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NSAIDs acutely inhibit TRPC channels in freshly isolated rat glomeruli.

Abstract：

:Using a novel approach for analysis of TRPC channel activity, we report here that NSAIDs are involved into regulation of TRPC channels in the podocytes of the freshly isolated decapsulated glomeruli. Fluorescence and electron microscopy techniques confirmed the integrity of podocytes in the glomeruli. Western blotting showed that TRPC1, 3 and 6 are highly expressed in the glomeruli. Single-channel patch clamp analysis revealed cation currents with distinct TRPC properties. This is the first report describing single TRPC-like currents in glomerular podocytes. Furthermore, our data provide a novel mechanism of NSAIDs regulation of TRPC channels, which might be implicated in maintaining the glomerular filtration barrier.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ilatovskaya DV,Levchenko V,Ryan RP,Cowley AW Jr,Staruschenko A

doi

10.1016/j.bbrc.2011.04.005

subject

Has Abstract

pub_date

2011-05-06 00:00:00

pages

242-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)00568-7

journal_volume

408

pub_type

杂志文章

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