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Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.

Abstract：

:The three genes that form the UGA regulon in Saccharomyces cerevisiae are responsible for the transport and degradation of γ-aminobutyric acid (GABA) in this organism. Despite the differences in the sequence of their promoters, these genes similarly respond to GABA stimuli. The expression of UGA1, UGA2 and UGA4 depends on GABA induction and nitrogen catabolite repression (NCR). The induction of these genes requires the action of at least two positive proteins, the specific Uga3 and the pleiotropic Uga35/Dal81 transcription factors. Here we show that all the members of the UGA regulon, as was already demonstrated for UGA4, are negatively regulated by extracellular amino acids through the SPS amino acid sensor. We also show that this negative effect is caused by a low availability of Uga35/Dal81 transcription factor and that Leu3 transcription factor negatively regulates UGA4 and UGA1 expression but it does not affect UGA2 expression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cardillo SB,Correa García S,Bermúdez Moretti M

doi

10.1016/j.bbrc.2011.06.086

subject

Has Abstract

pub_date

2011-07-15 00:00:00

pages

885-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)01066-7

journal_volume

410

pub_type

杂志文章

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