Modulation of inflammatory responses by diterpene acids from Helianthus annuus L.

Abstract:

:Fractionation of a petroleum ether extract of Helianthus annuus L. led to the isolation of three diterpene acids: grandiflorolic, kaurenoic and trachylobanoic acids. These compounds were studied for potential anti-inflammatory activity on the generation of inflammatory mediators in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. At non-toxic concentrations, these compounds reduced, in a concentration-dependent manner nitric oxide (NO), prostaglandin E(2) (PGE(2)) and tumor necrosis factor (TNF-alpha) production, as well as expression of inducible nitric oxide synthase (NOS-2) and cyclooxygenase-2 (COX-2). All diterpenoids displayed significant in vivo anti-inflammatory activity and suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mouse ear edema. In addition, inhibition of myeloperoxidase (MPO) activity, an index of cellular infiltration, was observed. In summary, our results suggest that the inhibition of the expression of NOS-2, COX-2 and the release of inflammatory cytokines, is responsible for the anti-inflammatory effects of the diterpenoids isolated from H. annuus L. which likely contributes to the pharmacological action of sunflower.

authors

Díaz-Viciedo R,Hortelano S,Girón N,Massó JM,Rodriguez B,Villar A,de Las Heras B

doi

10.1016/j.bbrc.2008.02.104

subject

Has Abstract

pub_date

2008-05-02 00:00:00

pages

761-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00370-7

journal_volume

369

pub_type

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