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Insulin receptors on Chinese hamster ovary (CHO) cells: altered insulin binding to glycosylation mutants.

Abstract：

:We have identified and characterized insulin receptors on Chinese hamster ovary (CHO) cells. Insulin binds in a time, temperature and pH dependent fashion and insulin analogues compete for 125I-insulin binding in order of their biological potencies. Furthermore, two CHO cell glycosylation mutants, B4-2-1, lacking high mannose containing glycoproteins, and Lec 1.3c, lacking complex carbohydrate containing glycoproteins, bind insulin with a much higher and lower affinity respectively than wild type cells. This is the first report of insulin receptors on CHO cells and the first to use glycosylation mutants to study the effects of abnormal carbohydrates on insulin binding.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Podskalny J,McElduff A,Gorden P

doi

10.1016/s0006-291x(84)80335-6

subject

Has Abstract

pub_date

1984-11-30 00:00:00

pages

70-5

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)80335-6

journal_volume

125

pub_type

杂志文章

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