Decrease in cytosolic free Ca2+ and enhanced proteoglycan synthesis induced by cartilage derived growth factors in cultured chondrocytes.

abstract：:Probiotics exhibit beneficial functions for host homeostasis maintenance. We herein investigated the mechanism by which Lactobacillus brevis-derived poly P exhibited a beneficial function. Immunostaining indicated that poly P was captured in the plasma membrane via integrin β1 in Caco2/bbe cells. The uptake of poly P ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka K,Fujiya M,Konishi H,Ueno N,Kashima S,Sasajima J,Moriichi K,Ikuta K,Tanabe H,Kohgo Y

更新日期：2015-11-20 00:00:00

abstract：:Osteoclasts which derive from hemopoietic cells are multinucleated cells responsible for bone resorption. We found that cyclopiazonic acid (CPA), thapsigargin (TG), and 2,5-di-(t-butyl)-1,4-hydroquinone (BHQ) induced osteoclast-like cell (OCL) formation in cocultures of mouse calvaria-derived stromal cells and hemopoi...

journal_title：Biochemical and biophysical research communications

authors： Takami M,Woo JT,Takahashi N,Suda T,Nagai K

更新日期：1997-08-08 00:00:00

abstract：:Diffuse panbronchiolitis (DPB) is a chronic progressive disease of the respiratory bronchioles, and has been improved by low-dose, long-term erythromycin (EMC) treatment. The therapeutic benefits may be derived from its anti-inflammatory and immunomodulatory properties rather than antimicrobial effect. However, there ...

journal_title：Biochemical and biophysical research communications

authors： Park SJ,Lee YC,Rhee YK,Lee HB

更新日期：2004-11-05 00:00:00

abstract：:We examined the expression of a Caenorhabditis elegans (C. elegans) elav-like gene, which we designated elr-1. The elr-1 gene encodes a predicted 456-amino-acid protein containing three putative RNA-binding domains and belongs to the ELAV family, which is functionally involved in neuronal differentiation. Northern blo...

journal_title：Biochemical and biophysical research communications

authors： Fujita M,Kawano T,Ohta A,Sakamoto H

更新日期：1999-07-14 00:00:00

abstract：:We have isolated mouse cDNA clones that encode a newly discovered collagenous polypeptide. Four overlapping cDNA clones contained an open reading frame of 1140 amino acid residues of collagenous and non-collagenous domains. The predicted polypeptide consists of 10 collagenous domains of various length that are interru...

journal_title：Biochemical and biophysical research communications

authors： Abe N,Muragaki Y,Yoshioka H,Inoue H,Ninomiya Y

更新日期：1993-10-29 00:00:00

abstract：:The development of rational methods to design 'continuous' sequence mimetics of discontinuous regions of protein sequence has, to now, been only marginally successful. This has been largely due to the difficulty of constraining the recognition elements of a mimetic structure to the relative conformational and spatial ...

journal_title：Biochemical and biophysical research communications

authors： Casset F,Roux F,Mouchet P,Bes C,Chardes T,Granier C,Mani JC,Pugnière M,Laune D,Pau B,Kaczorek M,Lahana R,Rees A

更新日期：2003-07-18 00:00:00

abstract：:Cells of the monocyte series respond to follicle stimulating hormone (FSH) by poorly characterized mechanisms. We studied FSH-receptors (FSH-R) and FSH response in nontransformed human monocytes and in osteoclasts differentiated from these cells. Western blot and PCR confirmed FSH-R expression on monocytes or osteocla...

journal_title：Biochemical and biophysical research communications

authors： Robinson LJ,Tourkova I,Wang Y,Sharrow AC,Landau MS,Yaroslavskiy BB,Sun L,Zaidi M,Blair HC

更新日期：2010-03-26 00:00:00

abstract：:The causative agent of Lyme disease, Borrelia burgdorferi, requires shifts in gene expression to undergo its natural enzootic cycle between tick and vertebrate hosts. mRNA decay mechanisms play significant roles in governing gene expression in other bacteria, but are not yet characterized in B. burgdorferi. RNase III ...

journal_title：Biochemical and biophysical research communications

authors： Snow S,Bacon E,Bergeron J,Katzman D,Wilhelm A,Lewis O,Syangtan D,Calkins A,Archambault L,Anacker ML,Schlax PJ

更新日期：2020-08-20 00:00:00

abstract：:Cell adhesion molecules of human dermal fibroblasts play an important role in the processes of wound healing. The effects of tumor necrosis factor- alpha (TNF) on the expression of integrin beta 1 subfamily in human dermal fibroblasts were examined. TNF preferentially induced the expression of alpha 2 beta 1 integrins...

journal_title：Biochemical and biophysical research communications

authors： Ezoe K,Horikoshi T

更新日期：1993-04-15 00:00:00

abstract：:The expression of the ibpAibpB heat-shock operon of Escherichia coli was found previously not to conform to the known pattern of expression of the sigma(32)-regulated operons because the rpoH gene mutation inactivating the sigma(32) protein did not abolish the ibp induction. We show here that this effect can depend pa...

journal_title：Biochemical and biophysical research communications

authors： Kuczyńska-Wisńik D,Laskowska E,Taylor A

更新日期：2001-06-01 00:00:00

abstract：:The bridging element for electron transfer in proteins is the hydrogen bond according to the new experimental perspective in preference to carbon-carbon σ-bond presently used. The purpose of this study is to identify an alternative pathway linked by hydrogen bonds suitable for electron transfer from heme-Fe of cytochr...

journal_title：Biochemical and biophysical research communications

authors： Ramasarma T,Vaigundan D

更新日期：2018-10-28 00:00:00

abstract：:Sakuranetin (5,4'-dihydroxy-7-methoxyflavone) belongs to the flavanone class of polyphenols predominantly known as phytoalexin in rice plant. In this study, we demonstrate that sakuranetin strongly induces differentiation of 3T3-L1 preadipocytes, as evidenced by increased triglyceride accumulation and glycerol-3-phosp...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Abe D,Sekiya K

更新日期：2008-08-08 00:00:00

abstract：:Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts. Stem cell factor exists as both a soluble and a membrane-bound glycoprotein while Kit...

journal_title：Biochemical and biophysical research communications

authors： Roskoski R Jr

更新日期：2005-12-23 00:00:00

abstract：:Adhesive ascidians have caused serious biofouling problems and huge economic losses in marine ecosystems. However, adhesion mechanisms, particularly on functional proteins involved in ascidian adhesion, remain largely unexplored. Here, we identified 26 representative stolon proteins from the highly invasive fouling as...

journal_title：Biochemical and biophysical research communications

authors： Li S,Huang X,Chen Y,Li X,Zhan A

更新日期：2019-02-26 00:00:00

abstract：:We have developed a DNA vaccine encoding a fusion protein of ubiquitin (Ub) and target proteins at the N-terminus for effective induction of antigen-specific CD8(+) T cells. A series of expression plasmids encoding a model antigen, ovalbumin (OVA), fused with mutated Ub, was constructed. Western blotting analyses usin...

journal_title：Biochemical and biophysical research communications

authors： Imai T,Duan X,Hisaeda H,Himeno K

更新日期：2008-01-25 00:00:00

abstract：:Kallikrein 7 (hK7), a chymostatin-like serine protease, is overexpressed in pancreatic adenocarcinomas as well as other human cancers. Although it has been demonstrated to participate in normal desquamation by facilitating cell shedding at the skin surface, its role in human malignancies remains unclear. To investigat...

journal_title：Biochemical and biophysical research communications

authors： Ramani VC,Haun RS

更新日期：2008-05-16 00:00:00

abstract：:Capsaicin has been reported to regulate blood glucose levels and to ameliorate insulin resistance in obese mice. This study demonstrates that capsaicin increases glucose uptake directly by activating AMP-activated protein kinase (AMPK) in C2C12 muscle cells, which manifested as an attenuation of glucose uptake when co...

journal_title：Biochemical and biophysical research communications

authors： Kim SH,Hwang JT,Park HS,Kwon DY,Kim MS

更新日期：2013-09-13 00:00:00

abstract：:Ubiquitin (Ub) carboxyl-terminal hydrolase L1 (UCH-L1) has dual functions, such as hydrolase activity on the chemical bonds formed by the C-terminal Gly of Ub and dimerization-dependent ubiquitin ligase activity. Accumulating evidence suggests that dual activities of UCH-L1 were intimately associated with Parkinson's ...

journal_title：Biochemical and biophysical research communications

authors： Park DW,Nam MK,Rhim H

更新日期：2011-11-11 00:00:00

abstract：:Immature secretory granules (ISG's) are sites of segregation of proteins destined for secretion by unregulated pathways from those stored in mature secretory granules in endocrine cells. To determine whether significant soluble protein sorting occurs in ISG's, the secretion of soluble versions of the pancreatic protei...

journal_title：Biochemical and biophysical research communications

authors： Rindler MJ,Colomer V,Jin Y

更新日期：2001-11-16 00:00:00

abstract：:During adipocyte differentiation, CCAAT/enhancer-binding protein alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of numerous adipocyte genes. The promoter of the C/EBPalpha gene has an E-box upstream of C/EBP binding site. Deletion or mutation of the E-box decreases promoter activity, suggestin...

journal_title：Biochemical and biophysical research communications

authors： Kim JW,Monila H,Pandey A,Lane MD

更新日期：2007-03-09 00:00:00

abstract：:Diallyl trisulfide (DATS), one of the volatile constituents of garlic oil, has been reported to possess antioxidant, anti-inflammatory, and anti-carcinogenic properties. In this study, DATS (10μmol) given orally for 7days before and for another 7days after starting administration of 2.5% dextran sulfate sodium (DSS) i...

journal_title：Biochemical and biophysical research communications

authors： Lee HJ,Lee HG,Choi KS,Surh YJ,Na HK

更新日期：2013-07-26 00:00:00

abstract：:The solubilized [3H]ryanodine receptor from cardiac sarcoplasmic reticulum was centrifuged through linear sucrose gradients. A single peak of radioactivity with apparent sedimentation coefficient of approximately 30S specifically comigrated with a high molecular weight protein of apparent relative molecular mass appro...

journal_title：Biochemical and biophysical research communications

authors： Lai FA,Anderson K,Rousseau E,Liu QY,Meissner G

更新日期：1988-02-29 00:00:00

abstract：:The effect of ochratoxin A on the specific activities of phosphoenolpyruvate carboxykinase, gamma-glutamyl transpeptidase and phosphate-dependent glutaminase were investigated in primary cultures of rat kidney proximal convoluted tubule cells grown in a serum-free medium supplemented with growth factors. Addition of o...

journal_title：Biochemical and biophysical research communications

authors： Thekkumkara TJ,Patel MS

更新日期：1989-08-15 00:00:00

abstract：:Voltage-dependent anion channel (VDAC) is a multi-functional channel protein in the mitochondrial outer membrane of all eukaryotes. It is involved in extensive physiological and pathophysiological processes. However there is only scant information about VDAC in mammalian reproduction, fertility and development in the ...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Zhang W,Wang Z

更新日期：2010-07-09 00:00:00

abstract：:Phenylenediamine derivatives can function as a hydrogen donor and reportedly exert various biological actions including cytoprotective effects against oxidative stress, possibly by acting as an antioxidant. Previous studies showed that feeding of such compounds to mice reduced their body weight, but the precise mechan...

journal_title：Biochemical and biophysical research communications

authors： Yanagitai M,Kitagawa T,Okawa K,Koyama H,Satoh T

更新日期：2012-01-06 00:00:00

abstract：:Thyroid hormone (T3) responsiveness of the PEPCK promoter in vivo was examined in both PEPCK/bGH(460) and PEPCK/bGH(335) mouse lines. Transgenic and non-transgenic littermates were treated with methimazole or PTU for 6 or 4 weeks, respectively, then treated +/- T3 for 10 days. In PEPCK/bGH(460) and PEPCK/bGH(355) tran...

journal_title：Biochemical and biophysical research communications

authors： Xu C,McGrane MM

更新日期：1996-01-17 00:00:00

abstract：:Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system and is mediated by complement-dependent cytotoxicity (CDC) of NMO-specific immunoglobulin G (IgG) antibodies (NMO-IgG). Glycyrrhizic acid (GA) has numerous pharmacological effects including inhibition of the complement pa...

journal_title：Biochemical and biophysical research communications

authors： Kim JS,Cheon S,Kim SW,Kim B,Kim H,Park KD,Kim SM

更新日期：2016-09-16 00:00:00

abstract：:Inflammation has been postulated as a risk factor for several cancers. 3-Nitrotyrosine is a biochemical marker for inflammation. We investigated the ability of nitrotyrosine and nitrotyrosine-containing peptides (nitroY-peptide) to induce DNA damage by the experiments using 32P-labeled DNA fragments obtained from the ...

journal_title：Biochemical and biophysical research communications

authors： Murata M,Kawanishi S

更新日期：2004-03-26 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) has recently been described to induce antimycobacterial activity. The present study analyses the role played by S1P in antigen presentation of monocytes and in the next activation of Mycobacterium tuberculosis (MTB)-specific CD4+ T cell response. Results reported herein show that S1P stim...

journal_title：Biochemical and biophysical research communications

authors： Santucci MB,Greco E,De Spirito M,Arcovito G,De Angelis G,Cauda R,Fraziano M

更新日期：2007-09-28 00:00:00

abstract：:A baculovirus expression system has been used to express large quantities of full-length, biologically active Xenopus fibroblast growth factor receptor-1. Recombinant XFGFR-1 was purified to near homogeneity by a single step immunoaffinity purification procedure. The recombinant XFGFR-1 binds both FGF-1 and FGF-2 with...

journal_title：Biochemical and biophysical research communications

authors： Brown SA,Friesel R

更新日期：1993-06-30 00:00:00