：:Preadipocytes constitutively express GATA-2 and GATA-3 that are required to halt the cells at the undifferentiated stage. However, we unexpectedly found that K-7174, a GATA-specific inhibitor, did not induce but rather inhibited differentiation of 3T3-L1 preadipocytes. It was associated with lack of lipid accumulation...

journal_title：Biochemical and biophysical research communications

authors： Shimada T,Hiramatsu N,Okamura M,Hayakawa K,Kasai A,Yao J,Kitamura M

更新日期：2007-11-16 00:00:00

abstract：:We have used human neuroblastoma NB-OK1 cells to investigate the regulation of neurite outgrowth. Carbachol suppressed forskolin-stimulated neurite outgrowth in NB-OK1 cells although forskolin-stimulated cAMP levels were enhanced. The dose-response curve for this suppression was very similar to that for stimulation of...

journal_title：Biochemical and biophysical research communications

authors： Nakagawa-Yagi Y,Saito Y,Takada Y,Nakamura H

更新日期：1992-01-15 00:00:00

abstract：:Tankyrases (TNKS and TNKS2) are enzymes that catalyze poly-ADP-ribosylation (PARsylation) of their target proteins. Tankyrase-mediated PARsylation plays critical regulatory roles in cell signaling, particularly in the Wnt/β-catenin pathway. The sterile alpha motif (SAM) domain in tankyrases mediates their oligomerizat...

journal_title：Biochemical and biophysical research communications

authors： Fan C,Yarravarapu N,Chen H,Kulak O,Dasari P,Herbert J,Yamaguchi K,Lum L,Zhang X

更新日期：2018-09-10 00:00:00

abstract：:The 5mC DNA methyltransferase M.HhaI can be split into two individually inactive N- and C-terminal fragments that together can form an active enzyme in vivo capable of efficiently methylating DNA. This active fragment pair was identified by creating libraries of M.HhaI gene fragment pairs and then selecting for the pa...

journal_title：Biochemical and biophysical research communications

authors： Choe W,Chandrasegaran S,Ostermeier M

更新日期：2005-09-09 00:00:00

abstract：:Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vas...

journal_title：Biochemical and biophysical research communications

authors： Hata F,Ishii T,Kanada A,Yamano N,Kataoka T,Takeuchi T,Yagasaki O

更新日期：1990-11-15 00:00:00

abstract：:Tooth and bone are major tissues involved in physiological calcification in the body, and they use similar molecular pathways for development, homeostasis, and regeneration. Harmine (HMN) is a natural small compound that stimulates osteoblast differentiation in vitro and in vivo. Here we examined the biological effect...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara N,Lee JW,Kumakami-Sakano M,Otsu K,Woo JT,Iseki S,Ota MS

更新日期：2018-03-11 00:00:00

abstract：:A PCR-based Sma I restriction fragment length polymorphism (RFLP) in the human D4 dopamine receptor (DRD4) gene was investigated in 200 subjects each of Japanese and Mongolian populations. When compared to allele frequencies for Caucasians previously reported by Petronis et al., Japanese and Mongolian populations show...

journal_title：Biochemical and biophysical research communications

authors： Nakatome M,Honda K,Tun Z,Wakasugi C

更新日期：1996-03-27 00:00:00

abstract：BACKGROUND:In-stent restenosis (ISR) is a complex disease that occurs after coronary stenting procedures. The development of quality materials and improvement of our understanding on significant factors regulating ISR are essential for enhancing prognosis. Vascular smooth muscle cells (VSMCs) are the main constituent c...

journal_title：Biochemical and biophysical research communications

authors： Han L,Yin Q,Yang L,van Rijn P,Yang Y,Liu Y,Li M,Yan M,Zhou Q,Yu T,Lian Z

更新日期：2020-06-04 00:00:00

abstract：:Farnesoid X receptor (FXR), a bile acid receptor, is known to be involved in the promotion of adipogenesis. However, the regulation mechanism of FXR-promoted adipogenesis remains unclear. In this study, we investigated the regulation mechanism of FXR-mediated activation of adipogenesis in murine adipocyte 3T3-L1 cells...

journal_title：Biochemical and biophysical research communications

authors： Shinohara S,Fujimori K

更新日期：2020-06-18 00:00:00

abstract：:K+ channels are integral membrane proteins, which contribute to maintain vital parameters such as the cellular membrane potential and cell volume. Malaria parasites encode two K+ channel homologues, Kch1 and Kch2, which are well-conserved among members of the Plasmodium genus. In the rodent malaria parasite P. berghei...

journal_title：Biochemical and biophysical research communications

authors： Ellekvist P,Mlambo G,Kumar N,Klaerke DA

更新日期：2017-11-04 00:00:00

abstract：:Screening for inhibitors of DNA-dependent protein kinase (DNA-PK) revealed 3-cyano-5-(4-pyridyl)-6-hydrazonomethyl-2-pyridone, designated OK-1035, to be a potent and selective inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM, a concentration more...

journal_title：Biochemical and biophysical research communications

authors： Take Y,Kumano M,Hamano Y,Fukatsu H,Teraoka H,Nishimura S,Okuyama A

更新日期：1995-10-04 00:00:00

abstract：:Chemerin is a chemoattractant cytokine (chemokine) produced by adipocytes and hepatocytes; it regulates insulin sensitivity and adipocyte differentiation. The objective of this study was to investigate the effect of chemerin on the expression of genes related to lactogenesis and the regulators of chemerin signaling in...

journal_title：Biochemical and biophysical research communications

authors： Suzuki Y,Haga S,Katoh D,So KH,Choi KC,Jung US,Lee HG,Katoh K,Roh SG

更新日期：2015-10-23 00:00:00

abstract：:Augmenter of liver regeneration (ALR) is known to support liver regeneration and to stimulate proliferation of hepatocytes. However, it is not known if ALR exerts anti-apoptotic effects in human hepatocytes and whether this protective effect is cell type specific. This is relevant, because compounds that protect the l...

journal_title：Biochemical and biophysical research communications

authors： Ilowski M,Kleespies A,de Toni EN,Donabauer B,Jauch KW,Hengstler JG,Thasler WE

更新日期：2011-01-07 00:00:00

abstract：:Recent advances in cancer biology reveal the importance of metabolic changes in cancer; however, less is known about how metabolic pathways in tumors are regulated in vivo. Here, we report analysis of the lung cancer metabolism based on different surgical procedures, namely lobectomy and partial resection. In lobectom...

journal_title：Biochemical and biophysical research communications

authors： Kikuchi N,Soga T,Nomura M,Sato T,Sakamoto Y,Tanaka R,Abe J,Morita M,Shima H,Okada Y,Tanuma N

更新日期：2020-09-10 00:00:00

abstract：:The 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and its 2',3'-didehydro derivative (ddeDAPR) are poor substrates for adenosine deaminase (ADA) but potent inhibitors of the enzyme. Their Km values for ADA are of the same order of magnitude as those of the natural adenosine (Ado) and 2'-deoxyadenosine (dAdo), bu...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,Robins MJ,Zou RM,Herdewijn P,De Clercq E

更新日期：1987-05-29 00:00:00