Effect of green tea polyphenols on angiogenesis induced by an angiogenin-like protein.

abstract：:The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

journal_title：Biochemical and biophysical research communications

authors： Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

更新日期：1992-10-15 00:00:00

abstract：:PU.1 is a transcription factor found in macrophages, B cells, neutrophils, and hemopoietic stem cells. In macrophages PU.1 regulates a number of genes, including c-fms, CD11b, CD18, and FcgammaR1b. Previously, in primary macrophages PU.1 binding to the sequence GAGGAA was found to be induced by treatment with bacteria...

journal_title：Biochemical and biophysical research communications

authors： Xue Y,Alford P,Shackelford RE

更新日期：1999-01-08 00:00:00

abstract：:1,2-Naphthoquinone (1,2-NQ) is an atmospheric contaminant with electrophilic properties that allow it to react readily with protein thiol groups such as those found on the cAMP response element-binding protein (CREB), a transcription factor with conserved cysteine residues that regulate DNA binding. In the present stu...

journal_title：Biochemical and biophysical research communications

authors： Endo A,Sumi D,Kumagai Y

更新日期：2007-09-14 00:00:00

abstract：:Whereas sitosterol and 24(28)-methylene cycloartanol were competitive inhibitors (with Ki = 26 microM and 14 microM, respectively), 24(R,S)-25-epiminolanosterol was found to be a potent non-competitive inhibitor (Ki = 3.0 nM) of the S-adenosyl-L-methionine-C-24 methyl transferase from sunflower embryos. Because the gr...

journal_title：Biochemical and biophysical research communications

authors： Nes WD,Janssen GG,Norton RA,Kalinowska M,Crumley FG,Tal B,Bergenstrahle A,Jonsson L

更新日期：1991-05-31 00:00:00

abstract：:Lipoprotein lipase (LPL) bound to vascular endothelial cells hydrolyses triglycerides in plasma lipoproteins. To explore the role of LPL in atherogenesis, the effect of LPL-mediated lipolysis of very low density lipoproteins (VLDL) on monocyte adhesion to endothelial cells was examined. Adhesion of U937 monocytes to p...

journal_title：Biochemical and biophysical research communications

authors： Saxena U,Kulkarni NM,Ferguson E,Newton RS

更新日期：1992-12-30 00:00:00

abstract：:Dietary supplementation with coenzyme Q (CoQ) has been proposed to have anti-atherogenic effects by virtue of its antioxidant capacity. To investigate this question, the leukocyte status of 5 males and 5 females (52-68 years) was evaluated before and after supplementation with 200mg CoQ/day for 5 and 10 weeks. CoQ was...

journal_title：Biochemical and biophysical research communications

authors： Turunen M,Wehlin L,Sjöberg M,Lundahl J,Dallner G,Brismar K,Sindelar PJ

更新日期：2002-08-16 00:00:00

abstract：:This study aims to investigate the clinical significance and biological function of RASSF6 in human breast cancers. RASSF6 protein was found to be downregulated in 42 of 95 human breast cancer tissues by immunohistochemistry, which was associated with advanced TNM stage and nodal metastasis. The rate of RASSF6 downreg...

journal_title：Biochemical and biophysical research communications

authors： He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

更新日期：2018-09-18 00:00:00

abstract：:The purpose of this study was to elucidate the involvement of H2O2 production in cisplatin-induced nephrotoxicity. The S3 cells were more sensitive than OMCT cells in cell viability and H2O2 production during cisplatin treatment. The cytotoxicity and H2O2 production induced by cisplatin were terminated by treatment wi...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumishita Y,Onda T,Okada K,Takeda M,Endou H,Futaki S,Niwa M

更新日期：1998-01-14 00:00:00

abstract：:Ophiopogonin D (OPD) is the chief pharmacological active component of the traditional Chinese herbal prescription drug-Shenmai injection (SMI), which has been used to prevent and treat cardiovascular diseases. In the present study, we investigated whether OPD protectively relieve cardiac hypertrophy against inflammati...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang X,Ma Z,Wang Y,Chen X,Gao Y

更新日期：2018-09-05 00:00:00

abstract：:1-4 interaction scaling factors are used in AMBER forcefields to reduce the exaggeration of short-range repulsion caused by the 6-12 Lennard-Jones potential and a nonpolarizable charge model and to obtain better agreements of small-molecule conformational energies with experimental data. However, the effects of these ...

journal_title：Biochemical and biophysical research communications

authors： Pang YP

更新日期：2015-02-06 00:00:00

abstract：:Toll-like receptors (TLRs) are important initiators in innate immune responses against pathogenic microbes such as viruses, intracellular bacteria or parasites. Although the innate immune system is designed to fight infectious pathogens, excessive activation of TLR signaling may lead to unwarranted inflammation with h...

journal_title：Biochemical and biophysical research communications

authors： Liu J,Zhang Z,Chai L,Che Y,Min S,Yang R

更新日期：2013-04-26 00:00:00

abstract：:Long repeated stretches of d(CCG) and tri-nucleotide are crucial mutations that cause hereditary forms of mental retardation (fragile X-syndrome). Moreover, the alternating (CG) di-nucleotide is one of the candidates for Z-DNA conformation. Solution NMR structure of d(CCGCGG)(2) has been solved and is discussed. The d...

journal_title：Biochemical and biophysical research communications

authors： Monleón D,Esteve V,Celda B

更新日期：2003-03-28 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) is upregulated in many cancers, especially neuroblastoma. We set out to explore whether geranylgeranoic acid (GGA) inhibits LSD1 activity by using recombinant human LSD1. GGA inhibited LSD1 activity with IC50 similar to that of the clinically used drug tranylcypromine. In human neu...

journal_title：Biochemical and biophysical research communications

authors： Sakane C,Okitsu T,Wada A,Sagami H,Shidoji Y

更新日期：2014-01-31 00:00:00

abstract：:Characterization of functional vessels is required either for monitoring hemodynamics or patterning of functional vasculature in experimental models. Haemoglobin (Hb) staining is a traditionally used approach for determining the differentiation of erythroid cells. In this investigation, we tested if HB staining can be...

journal_title：Biochemical and biophysical research communications

authors： Zheng PP,Severijnen LA,Willemsen R,Kros JM

更新日期：2009-03-20 00:00:00

abstract：:Pain is a common symptom of injuries and inflammatory-related conditions. The perception of pain, commonly known as nociception, depends on integrated receptors and molecular pathways. Inflammatory mediators are involved in the genesis, persistence, and severity of pain. Noxious stimuli can trigger a cascade of inflam...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2007-02-09 00:00:00

abstract：:MicroRNAs (miRs) are small non-coding RNAs that regulate the target gene expression. A change in miR profile in the pancreatic islets during diabetes is known, and multiple studies have demonstrated that miRs influence the pancreatic β-cell function. The miR-204 is highly expressed in the β-cells and reported to regul...

journal_title：Biochemical and biophysical research communications

authors： Gaddam RR,Kim YR,Li Q,Jacobs JS,Gabani M,Mishra A,Promes JA,Imai Y,Irani K,Vikram A

更新日期：2020-11-05 00:00:00

abstract：:PILRα is an immune inhibitory receptor possessing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain enabling it to deliver inhibitory signals. Binding of PILRα to its ligand CD99 is involved in immune regulation; however, whether there are other PILRα ligands in addition to CD99 is not...

journal_title：Biochemical and biophysical research communications

authors： Kogure A,Shiratori I,Wang J,Lanier LL,Arase H

更新日期：2011-02-18 00:00:00

abstract：:MET, also known as hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase with an important role, both in normal cellular function as well as in oncogenesis. In many cancer types, abnormal activation of MET is related to poor prognosis and various strategies to inhibit its function, including small mo...

journal_title：Biochemical and biophysical research communications

authors： Humbert M,Medová M,Aebersold DM,Blaukat A,Bladt F,Fey MF,Zimmer Y,Tschan MP

更新日期：2013-02-08 00:00:00

abstract：:We examined the interactions of calmodulin with neuronal gap junction proteins connexin35 (Cx35) from perch, its mouse homologue Cx36, and the related perch Cx34.7 using surface plasmon resonance. Calmodulin bound to the C-terminal domains of all three connexins with rapid kinetics in a concentration- and Ca2+-depende...

journal_title：Biochemical and biophysical research communications

authors： Burr GS,Mitchell CK,Keflemariam YJ,Heidelberger R,O'Brien J

更新日期：2005-10-07 00:00:00

abstract：:Intercellular spaces between adjacent mucosal epithelial cells are sealed by tight junctions (TJs) that prevent the free movement of solutes across the epithelium. Claudins (CLs), a family of 27 integral membrane proteins, are essential components for TJ seals. We previously used a CL-3/-4 binder, the C-terminal fragm...

journal_title：Biochemical and biophysical research communications

authors： Matsuhisa K,Kondoh M,Suzuki H,Yagi K

更新日期：2012-06-29 00:00:00

abstract：:Human untranslated region (UTR) databases were searched to identify novel proteins potentially regulated by an iron responsive element (IRE), and found two candidates-cell cycle phosphatase Cdc14A variant 1 and myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCKalpha), both possessing a putative IRE in ...

journal_title：Biochemical and biophysical research communications

authors： Cmejla R,Petrak J,Cmejlova J

更新日期：2006-03-03 00:00:00

abstract：:Dendritic cells (DCs) pulsed with exosomes can stimulate efficient cytotoxic T-lymphocyte responses and anti-tumor immunity. However, the quantity of DC-derived exosomes (DCex) obtained from various culture systems is very low, which is a significant practical issue hampering progress in this research area and needs t...

journal_title：Biochemical and biophysical research communications

authors： Bu N,Wu H,Zhang G,Ma X,Zhao P,Zhai N,Xiang L,Cao H,Yang X,Liu J

更新日期：2015-01-02 00:00:00

abstract：:Ceramide kinase (CERK) produces the bioactive lipid ceramide 1-phosphate (C1P) and is, together with glucosylceramide synthase (GCS) and sphingomyelin synthases (SMS-1 and -2), a key regulator of ceramide metabolism. Here, we used a previously validated assay for measuring CERK, GCS, and SMS activities simultaneously,...

journal_title：Biochemical and biophysical research communications

authors： Rovina P,Graf C,Bornancin F

更新日期：2010-08-20 00:00:00

abstract：:Lipopolysaccharide (LPS) stimulates macrophages by activating NF-kappaB, which contributes to the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. 1,5-Anhydro-D-fructose (1,5-AF), a monosaccharide formed from starch and glycogen, exhibits anti-oxidant activity and enhances insulin secretion. This s...

journal_title：Biochemical and biophysical research communications

authors： Meng X,Kawahara K,Nawa Y,Miura N,Shrestha B,Tancharoen S,Sameshima H,Hashiguchi T,Maruyama I

更新日期：2009-03-06 00:00:00

abstract：:In this study, we investigated hybrid and non-hybrid actomyosin models including key contractile proteins: actin, myosin, and tropomyosin. These proteins were isolated from the rabbit skeletal muscle and the catch muscle of the mussel Crenomytilus grayanus. Our results confirmed literature data on an unusual ability o...

journal_title：Biochemical and biophysical research communications

authors： Shelud'ko NS,Vyatchin IG,Lazarev SS,Shevchenko UV

更新日期：2015-08-21 00:00:00

abstract：:Fractionation of a petroleum ether extract of Helianthus annuus L. led to the isolation of three diterpene acids: grandiflorolic, kaurenoic and trachylobanoic acids. These compounds were studied for potential anti-inflammatory activity on the generation of inflammatory mediators in lipopolysaccharide (LPS)-activated R...

journal_title：Biochemical and biophysical research communications

authors： Díaz-Viciedo R,Hortelano S,Girón N,Massó JM,Rodriguez B,Villar A,de Las Heras B

更新日期：2008-05-02 00:00:00

abstract：:As studied by intravital microscopy, local challenge with the mast cell secretagogue compound 48/80 was found to increase the leukocyte rolling fraction, decrease rolling velocity and induce firm leukocyte adhesion in postcapillary venules of the rat mesentery. These effects of compound 48/80 were inhibited by a monoc...

journal_title：Biochemical and biophysical research communications

authors： Thorlacius H,Raud J,Rosengren-Beezley S,Forrest MJ,Hedqvist P,Lindbom L

更新日期：1994-09-15 00:00:00

abstract：:Reactive oxygen species (ROS) play a crucial role in various physiological and pathological processes mediated by β-adrenergic receptors (β-ARs) in cardiomyocytes. However, the sources and signaling pathways involved in ROS production induced by acute β-AR activation have not yet been fully defined. In primary neonata...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Xiao H,Shen J,Wang N,Zhang Y

更新日期：2017-08-05 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] initiates the hydrolysis of sphingomyelin in ROS 17/2.8 osteosarcoma cells with the resultant generation of cell-associated ceramide. Increases in ceramide levels were detectable at 15 min and maximal one hour after exposure of cells to 1,25(OH)(2)D(3). Neither 1,25(OH)(2)D...

journal_title：Biochemical and biophysical research communications

authors： Liu R,Xu Y,Farach-Carson MC,Vogel JJ,Karin NJ

更新日期：2000-06-24 00:00:00

abstract：:By the determination of pyruvate dehydrogenase activity in tissue homogenates only limited information is gained on the actual metabolic flux. We therefore determined pyruvate decarboxylation in isolated rat hindlimbs non recirculating perfused with physiological (1-14C)pyruvate levels. On the basis of perfusate pyruv...

journal_title：Biochemical and biophysical research communications

authors： Schadewaldt P,Münch U,Prengel M,Staib W

更新日期：1983-10-31 00:00:00