Nucleotide sequence of the promoter region of the melibiose operon of Escherichia coli.

abstract：:Xanthurenic acid is an endogenous molecule leading to caspase-9 and -3 activation. Here we report that xanthurenic acid targets signalling proteins 14-3-3 into lysosomes leading to interruption protein/protein interaction. Xanthurenic acid changed the localisation of 14-3-3 in the cells. At a concentration of 10 and 2...

journal_title：Biochemical and biophysical research communications

authors： Malina HZ,Frueh BE

更新日期：2003-10-17 00:00:00

abstract：:Mammalian cells contain two fatty acid synthesis pathways, the cytosolic FASI pathway, and the mitochondrial FASII pathway. The selection behind the conservation of the mitochondrial pathway is not completely understood, given the presence of the cytosolic FAS pathway. In this study, we show through heterologous gene ...

journal_title：Biochemical and biophysical research communications

authors： Parl A,Mitchell SL,Clay HB,Reiss S,Li Z,Murdock DG

更新日期：2013-11-15 00:00:00

abstract：:In vitro produced mammalian embryos suffer from developmental failure, with a large proportion showing embryonic retardation, degradation, or apoptosis. This failure is due, in part, to incomplete oocyte cytoplasmic maturation. C-type natriuretic peptide (CNP) has been reported to act as a meiotic inhibitor. Here we e...

journal_title：Biochemical and biophysical research communications

authors： Zhang T,Fan X,Li R,Zhang C,Zhang J

更新日期：2018-02-26 00:00:00

abstract：:The flavanol (-)-epicatechin has been found to protect against damage inflicted by peroxynitrite, an inflammatory intermediate. Here, epicatechin was tested in systems of increasing complexity. The compound efficiently protected against nitration of protein tyrosine residues by peroxynitrite (IC(50) approximately 0.02...

journal_title：Biochemical and biophysical research communications

authors： Schroeder P,Klotz LO,Buchczyk DP,Sadik CD,Schewe T,Sies H

更新日期：2001-07-20 00:00:00

abstract：:MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS) miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to the difficulties in miRNA delivery, warranting the development of a novel drug delivery system (DDS). Exosomes are stable in circulat...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi M,Sawada K,Miyamoto M,Shimizu A,Yamamoto M,Kinose Y,Nakamura K,Kawano M,Kodama M,Hashimoto K,Kimura T

更新日期：2020-06-18 00:00:00

abstract：:The mitochondrial uncoupling protein UCP-1 uncouples respiration from ATP synthesis in brown adipose tissue (BAT) and thus energy is dissipated as heat. Recently two further isoforms have been identified which may play a similar role in other tissues. We have determined the effects of the rodent-selective beta3-adreno...

journal_title：Biochemical and biophysical research communications

authors： Emilsson V,Summers RJ,Hamilton S,Liu YL,Cawthorne MA

更新日期：1998-11-18 00:00:00

abstract：:We report that the human 1,25-dihydroxyvitamin D3 receptor is an efficient substrate for cAMP-dependent protein kinase, in vitro. This phosphorylation reaction is rapid and neither dependent upon nor significantly affected by the presence of the 1,25-dihydroxyvitamin D3 ligand. Preliminary mapping experiments utilizin...

journal_title：Biochemical and biophysical research communications

authors： Jurutka PW,Hsieh JC,Haussler MR

更新日期：1993-03-31 00:00:00

abstract：:Death-associated protein kinase (DAPk) family has emerged as a novel subfamily of pro-apoptotic serine/threonine kinase in the last 10 years. Although the functions of DAPk have been well documented, those of other family members remain uncertain. In this work, we characterized the expression pattern of human DAPk lik...

journal_title：Biochemical and biophysical research communications

authors： Wu Y,Yan Q,Zuo J,Saiyin H,Jiang W,Qiao S,Yu L

更新日期：2010-02-19 00:00:00

abstract：:We have investigated why the recycling of eIF-2.GDP to eIF-2.GTP, mediated by the guanine nucleotide exchange factor eIF-2B, is rapid in rabbit reticulocyte lysate, reconstituted for optimal protein synthesis, but slow in an isolated reaction with purified eIF-2B. We have found that purified eIF-2B dissociates eIF-2.[...

journal_title：Biochemical and biophysical research communications

authors： Gross M,Rubino MS,Hessefort SM

更新日期：1991-12-31 00:00:00

abstract：:Receptor-mediated responses to prostaglandins E1 and E2 are shown by electrophysiological methods in follicle-enclosed oocytes of Xenopus laevis. In voltage-clamped oocytes, prostaglandins E1 and E2 elicited an outward hyperpolarizing current. This outward membrane current was caused by an increase in K+ conductance. ...

journal_title：Biochemical and biophysical research communications

authors： Mori K,Oka S,Tani A,Ito S,Watanabe Y

更新日期：1989-08-15 00:00:00

abstract：:A soluble protein that binds malonyl-CoA without requiring cofactors has been purified from rat liver. Until saturated, it competes with fatty acid synthetase for free malonyl-CoA, temporarily reducing the rate of fatty acid synthesis at low levels of malonyl-CoA, as in fatty acid synthetase--coupled assays for acetyl...

journal_title：Biochemical and biophysical research communications

authors： Dugan RE,Osterlund BR,Drong RF,Swenson TL

更新日期：1987-08-31 00:00:00

abstract：:The Transforming Growth Factor-beta (TGF beta) family of polypeptides elicits diverse biological actions on a wide range of cell types. There are known to be several isoforms of TGF beta coded for by different genes, with possibly differential expression and potencies. We have demonstrated that there is constitutive e...

journal_title：Biochemical and biophysical research communications

authors： Frazer A,Seid JM,Hart KA,Bentley H,Bunning RA,Russell RG

更新日期：1991-10-31 00:00:00

abstract：:The anthrax lethal factor (LF) is a Zn(2+)-endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N-terminal region. Much line of effort was carried out to elucidate the catalytic activity of LF for designing the inhibitor and to understand the cellular mechanism o...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Chai YG,Yoon MY

更新日期：2004-01-02 00:00:00

abstract：:We compared the nitric oxide (NO)-generating behavior of nitroglycerin (NTG), pentaerythritol trinitrate (PEtriN) and isosorbide dinitrate (ISDN), in the microsomal preparation of bovine coronary artery smooth muscle cells. The comparative NO generating activities among these nitrates were consistent with their relati...

journal_title：Biochemical and biophysical research communications

authors： Chung SJ,Fung HL

更新日期：1992-06-30 00:00:00

abstract：:CPI-17 is a protein phosphatase 1 (PP1) inhibitor that has been shown to act on the myosin light chain phosphatase. CPI-17 is phosphorylated on Thr-38 in vivo, thus enhancing its ability to inhibit PP1. Thr-38 has been shown to be the target of several protein kinases in vitro. Originally, the expression of CPI-17 was...

journal_title：Biochemical and biophysical research communications

authors： Dubois T,Howell S,Zemlickova E,Learmonth M,Cronshaw A,Aitken A

更新日期：2003-03-07 00:00:00

abstract：:The pattern of micrococcal nuclease digestion of chromatin from different organs of Allium cepa has been studied. The DNA from small oligonucleosomes appears to be highly degraded and heterogeneous. In solutions of intermediate ionic strength (0.15 M NaCl) histones H2A and H2B form dimers, however at high salt concent...

journal_title：Biochemical and biophysical research communications

authors： Moreno ML,Puigdomenech P,Palau J

更新日期：1985-06-28 00:00:00

abstract：:Our previous studies showed that basic fibroblast growth factor 2 (FGF2) null mice display markedly reduced bone mass and bone formation. However, the mechanism by which FGF2 regulates bone mass or bone formation is not fully defined. Activating transcription factor 4 (ATF4), one member of activating transcription fac...

journal_title：Biochemical and biophysical research communications

authors： Fei Y,Xiao L,Hurley MM

更新日期：2010-01-01 00:00:00

abstract：:Of two major isoforms of angiotensin II receptors, AT1 and AT2, biological roles of AT2 remain unclear. Using vascular smooth muscle cells, we investigated the regulation of expression of AT2 by growth factors in comparison with that of AT1. The cultured rat aorta smooth muscle cells had detectable AT2 binding sites, ...

journal_title：Biochemical and biophysical research communications

authors： Kambayashi Y,Bardhan S,Inagami T

更新日期：1993-07-15 00:00:00

abstract：:Most G protein-coupled receptors (GPCRs) are N-glycosylated proteins but the role of this post-translational modification in GPCR biosynthesis has not been extensively studied. We previously showed that the non-glycosylated AT(1) receptor is inefficiently expressed at the cell surface. In this study, we addressed whet...

journal_title：Biochemical and biophysical research communications

authors： Lanctôt PM,Leclerc PC,Escher E,Guillemette G,Leduc R

更新日期：2006-02-10 00:00:00

abstract：:The Tat protein from HIV-1 fused with heterologous proteins traverses biological membranes in a transcellular process called: protein transduction. This has already been successfully exploited in various biological models, but never in the nematode worm Caenorhabditis elegans. TAT-eGFP or GST-eGFP proteins were fed to...

journal_title：Biochemical and biophysical research communications

authors： Delom F,Fessart D,Caruso ME,Chevet E

更新日期：2007-01-19 00:00:00

abstract：:The senescence-accelerated mouse prone 8 (SAMP8) strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. Combined linkage analysis of 264 F2 intercross SAMP8 × JF1 mice and RNA-seq analysis identified Hcn1 gene out of 29 genes in the LMD region on chromosome 13. Hcn1 in SAMP8 strain showed 1...

journal_title：Biochemical and biophysical research communications

authors： Akbor MM,Tomobe K,Yamada T,Kim J,Mano H,Kurosawa N,Sasaki K,Nomura Y,Isobe M

更新日期：2013-11-08 00:00:00

abstract：:Experiments were undertaken to examine the effects of reduced (GSH) and oxidized (GSSG) glutathione on lipid peroxidation of rat liver microsomes. Dependence on microsomal alpha-tocopherol was shown for the GSH inhibition of lipid peroxidation. However, when GSH (5 mM) and GSSG (2.5 mM) were combined in the assay syst...

journal_title：Biochemical and biophysical research communications

authors： Scholz RW,Graham KS,Reddy CC

更新日期：1990-01-30 00:00:00

abstract：:We investigated immunohistochemically the localization of p33, an endogenous substrate protein for an arginine-specific ADP-ribosyltransferase in chicken liver. Polymorphonuclear-pseudo-eosinophilic granulocytes (heterophils) in interlobular connective tissues of the liver were exclusively and strongly stained with th...

journal_title：Biochemical and biophysical research communications

authors： Osago H,Mishima K,Tsuchiya M,Tanigawa Y,Umeno T,Shimoyama M

更新日期：1991-10-15 00:00:00

abstract：:Follistatin, activin and inhibin proteins are produced by granulosa cells, but the mechanisms controlling their production remain unclear. Here, we examined how the protein kinase A (PKA) and protein kinase C (PKC) pathways act and interact to regulate production of these proteins. Granulosa cells from immature rats w...

journal_title：Biochemical and biophysical research communications

authors： Miyanaga K,Erickson GF,DePaolo LV,Ling N,Shimasaki S

更新日期：1993-07-15 00:00:00

abstract：:Chemerin is a chemoattractant cytokine (chemokine) produced by adipocytes and hepatocytes; it regulates insulin sensitivity and adipocyte differentiation. The objective of this study was to investigate the effect of chemerin on the expression of genes related to lactogenesis and the regulators of chemerin signaling in...

journal_title：Biochemical and biophysical research communications

authors： Suzuki Y,Haga S,Katoh D,So KH,Choi KC,Jung US,Lee HG,Katoh K,Roh SG

更新日期：2015-10-23 00:00:00

abstract：:The cytochrome P-450 catalyzing 26-hydroxylation of C27-steroids (cytochrome P-450(26] was purified from rabbit liver mitochondria. The specific content of the cytochrome P-450 was 13.6 nmol per mg of protein and the 26-hydroxylase activity towards 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol was 31,300 pmol/nmo...

journal_title：Biochemical and biophysical research communications

authors： Dahlbäck H

更新日期：1988-11-30 00:00:00

abstract：:Protein fractions that overcome m7GMP inhibition of mRNA translation have been purified from the yeast S. cerevisiae. An active fraction isolated from polysomes contains two polypeptides of 220- and 190-kDa. The active fraction isolated from postribosomal supernatant contains a major polypeptide of 28-kDa and other sp...

journal_title：Biochemical and biophysical research communications

authors： Parets Suler A,Zueco J,Gozalbo D,Sentandreu R

更新日期：1987-08-14 00:00:00

abstract：:Angiogenesis is critical to a wide range of physiological and pathological processes. Scutellarin, a major flavonoid of a Chinese herbal medicine Erigeron breviscapus (Vant.) Hand. Mazz. has been shown to offer beneficial effects on cardiovascular and cerebrovascular functions. However, scutellarin's effects on angiog...

journal_title：Biochemical and biophysical research communications

authors： Gao ZX,Huang DY,Li HX,Zhang LN,Lv YH,Cui HD,Zheng JH

更新日期：2010-09-10 00:00:00

abstract：:The telomere-associated protein tankyrase 1 is a poly(ADP-ribose) polymerase and is considered to be a promising target for cancer therapy, especially for BRCA-associated cancers. However, an efficient assay system for inhibitor screening has not been established, mainly due to the difficulty of efficient preparation ...

journal_title：Biochemical and biophysical research communications

authors： Yashiroda Y,Okamoto R,Hatsugai K,Takemoto Y,Goshima N,Saito T,Hamamoto M,Sugimoto Y,Osada H,Seimiya H,Yoshida M

更新日期：2010-04-09 00:00:00

abstract：:We have isolated a new recombinant antigen 'PV12' of Plasmodium vivax by immunological screening of the genomic library. The antigen shows a sequence homology with human apolipoprotein B-100. A large number of P. vivax infected individuals (79%) were seropositive against this antigen. The probable function of this ant...

journal_title：Biochemical and biophysical research communications

authors： Ray P,Sharma YD

更新日期：1992-04-30 00:00:00