当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters.

Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters.

Abstract：

:Expression of human inducible nitric oxide synthase (hiNOS) is under cytokine control and is transcriptionally regulated. The hiNOS and mouse iNOS (miNOS) genes are regulated differently by cytokines. To understand better the transcriptional regulation of the hiNOS gene, the 8.3-kb hiNOS promoter was characterized. Promoter activity was evaluated by transient transfection of hiNOS luciferase constructs in A549 human alveolar type II epithelium-like cells in the presence and absence of cytokines (IFN-gamma, IL-1 beta, and TNF-alpha). Important cytokine-responsive elements are located at -3665 to -5574 bp (containing two perfectly matched AP-1 sites which are not present in miNOS promoter) and -8093 to -8296 bp (one perfectly matched NF-kappa B site) of the hiNOS promoter region. Likely, these two AP-1 sites and the upstream NF-kappa B site are important in the transcriptional induction of hiNOS by cytokines. Our data demonstrate the molecular basis for the different cytokine-stimulated characteristics of hiNOS and miNOS genes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chu SC,Marks-Konczalik J,Wu HP,Banks TC,Moss J

doi

10.1006/bbrc.1998.9062

subject

Has Abstract

pub_date

1998-07-30 00:00:00

pages

871-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)99062-3

journal_volume

248

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • KLHL2 interacts with and ubiquitinates WNK kinases.

    abstract：:Mutations in the WNK1 and WNK4 genes result in an inherited hypertensive disease, pseudohypoaldosteronism type II (PHAII). Recently, the KLHL3 and Cullin3 genes were also identified as responsible genes for PHAII. Although we have reported that WNK4 is a substrate for the KLHL3-Cullin3 E3 ligase complex, it is not cle...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.06.104

    authors： Takahashi D,Mori T,Wakabayashi M,Mori Y,Susa K,Zeniya M,Sohara E,Rai T,Sasaki S,Uchida S

    更新日期：2013-08-02 00:00:00

  • Deduction of upstream sequences of Xanthomonas campestris flagellar genes responding to transcription activation by FleQ.

    abstract：:Xanthomonas campestris pv. campestris (Xcc), a close relative to Pseudomonas aeruginosa, is the pathogen causing black rot in cruciferous plants. In P. aeruginosa, FleQ serves as a cognate activator of sigma54 in transcription from several sigma54-dependent promoters of flagellar genes. These P. aeruginosa promoters h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.171

    authors： Hu RM,Yang TC,Yang SH,Tseng YH

    更新日期：2005-10-07 00:00:00

  • AJAP1 affects behavioral changes and GABABR1 level in epileptic mice.

    abstract：:Adherens junction-associated protein-1 (AJAP1), also called SHREW1, was first discovered as a novel component of adherens junctions in 2004. In later studies, AJAP1 was found to suppress invasion and predict recurrence of some tumors. Apart from its function as a putative tumor suppressor, AJAP1 is still poorly unders...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.036

    authors： Zhang M,Zhou X,Jiang W,Li M,Zhou R,Zhou S

    更新日期：2020-04-16 00:00:00

  • Study of an antiestrogenic effect of retinoic acid in MCF-7 cells.

    abstract：:We recently developed the cellular model MVLN-15 in which estrogenic action can be detected by bioluminescence. Using this cellular model, we characterized the inhibitory effect of retinoic acid on the estrogen-dependent induction of luciferase transcription. We present evidence that i) the inhibitory effect of retino...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91614-v

    authors： Demirpence E,Pons M,Balaguer P,Gagne D

    更新日期：1992-02-28 00:00:00

  • Ser-261 phospho-regulation is involved in pS256 and pS269-mediated aquaporin-2 apical translocation.

    abstract：:Vasopressin catalyzes aquaporin-2 phosphorylation at several serine sites in the C-terminal region. Compared with Ser-256 and Ser-269 phosphorylation, the role of Ser-261 phospho-regulation on vasopressin-regulated AQP2 apical translocation is largely unknown. In addition, recent discovery of transcytotic apical deliv...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.162

    authors： Yui N,Ando F,Sasaki S,Uchida S

    更新日期：2017-08-26 00:00:00

  • Phorbol ester treatment inhibits thrombin but not stable GTP analogue-induced platelet granule secretion despite inhibition of phosphatidate formation with both agonists.

    abstract：:Previous work has demonstrated that pre-treatment of platelets with phorbol esters that activate protein kinase C eg phorbol 12-myristate 13-acetate (PMA) results in an inhibition of inositol phospholipid breakdown and granule secretion induced by physiological agonists such as thrombin and collagen. In the present st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80768-x

    authors： Krishnamurthi S,Kakkar VV

    更新日期：1988-11-15 00:00:00

  • Stretching mesangial cells stimulates tyrosine phosphorylation of focal adhesion kinase pp125FAK.

    abstract：:Mechanical loading of cultured mesangial cells has been shown to induce both increased production of matrix proteins and cell proliferation. This in vitro phenomenon has been implicated in the progression of glomerular sclerosis observed in a variety of glomerular diseases. However, it is not yet known how cells sense...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2004

    authors： Hamasaki K,Mimura T,Furuya H,Morino N,Yamazaki T,Komuro I,Yazaki Y,Nojima Y

    更新日期：1995-07-17 00:00:00

  • Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein.

    abstract：:The molecular mechanism of the phosphorylation-dependent activation of tryptophan hydroxylase is studied with respect to the role of the 14-3-3 protein. Reexamination of the system reconstituted with the purified TRH and the 14-3-3 protein showed that the level of the TRH activity correlated with the extent of the Ca2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1796

    authors： Furukawa Y,Ikuta N,Omata S,Yamauchi T,Isobe T,Ichimura T

    更新日期：1993-07-15 00:00:00

  • Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.

    abstract：:The three genes that form the UGA regulon in Saccharomyces cerevisiae are responsible for the transport and degradation of γ-aminobutyric acid (GABA) in this organism. Despite the differences in the sequence of their promoters, these genes similarly respond to GABA stimuli. The expression of UGA1, UGA2 and UGA4 depend...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.086

    authors： Cardillo SB,Correa García S,Bermúdez Moretti M

    更新日期：2011-07-15 00:00:00

  • Transforming growth factor-beta inhibits endothelial cell proliferation.

    abstract：:Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91209-x

    authors： Fràter-Schröder M,Müller G,Birchmeier W,Böhlen P

    更新日期：1986-05-29 00:00:00

  • Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene.

    abstract：:To clarify the mechanism of transcriptional induction of the rat liver acyl-CoA oxidase gene by hypolipidemic agents, we searched for cis-acting regulatory sequences in the 5' upstream region of the gene by transfection studies. We found that the sequence between -639 and -472 acts as a peroxisome proliferator-respons...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91645-s

    authors： Osumi T,Wen JK,Hashimoto T

    更新日期：1991-03-29 00:00:00

  • Identification of an unconventional nuclear localization signal in human ribosomal protein S2.

    abstract：:Ribosomal proteins must be imported into the nucleus after being synthesized in the cytoplasm. Since the rpS2 amino acid sequence does not contain a typical nuclear localization signal, we used deletion mutant analysis and rpS2-beta-galactosidase chimeric proteins to identify the nuclear targeting domains in rpS2. Nuc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.069

    authors： Antoine M,Reimers K,Wirz W,Gressner AM,Müller R,Kiefer P

    更新日期：2005-09-16 00:00:00

  • Poly(rC)-binding protein 2 interacts with the oligo(rC) tract of coxsackievirus B3.

    abstract：:The human poly(rC)-binding protein (PCBP) 2 is known to interact with enteroviral RNA. Here, the interaction of PCBP2 with RNA target sequences at the 5' end of the coxsackievirus B3 genome was investigated. Using the electrophoretic mobility shift assay and the yeast three-hybrid system, a short oligo(rC) tract conne...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.038

    authors： Zell R,Ihle Y,Seitz S,Gündel U,Wutzler P,Görlach M

    更新日期：2008-02-22 00:00:00

  • Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase.

    abstract：:For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hyd...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91438-x

    authors： De Clercq E,Cools M

    更新日期：1985-05-31 00:00:00

  • Implanting mouse embryo stain with a LNF-I bearing fluorescent probe at their mural trophectodermal side.

    abstract：:Mouse embryos at implantation stage were stained successfully with lacto-N-fucopentaose I (LNF-I) bearing neoglycoprotein labeled with rhodamine synthesized by us for the first time. The fluorescent neoglycoproteins carrying LNF-II, -III, LND-I, or LNT failed to stain the embryos. The embryo was stained only at the ce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)92036-j

    authors： Yamagata T,Yamazaki K

    更新日期：1991-12-31 00:00:00

  • Amblyomma americanum salivary gland homolog of nSec1 is essential for saliva protein secretion.

    abstract：:Soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins assemble in tight core complexes which promote fusion of carrier vesicles with target compartments. Members of this class of proteins are expressed in all eukaryotic cells and distributed in distinct subcellular compartments. All vesicle tr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.189

    authors： Karim S,Ramakrishnan VG,Tucker JS,Essenberg RC,Sauer JR

    更新日期：2004-11-26 00:00:00

  • Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats.

    abstract：:Nuclei of the dorsolateral prostate of rats contain a large amount of androgen-dependent non-histone protein (20K-NHP) (mol. wt. not equal to 20,000; pI not equal to 11.5) (Matuo et al. (1]. Its content in the nuclei increased most markedly during 4-8 weeks of age, when functional differentiation of the prostate was m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91326-3

    authors： Matuo Y,Nishi N,Tanaka Y,Muguruma Y,Tanaka K,Akatsuka Y,Matsui SI,Sandberg AA,Wada F

    更新日期：1984-01-30 00:00:00

  • Prediction of pi-turns in proteins using PSI-BLAST profiles and secondary structure information.

    abstract：:Due to the structural and functional importance of tight turns, some methods have been proposed to predict gamma-turns, beta-turns, and alpha-turns in proteins. In the past, studies of pi-turns were made, but not a single prediction approach has been developed so far. It will be useful to develop a method for identify...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.066

    authors： Wang Y,Xue ZD,Shi XH,Xu J

    更新日期：2006-09-01 00:00:00

  • Isolation and characterization of iso-rANP, a new natriuretic peptide from rat atria.

    abstract：:Using a specific radioimmunoassay we have isolated and sequenced a new 45-amino acid peptide from rat atria which exhibits similar physiological and pharmacological properties to rat atrial natriuretic peptide (rANP). We have termed the new peptide iso-rANP, because of its functional and structural similarities to rAN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92675-2

    authors： Flynn TG,Brar A,Tremblay L,Sarda I,Lyons C,Jennings DB

    更新日期：1989-06-15 00:00:00

  • Hypertonic induction of COX2 expression requires TonEBP/NFAT5 in renal epithelial cells.

    abstract：:TonEBP/NFAT5 transcription factor is a master regulator of genes involved in osmoprotection. Cyclooxygenase 2 (COX2) has been reported to be a cytoprotective molecule in the inner renal medulla, where cells are physiologically exposed to the highest osmolality of the body. Our aim was to study whether COX2 expression ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.189

    authors： Favale NO,Casali CI,Lepera LG,Pescio LG,Fernández-Tome MC

    更新日期：2009-04-10 00:00:00

  • High resolution structure of Vibrio cholerae acylphosphatase (VcAcP) cage: Identification of drugs, location of its binding site and engineering to facilitate cage formation.

    abstract：:Protein cages have recently emerged as an extraordinary drug-delivery system due to its biocompatibility, biodegradability, low toxicity, ease to manipulate and engineer. We have reported earlier the formation and architecture of a do-decameric cage-like architecture of Vibrio cholerae acylphosphatase (VcAcP) at 3.1 Å...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.12.060

    authors： Chatterjee S,Nath S,Sen U

    更新日期：2020-03-05 00:00:00

  • Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway.

    abstract：:Pancreatic adenocarcinoma is characterized by an intense desmoplastic reaction that surrounds the tumor. Pancreatic stellate cells (PSCs) are thought to be responsible for production of this extracellular matrix. When activated, PSCs have a myofibroblast phenotype and produce not only components of the extracellular m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.229

    authors： Yoshida S,Yokota T,Ujiki M,Ding XZ,Pelham C,Adrian TE,Talamonti MS,Bell RH Jr,Denham W

    更新日期：2004-10-29 00:00:00

  • Evidence of L-arginine/nitric oxide pathway in endothelium and smooth muscle of human internal mammary artery.

    abstract：UNLABELLED:The L-arginine-nitric oxide (NO) pathway was investigated in human internal mammary artery (HIMA) in vitro. HIMA rings were mounted in organ bath, and then incubated in Krebs buffer for 1 to 8 hrs, relaxing agents were tested. Under these conditions, L-arginine (0.1 microM - 1 mM) elicited only minor relaxat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2014

    authors： Qi X,Chen D,Nottin R,Mace L,Herve P,Weiss M

    更新日期：1993-08-31 00:00:00

  • Proteins that bind to the RERMS region of beta amyloid precursor protein.

    abstract：:The main objective of this study was to investigate the biological function of beta amyloid precursor protein (APP), in particular its nerve growth factor-like activity. We hypothesize that the extracellular domain containing the sequence RERMS, amino acids 328-332 of APP(695), represents the active site for this func...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.02.047

    authors： Pawlik M,Otero DA,Park M,Fischer WH,Levy E,Saitoh T

    更新日期：2007-04-20 00:00:00

  • Crystal structure of the sweet-tasting protein thaumatin II at 1.27Å.

    abstract：:Thaumatin, an intensely sweet-tasting protein, elicits a sweet taste sensation at 50 nM. Here the X-ray crystallographic structure of one of its variants, thaumatin II, was determined at a resolution of 1.27 Å. Overall structure of thaumatin II is similar to thaumatin I, but a slight shift of the Cα atom of G96 in tha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.158

    authors： Masuda T,Ohta K,Tani F,Mikami B,Kitabatake N

    更新日期：2011-07-08 00:00:00

  • Regulation of tight junction permeability by sodium caprate in human keratinocytes and reconstructed epidermis.

    abstract：:Tight junctions (TJs) restrict paracellular flux of water and solutes in epithelia and endothelia. In epidermis, the physiological role of TJs is not fully understood. In this study, sodium caprate (C10), which dilates intestinal TJs, was applied to cultured human epidermal keratinocytes and reconstructed human epider...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.02.005

    authors： Kurasawa M,Kuroda S,Kida N,Murata M,Oba A,Yamamoto T,Sasaki H

    更新日期：2009-04-03 00:00:00

  • N-methyl-N-nitrosourea evidences cell cycle associated transient sequences in hepatic replicating DNA.

    abstract：:Experiments of molecular hybridization were carried out with the aim of singling out DNA sequences which might be important in the hepatocarcinogenic action of N-methyl-N-nitrosourea. Results were obtained suggesting the synthesis of transitory DNA sequences during compensatory cell proliferation. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1367

    authors： Kanduc D

    更新日期：1995-03-17 00:00:00

  • Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites.

    abstract：:We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E2F-bindi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.02.081

    authors： Kim S,Kang JK,Kim YK,Seo DW,Ahn SH,Lee JC,Lee CH,You JS,Cho EJ,Lee HW,Han JW

    更新日期：2006-04-21 00:00:00

  • A novel expression vector for the improved solubility of recombinant scorpion venom in Escherichia coli.

    abstract：:Recombinant scorpion anti-excitation peptide (rANEP) has previously been expressed using the pET32a system and purified via affinity chromatography. However, rANEP is expressed in BL21(DE3) cells as an inclusion body, and the affinity tag can not be removed. To overcome this problem, we used a variety of protein, DsbA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.09.047

    authors： Han T,Ming H,Deng L,Zhu H,Liu Z,Zhang J,Song Y

    更新日期：2017-01-01 00:00:00

  • The stimulation of prostaglandin production by transforming growth factor-alpha and 12-O-tetradecanoyl-phorbol-13-acetate or 1-oleoyl-2-acetyl-glycerol is synergistic.

    abstract：:Stimulation of prostaglandin production in C-9 rat liver cells by transforming growth factor (TGF)-alpha was synergistic with that of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). TGF-alpha and TPA synergized the release of radiolabelled compounds from [3H]arachidonic acid prelabelled C-9 cells. 1-Ol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90389-4

    authors： Levine L,Xiao DM,Worth N,Lilley WE

    更新日期：1985-07-16 00:00:00