Identification of the metal associated with the insulin degrading enzyme.

abstract：:The apicomplexan Toxoplasma gondii, an obligate intracellular parasite, can infect humans and a wide range of vertebrates. Following oral infection, the parasite invades tissues by crossing non-permissive biological barriers such as the placenta or the blood-brain barrier. But the molecular mechanisms underlying migra...

journal_title：Biochemical and biophysical research communications

authors： Buache E,Garnotel R,Aubert D,Gillery P,Villena I

更新日期：2007-07-27 00:00:00

abstract：:We explored the effect of transforming growth factor beta (TGF-beta), a cytokine that appears to play a central role in inflammatory events, on albumin expression by normal adult human hepatocytes and hepatoma cells. Addition of TGF-beta to primary human hepatocyte cultures resulted in a dramatic decrease in albumin a...

journal_title：Biochemical and biophysical research communications

authors： Busso N,Chesne C,Delers F,Morel F,Guillouzo A

更新日期：1990-09-14 00:00:00

abstract：:Histone chaperones function in histone transfer and regulate the nucleosome occupancy and the activity of genes. HIRA is a replication-independent (RI) histone chaperone that is linked to transcription and various developmental processes. Here, we show that HIRA interacts with Mef2 and contributes to the activation of...

journal_title：Biochemical and biophysical research communications

authors： Yang JH,Choi JH,Jang H,Park JY,Han JW,Youn HD,Cho EJ

更新日期：2011-04-15 00:00:00

abstract：:Due to the redundancy of the genetic code there exist six mRNA codons for arginine and several tRNA(Arg) isoacceptors which translate these triplets to protein within the context of the mRNA. The tRNA identity elements assure the correct aminoacylation of the tRNA with the cognate amino acid by the aminoacyl-tRNA-synt...

journal_title：Biochemical and biophysical research communications

authors： Eichert A,Perbandt M,Oberthür D,Schreiber A,Fürste JP,Betzel C,Erdmann VA,Förster C

更新日期：2009-07-17 00:00:00

abstract：:FIP-3 (NEMO/IKKgamma) is an essential modulator of the activity of NF-kappaB by mechanisms that include alterations in the phosphorylation, ubiquination, and degradation of IkappaBalpha. The multiple protein-protein interactions of FIP-3 (NEMO/IKKgamma) in a high molecular weight IKK complex indicated that this protei...

journal_title：Biochemical and biophysical research communications

authors： Tarassishin L,Horwitz MS

更新日期：2001-07-13 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) from normal adults secreted small amounts of human growth hormone (GH; 0.2-0.6 pg/10(5) cells/7 days culture) as measured by a highly sensitive enzyme immunoassay. Stimulation of PBMCs with phytohemagglutinin (PHA) consistently showed a 4-6 fold increase in GH secretion. Tran...

journal_title：Biochemical and biophysical research communications

authors： Hattori N,Shimatsu A,Sugita M,Kumagai S,Imura H

更新日期：1990-04-30 00:00:00

abstract：:Postmenopausal women treated with estrogen hormone replacement therapy and female patients with hypoplasminogenemia receiving oral contraceptives show increasing plasminogen (PLG) concentrations. The elevated PLG levels are in contrast to the estrogen dependent decline of lipoptrotein(a) [Lp(a)], whose main protein co...

journal_title：Biochemical and biophysical research communications

authors： Kobelt L,Klammt J,Tefs K,Schuster V

更新日期：2013-08-16 00:00:00

abstract：:To obtain antiparallel and parallel dimers of alpha-human atrial natriuretic peptide (alpha-hANP), two fully protected peptides I and II having the same amino acid sequence as alpha-hANP with different protective groups at the cysteinyl residues were synthesized, the former having Acm and Npys and the latter MeBzl and...

journal_title：Biochemical and biophysical research communications

authors： Chino N,Yoshizawa-Kumagaye K,Noda Y,Watanabe TX,Kimura T,Sakakibara S

更新日期：1986-12-15 00:00:00

abstract：:The CD133 antigen, identified as a hematopoietic stem cell marker, appears in various human embryonic epithelia including the neural tube, gut, and kidney. We herein investigated whether CD133(+) cells isolated from human hepatocellular carcinoma cell lines possess cancer stem/progenitor cell-like properties. Among th...

journal_title：Biochemical and biophysical research communications

authors： Suetsugu A,Nagaki M,Aoki H,Motohashi T,Kunisada T,Moriwaki H

更新日期：2006-12-29 00:00:00

abstract：:We have earlier reported changes in the GTP binding of several membrane proteins including Gs alpha and Gi alpha during thymic differentiation of T cells. Using an [alpha-32P]GTP-photoaffinity labeling technique we have studied the pattern of GTP binding proteins in activated and resting T lymphocytes and in T cells i...

journal_title：Biochemical and biophysical research communications

authors： Pessa-Morikawa T,Nordström T,Mustelin T,Andersson LC

更新日期：1991-07-15 00:00:00

abstract：:Data on a new entity which inhibits the release of luteinizing hormone (LH), designated as factor C-LHIH, are presented. In vitro assays were carried out with pituitary glands from female rats. Factor C-LHIH and follicle stimulating hormone releasing hormone (FSHRH) initially fractionated together. FSHRH obscured C...

journal_title：Biochemical and biophysical research communications

authors： Johansson KN,Greibrokk T,Currie BL,Hansen J,Folkers K

更新日期：1975-03-03 00:00:00

abstract：:Era is an essential G-protein in Escherichia coli identified originally as a homologue protein to Ras (E. coli Ras-like protein). It binds to GTP/GDP and contains a low intrinsic GTPase activity. Its function remains elusive, although it has been suggested that Era is associated with the cytoplasmic membrane, cell div...

journal_title：Biochemical and biophysical research communications

authors： Sayed A,Matsuyama Si,Inouye M

更新日期：1999-10-14 00:00:00

abstract：:Salmon calcitonin potently competes for amylin binding sites in rat brain and has amylin-like actions upon glucose metabolism in rat muscle. We report here that [125I]-salmon calcitonin binds to rat hindlimb muscle membranes with high affinity (Kd = 0.47 pM). Binding was inhibited by rat amylin (Ki = 2 nM), rat alpha ...

journal_title：Biochemical and biophysical research communications

authors： Kenney MA,Moore CX,Pittner R,Beaumont K

更新日期：1993-11-30 00:00:00

abstract：:Isoprenoids comprise a diverse group of natural products with a broad range of metabolic functions. Isoprenoids are synthesized from prenyl pyrophosphates by prenyltransferases that catalyze the isoprenoid chain-elongation process to different chain lengths. We hereby present the crystal structure of geranylgeranyl py...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Kim EJ,Park JB,Kim SW,Kim KJ

更新日期：2019-10-20 00:00:00

abstract：:Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on osteoclastogenesis remain to be elucidated. Therefore, we investigated the ...

journal_title：Biochemical and biophysical research communications

authors： Cai ZY,Yang B,Shi YX,Zhang WL,Liu F,Zhao W,Yang MW

更新日期：2018-09-05 00:00:00

abstract：:Vasectomy induces an immediate biophysical incompetence in epididymal spermatozoa in terms of the erroneous execution of membrane configuration processes, premature membrane melting and untimely protein gyration. Disturbances in the planned expression 'foreign proteins' and the possible 'swinging off' of these molecul...

journal_title：Biochemical and biophysical research communications

authors： Chatterjee S,Laloraya M,Kumar GP

更新日期：1993-12-15 00:00:00

abstract：:To analyse the species of genes expressed in a cleavage stage mouse embryo, we have constructed a cDNA library containing 3.0 x 10(5) independent clones from about 2 x 10(3) embryos at the 8-cell stage of development. Endo A cDNA prepared from parietal yolk sac endoderm like PYS-2 cells was used to screen the library....

journal_title：Biochemical and biophysical research communications

authors： Nozaki M,Murata K,Morita T,Matsushiro A

更新日期：1988-08-15 00:00:00

abstract：:Ribosome modulation factor (RMF) is involved in stabilization of ribosomes during the transition from exponential growth to the stationary growth phase in Escherichia coli. A deficiency of RMF is known to reduce cell viability. Overaccumulation of spermidine also leads to a decrease in cell viability and to a decrease...

journal_title：Biochemical and biophysical research communications

authors： Apirakaramwong A,Fukuchi J,Kashiwagi K,Kakinuma Y,Ito E,Ishihama A,Igarashi K

更新日期：1998-10-20 00:00:00

abstract：:Calcineurin Inhibitors (CNIs) are routinely used for immunosuppression following solid organ transplantation. However, the prolonged use of these agents lead to organ fibrosis which limits their efficacy. CNIs induce TGFβ expression, which is reported to augment endothelial-to-mesenchymal transition (EndMT), but their...

journal_title：Biochemical and biophysical research communications

authors： Woda CB,Bruneau S,Mak AL,Haskova Z,Liu K,Ghosh CC,Briscoe DM

更新日期：2019-11-19 00:00:00

abstract：:Myosin light-chain kinase (MLCK) of smooth muscle consists of an actin-binding domain at the N-terminal, the catalytic domain in the central portion, and the myosin-binding domain at the C-terminal. The kinase activity is mediated by the catalytic domain that phosphorylates the myosin light-chain of 20kDa (MLC20), act...

journal_title：Biochemical and biophysical research communications

authors： Nakamura A,Xie C,Zhang Y,Gao Y,Wang HH,Ye LH,Kishi H,Okagaki T,Yoshiyama S,Hayakawa K,Ishikawa R,Kohama K

更新日期：2008-04-25 00:00:00

abstract：:We have recently identified in porcine brain a series of new peptides, designated calcitonin receptor-stimulating peptide-1 (CRSP-1), CRSP-2, and CRSP-3, but failed to find their counterparts in humans and rodents by either database searching or experimental cross-hybridization. In this study, we isolated cDNAs encodi...

journal_title：Biochemical and biophysical research communications

authors： Katafuchi T,Hamano K,Minamino N

更新日期：2004-01-02 00:00:00

abstract：:Specific binding of [3H][D-Ala2,D-Leu5]enkephalin, [3H]ethylketocyclazocine, 5-[3H]hydroxytryptamine, and [3H]spiperone was examined in neuroblastoma-brain hybrid cell line NCB-20 following exposure to inhibitors of N-linked protein glycosylation (tunicamycin, TM) and oligosaccharide processing (swainsonine, SW). TM t...

journal_title：Biochemical and biophysical research communications

authors： McLawhon RW,Berry-Kravis E,Dawson G

更新日期：1986-02-13 00:00:00

abstract：:Leukotriene B(4) (LTB(4)) is a potent chemoattractant and activator of neutrophils, macrophages and T cells. These cells are a key component of inflammation and all express BLT1, a high affinity G-protein-coupled receptor for LTB(4). However, little is known about the neuroimmune functions of BLT1. In this study, we d...

journal_title：Biochemical and biophysical research communications

authors： Kihara Y,Yokomizo T,Kunita A,Morishita Y,Fukayama M,Ishii S,Shimizu T

更新日期：2010-04-09 00:00:00

abstract：:We propose that a substance, identified using mass spectrometry, present in the hemolymph of the honeybee (Apis mellifera) as a result of stimulating the insect immune system corresponds with Apidaecin I, an antibacterial peptide recently described. The plasma desorption mass spectra indicate that several other higher...

journal_title：Biochemical and biophysical research communications

authors： Craig AG,Trenczek T,Fries I,Bennich H

更新日期：1989-12-15 00:00:00

abstract：:This paper reports the identification of a Rho family nucleotide exchange factor termed mNET1 as a candidate-interacting partner for the first PDZ domain of MAGI-1, a membrane-associated guanylate kinase with inverted arrangement of protein-protein interacting modules. mNET1 was identified in a yeast two-hybrid screen...

journal_title：Biochemical and biophysical research communications

authors： Dobrosotskaya IY

更新日期：2001-05-18 00:00:00

abstract：:Prior studies have identified molecules involved in IL-1 signaling that transmit the extracellular stimulus to downstream kinase molecules causing altered transcriptional activity. Many of these investigations have relied heavily on ligand induced protein-protein interactions detected by immuno-coprecipitation to map ...

journal_title：Biochemical and biophysical research communications

authors： Boch JA,Yoshida Y,Koyama Y,Wara-Aswapati N,Peng H,Unlu S,Auron PE

更新日期：2003-04-04 00:00:00

abstract：:Sf9 cells infected with the recombinant mouse CaMKII-alpha (Ca2+/calmodulin dependent kinase II) baculovirus expressed 12-15 mg of MCaMKII-alpha per liter of cells. Approximately 50% of the MCaMKII-alpha activity could be purified using a CaM-Sepharose affinity column. The purified MCaMKII-alpha had a M(rapp) of 50 kD...

journal_title：Biochemical and biophysical research communications

authors： Brickey DA,Colbran RJ,Fong YL,Soderling TR

更新日期：1990-12-14 00:00:00

abstract：:Oxidative damage to DNA has been reported to occur in a wide variety of disease states. The most widely used "marker" for oxidative DNA damage is 8-hydroxyguanine. However, the use of only one marker has limitations. Exposure of calf thymus DNA to an .OH-generating system (CuCl(2), ascorbate, H(2)O(2)) or to hypochlor...

journal_title：Biochemical and biophysical research communications

authors： Whiteman M,Hong HS,Jenner A,Halliwell B

更新日期：2002-08-30 00:00:00

abstract：:Available evidence suggests that insulin-like growth factor I receptor (IGF-IR) expression leads to increased cellular radioresistance. The most direct explanation of these findings predicts that IGF-IR is the source of survival signals in resistant cells. Mutational analysis revealed that protein truncated at amino a...

journal_title：Biochemical and biophysical research communications

authors： Yu D,Shibuya H,Miura M

更新日期：2003-11-07 00:00:00

abstract：:Calpain was generally believed to exist and function only in the cytoplasm. However, m-calpain has now been detected in the extracellular spaces of some kinds of tissue. In this study, we demonstrated the existence of m-calpain in the medium surrounding MC3T3-E1 cultures, and its activity by zymography. At the same ti...

journal_title：Biochemical and biophysical research communications

authors： Nishihara H,Nakagawa Y,Ishikawa H,Ohba M,Shimizu K,Nakamura T

更新日期：2001-07-20 00:00:00