Specificity of thyroglobulin interactions with thyroid cells and membranes.

abstract：:The expression of the transcription factor Sp1 and EGF receptor (EGFR) was examined on human gastric carcinoma cell lines and gastric carcinoma tissues as well as corresponding normal mucosa in order to clarify the mechanism of overexpression of EGFR gene without gene amplification. All 7 carcinoma cell lines expresse...

journal_title：Biochemical and biophysical research communications

authors： Kitadai Y,Yasui W,Yokozaki H,Kuniyasu H,Haruma K,Kajiyama G,Tahara E

更新日期：1992-12-30 00:00:00

abstract：:Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived ...

journal_title：Biochemical and biophysical research communications

authors： Zhang S,Jiang L,Che F,Lu Y,Xie Z,Wang H

更新日期：2017-11-04 00:00:00

abstract：:Recent studies indicate that galactoside-binding proteins may bind the poly-N-acetyllactosamine sequences of laminin. We questioned whether human galactoside-binding protein (hL-31) binds to laminin and whether cells that express hL-31 on their surface use it as a laminin receptor to promote cellular attachment. The d...

journal_title：Biochemical and biophysical research communications

authors： Ochieng J,Gerold M,Raz A

更新日期：1992-08-14 00:00:00

abstract：:We have previously shown that murine solid tumor cells express high affinity IL-4 receptors (IL-4R) which are internalized after binding to ligand. In the present study, we have examined the regulation of IL-4R by TNF. We demonstrate that TNF upregulated the expression of IL-4R on murine MCA-106 sarcoma cells. Maximum...

journal_title：Biochemical and biophysical research communications

authors： Puri RK,Leland P

更新日期：1993-12-30 00:00:00

abstract：:Toll-like receptor 4 (TLR4) activates two distinct signaling pathways inducing production of proinflammatory cytokines or type I interferons (IFNs), respectively. MyD88 and TIRAP/Mal are essential adaptor molecules for the former but not for the latter pathway. In contrast, TRIF/TICAM-1 and TRAM/TICAM-2 are essential ...

journal_title：Biochemical and biophysical research communications

authors： Tanimura N,Saitoh S,Matsumoto F,Akashi-Takamura S,Miyake K

更新日期：2008-03-28 00:00:00

abstract：:Transglutaminase 2 (TGase 2) is a bifunctional enzyme that catalyzes calcium-dependent transamidation and GTP binding/hydrolysis. The transamidation activity is proposed to be associated with several neurodegenerative disorders such as Alzheimer's and Hungtinton's disease. However, the regulation mechanism by which TG...

journal_title：Biochemical and biophysical research communications

authors： Jeon JH,Cho SY,Kim CW,Shin DM,Kweon JC,Choi KH,Park SC,Kim IG

更新日期：2002-06-21 00:00:00

abstract：:The effect of reactive oxygen on cytosolic free calcium concentration [( Ca++]i) in pig aortic endothelial cells (ECs) was studied. Linoleate hydroperoxide (LHO) and superoxide radicals generated from xanthine with xanthine oxidase (X-XO) were used as sources of reactive oxygen. [Ca++]i in ECs was measured with quin 2...

journal_title：Biochemical and biophysical research communications

authors： Hirosumi J,Ouchi Y,Watanabe M,Kusunoki J,Nakamura T,Orimo H

更新日期：1988-04-15 00:00:00

abstract：:The expansion of a CAG trinucleotide repeat (TNR) sequence has been linked to several neurological disorders, for example, Huntington's disease (HD). In HD, healthy individuals have 5-35 CAG repeats. Those with 36-39 repeats have the premutation allele, which is known to be prone to expansion. In the disease state, gr...

journal_title：Biochemical and biophysical research communications

authors： Jarem DA,Delaney S

更新日期：2011-12-09 00:00:00

abstract：:In mammals dietary ferric iron is reduced to ferrous iron for more efficient absorption by the intestine. Analysis of a pig duodenal membrane fraction revealed two NADH-dependent ferric reductase activities, one associated with a b-type cytochrome and the other not. Purification and characterization of the non-cytochr...

journal_title：Biochemical and biophysical research communications

authors： Lee PL,Halloran C,Cross AR,Beutler E

更新日期：2000-05-19 00:00:00

abstract：:Monoclonal antibody BB1 was previously shown to recognize the CD80 protein as well as a putative B7.3 molecule, both ligands of the important T-cell receptors CD28 and CTLA-4. We report that BB1 coprecipitated from detergent lysates of human B- and pre-B-cell lines a protein kinase activity, as detected by solid phase...

journal_title：Biochemical and biophysical research communications

authors： Angelisová P,Cerný J,Horejsí V

更新日期：1996-11-12 00:00:00

abstract：:Mutations of the mitochondria DNA (mtDNA) displacement loop (D-loop) were investigated to clarify different changes of exogenous and endogenous liver carcinogenesis in rats. We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet. DN...

journal_title：Biochemical and biophysical research communications

authors： Onishi M,Sokuza Y,Nishikawa T,Mori C,Uwataki K,Honoki K,Tsujiuchi T

更新日期：2007-10-12 00:00:00

abstract：:We report here on characterization of a novel human gene on chromosome 2q32, containing several ankyrin repeats and ARM domains. The gene FLJ25415, including at least 31 exons and spanning about 90kb of a gene-rich genomic region, is present in the human genome as a single copy. It seems highly conserved along the mam...

journal_title：Biochemical and biophysical research communications

authors： Occhi G,Olivieri M,Rampazzo A,Danieli GA

更新日期：2004-05-21 00:00:00

abstract：:Myocardial stunning (temporary post-ischaemic contractile dysfunction) may be caused by oxidative stress and/or impaired myocyte calcium homeostasis. Regional myocardial stunning was induced in open-chest pigs (segment shortening reduced to 68.3+/-4.7% of baseline) by repetitive brief circumflex coronary occlusion (I/...

journal_title：Biochemical and biophysical research communications

authors： Kumar S,Hall RJ,Mani AR,Moore KP,Camici PG,Rimoldi OE,Williams AJ,Macleod KT

更新日期：2009-09-11 00:00:00

abstract：:Liver regeneration is controlled by multiple signaling pathways induced by a variety of growth factors, hormones, and cytokines. Here we report that protein kinase B (PKB)/Akt, part of a key cell survival signaling pathway, is markedly activated after partial hepatectomy (PHX). The antiapoptotic protein Bad, a downstr...

journal_title：Biochemical and biophysical research communications

authors： Hong F,Nguyen VA,Shen X,Kunos G,Gao B

更新日期：2000-12-29 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) is a critical immunosuppressive cytokine that inhibits the cell-mediated immune responses partly via inhibition of immunostimulatory cytokine production from T cells, NK cells, and macrophages. Here we investigated the effect of TGFbeta on NK cell activation induced by interle...

journal_title：Biochemical and biophysical research communications

authors： Hayashi H,Inoue Y,Tsutsui H,Okamura H,Nakanishi K,Onozaki K

更新日期：2003-01-24 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) has been implicated in the development of diabetic glomerulopathy. In order to evaluate a role of Smad3, one of the major signaling molecules downstream of TGF-beta, in the pathogenesis of diabetic glomerulopathy, Smad3-null mice were made diabetic with streptozotocin injecti...

journal_title：Biochemical and biophysical research communications

authors： Fujimoto M,Maezawa Y,Yokote K,Joh K,Kobayashi K,Kawamura H,Nishimura M,Roberts AB,Saito Y,Mori S

更新日期：2003-06-13 00:00:00

abstract：:We describe a new method for multi-wavelength immunoassays using surface plasmon-coupled emission (SPCE). This phenomenon is coupling of excited fluorophores with a nearby thin metal film, in our case silver, resulting in strongly directional emission into the underlying glass substrate. The angle at which the radiati...

journal_title：Biochemical and biophysical research communications

authors： Matveeva E,Malicka J,Gryczynski I,Gryczynski Z,Lakowicz JR

更新日期：2004-01-16 00:00:00

abstract：:A170 is an oxidative stress-inducible protein having a Zinc finger domain, two PEST sequences, and many potential phosphorylation sites for serine/threonine kinases. These structural features suggest that the phosphorylation of A170 affects its function and degradation. We have found that A170 is phosphorylated in cul...

journal_title：Biochemical and biophysical research communications

authors： Yanagawa T,Yuki K,Yoshida H,Bannai S,Ishii T

更新日期：1997-12-08 00:00:00

abstract：:An infection of any part of female reproductive tract can severely interfere with fertility and reproduction. The fluids and epithelium from the lumen of the female reproductive tract (uterus, oviduct and ovarian follicle) are a known source of antimicrobial action in several species. In this study, we compared the an...

journal_title：Biochemical and biophysical research communications

authors： Dráb T,Kračmerová J,Hanzlíková E,Černá T,Litváková R,Pohlová A,Tichá M,Přikryl P,Liberda J

更新日期：2014-01-17 00:00:00

abstract：:This study aimed to investigate possible feedback mechanisms in the control of collagenase (matrix metalloproteinase-1) and tissue inhibitor of metalloproteinases (TIMP-1). Procollagenase, active collagenase, TIMP-1 and collagenase-TIMP complex were applied to human skin and synovial fibroblasts for 48 hours, the cell...

journal_title：Biochemical and biophysical research communications

authors： Clark IM,Powell LK,Cawston TE

更新日期：1994-09-15 00:00:00

abstract：:The small GTPase Rheb binds and activates mTORC1, which plays a pivotal role in diverse cellular physiologies. To increase our understanding of how Rheb regulates mTORC1 signaling, we set out to identify Rheb binding proteins using shotgun proteomics approaches. In this study, we characterized HSP70, one of the identi...

journal_title：Biochemical and biophysical research communications

authors： Ryu HH,Ha SH

更新日期：2020-12-17 00:00:00

abstract：:Putative E2/NS1 sequence of hepatitis C virus was expressed in E. coli as a fusion protein with maltose binding protein. Approximately 80 kDa protein was obtained containing 38 kDa E2/NS1 protein. The antibody to this protein was detectable in the same serum from which the sequence was amplified. It was also detectabl...

journal_title：Biochemical and biophysical research communications

authors： Yokosuka O,Ito Y,Imazeki F,Ohto M,Omata M

更新日期：1992-11-30 00:00:00

abstract：:We quantified the damage yields produced in plasmid DNA by γ-irradiation in the presence of low concentrations (10-100 μM) of ascorbic acid, which is a major antioxidant in living systems, to clarify whether it chemically repairs radiation damage in DNA. The yield of DNA single strand breaks induced by irradiation was...

journal_title：Biochemical and biophysical research communications

authors： Hata K,Urushibara A,Yamashita S,Shikazono N,Yokoya A,Katsumura Y

更新日期：2013-05-03 00:00:00

abstract：:We previously showed that the epidermal growth factor (EGF) receptor in human A431 epidermoid carcinoma cells undergoes a slow post-translational modification whereby it acquires (t1/2 = 30-40 min) EGF binding capacity (Slieker, L.J., et. al. (1986) J. Biol. Chem., 261, 15233-15241). This activation occurs in the endo...

journal_title：Biochemical and biophysical research communications

authors： Slieker LJ,Martensen TM,Lane MD

更新日期：1988-05-31 00:00:00

abstract：:The only outer mitochondrial membrane cytochrome b(5) examined to date, from rat (rOM b(5)), exhibits greater stability than known mammalian microsomal (Mc) isoforms, as well as a much higher kinetic barrier for hemin dissociation and a more negative reduction potential. A BlastP search of available databases using th...

journal_title：Biochemical and biophysical research communications

authors： Altuve A,Wang L,Benson DR,Rivera M

更新日期：2004-02-06 00:00:00

abstract：:The objective of this study was to investigate the exact therapeutic effects of Verapamil on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the molecular mechanism involved, through using LPS-induced animal models as well as LPS-stimulated mouse primary peritoneal macrophages models. Our results demonstr...

journal_title：Biochemical and biophysical research communications

authors： Song Z,Li S,Zhang C,Yuan L,Han L,Liu Y

更新日期：2019-10-01 00:00:00

abstract：:Apoptin, a small protein encoded by chicken anemia virus (CAV), induces cell death specifically in cancer cells. In normal cells, Apoptin remains in the cytoplasm; whereas in cancerous cells, it migrates into the nucleus and kills the cell. Cellular localization appears to be crucial. Through a yeast two-hybrid screen...

journal_title：Biochemical and biophysical research communications

authors： Huo DH,Yi LN,Yang J

更新日期：2008-07-18 00:00:00

abstract：:Insulin resistance is a cardinal feature of Type 2 Diabetes (T2D), which accompanied by lipid accumulation and TNF-α overexpression in skeletal muscle. The role of TNF-α in palmitate-induced insulin resistance remained to be elucidated. Here, we assessed effects of TNF-α knockdown on the components of insulin signalin...

journal_title：Biochemical and biophysical research communications

authors： Haghani K,Pashaei S,Vakili S,Taheripak G,Bakhtiyari S

更新日期：2015-05-15 00:00:00

abstract：:We have demonstrated binding sites for LTB4 in guinea pig lung membranes. Binding of [3H]-LTB4 was of high affinity (Kd = 0.76 nM), saturable and linear with protein concentration (0.2-1.2 mg/ml). Scatchard and Hill's plot analysis indicated a single class of binding site with a Hill's coefficient of 0.99 +/- 0.08 (n ...

journal_title：Biochemical and biophysical research communications

authors： Saad M,Wong K

更新日期：1987-02-27 00:00:00

abstract：:Based on a homology search with endostatin, the C-terminus 185 aa of collagen XVIII, we report the cloning, expression, and antiangiogenic activity of a 22 kDa human collagen XV fragment, that we have named restin. Restin was expressed in the prokaryotic pET expression system. We have shown that restin inhibits the mi...

journal_title：Biochemical and biophysical research communications

authors： Ramchandran R,Dhanabal M,Volk R,Waterman MJ,Segal M,Lu H,Knebelmann B,Sukhatme VP

更新日期：1999-02-24 00:00:00