当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP.

Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP.

Abstract：

:The tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors of MMP enzymatic activity. However, TIMP-2 can promote the activation of pro-MMP-2 by MT1-MMP. This process is mediated by the formation of a complex between MT1-MMP, TIMP-2, and pro-MMP-2. Binding of TIMP-2 to active MT1-MMP also inhibits the autocatalytic turnover of MT1-MMP on the cell surface. Thus, under certain conditions, TIMP-2 is a positive regulator of MMP activity. TIMP-4, a close homologue of TIMP-2 also binds to pro-MMP-2 and can potentially participate in pro-MMP-2 activation. We coexpressed MT1-MMP with TIMP-4 and investigated its ability to support pro-MMP-2 activation. TIMP-4, unlike TIMP-2, does not promote pro-MMP-2 activation by MT1-MMP. However, TIMP-4 binds to MT1-MMP inhibiting its autocatalytic processing. When coexpressed with TIMP-2, TIMP-4 competitively reduced pro-MMP-2 activation by MT1-MMP. A balance between TIMP-2 and TIMP-4 may be a critical factor in determining the degradative potential of cells in normal and pathological conditions.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hernandez-Barrantes S,Shimura Y,Soloway PD,Sang QA,Fridman R

doi

10.1006/bbrc.2001.4323

subject

Has Abstract

pub_date

2001-02-16 00:00:00

pages

126-30

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)94323-2

journal_volume

281

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Intracellular calcium levels can regulate Importin-dependent nuclear import.

    abstract：:We previously showed that increased intracellular calcium can modulate Importin (Imp)β1-dependent nuclear import of SRY-related chromatin remodeling proteins. Here we extend this work to show for the first time that high intracellular calcium inhibits Impα/β1- or Impβ1-dependent nuclear protein import generally. The b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.06.047

    authors： Kaur G,Ly-Huynh JD,Jans DA

    更新日期：2014-07-18 00:00:00

  • Tooth regeneration from newly established cell lines from a molar tooth germ epithelium.

    abstract：:In order to investigate tooth development, several cell lines of the dental epithelium and ectomesenchyme have been established. However, no attempt has been reported to regenerate teeth with cell lines. Here, we have established several clonal cell lines of the dental epithelium from a p53-deficient fetal mouse. They...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.02.039

    authors： Komine A,Suenaga M,Nakao K,Tsuji T,Tomooka Y

    更新日期：2007-04-13 00:00:00

  • Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.

    abstract：:RAB3A interacting protein (Rab3IP) has been determined to be involved in cancer progression; however, its expression pattern and function in gastric cancer remain unknown. The aim of this study was to determine the association between Rab3IP and gastric cancer, in addition to its functional role in this disease. Overe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.07.016

    authors： Ren H,Xu Z,Guo W,Deng Z,Yu X

    更新日期：2018-09-18 00:00:00

  • Purification and identification of endogenous anti-opioid substances from bovine brain.

    abstract：:Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction was [Val5]-angiotensin II, a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90646-1

    authors： Kaneko S,Tamura S,Takagi H

    更新日期：1985-01-16 00:00:00

  • Possible participation of calmodulin in stimulation of leucine transport by concanavalin A in human lymphocytes.

    abstract：:Stimulation of leucine uptake by addition of concanavalin A, mediated by increase of intracellular free Ca2+ concentration [( Ca2+]), in lymphocytes (Mitsumoto, Y., Sato, K. and Mohri, T. (1988) Biochim. Biophys. Acta 968, 353-358) was abolished by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and chlorprom...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81133-1

    authors： Sato K,Mitsumoto Y,Mohri T

    更新日期：1988-06-16 00:00:00

  • 2-Deoxy-d-glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N-glycosylation in pancreatic cancer cells.

    abstract：:The glycolytic inhibitor 2-deoxy-d-glucose (2DG) causes energy starvation, affecting cell viability in a wide range of cancer cell lines. To determine the action of 2DG in pancreatic cancer, we performed proteomic analysis of pancreatic cancer cell line after 2DG treatment. Eighty proteins showed differential expressi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.041

    authors： Ishino K,Kudo M,Peng WX,Kure S,Kawahara K,Teduka K,Kawamoto Y,Kitamura T,Fujii T,Yamamoto T,Wada R,Naito Z

    更新日期：2018-06-27 00:00:00

  • Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes.

    abstract：:VHL tumor suppressor protein contains two domains, alpha and beta. The alpha-domain is involved in the formation of a large protein complex suggested to be involved in ubiquitin-mediated protein degradation. However, the role of the beta-domain, which may recognize the target proteins for protein degradation, remains ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1347

    authors： Okuda H,Hirai S,Takaki Y,Kamada M,Baba M,Sakai N,Kishida T,Kaneko S,Yao M,Ohno S,Shuin T

    更新日期：1999-09-24 00:00:00

  • Measurement of nitric oxide release in the isolated perfused rat lung.

    abstract：:In this study we have continuously measured real-time production of nitric oxide (NO) in the isolated, perfused rat lung by using an NO monitor (model NO-501, Inter Medical Co., Nagoya, Japan) with an NO-selective resin microsensor. A stable NO response was obtained when the sensor was placed in the pulmonary artery o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1435

    authors： Wang D,Hsu K,Hwang CP,Chen HI

    更新日期：1995-03-28 00:00:00

  • Site-directed mutagenesis of a novel serine arylesterase from Vibrio mimicus identifies residues essential for catalysis.

    abstract：:Site-directed mutagenesis (SDM) of an arylesterase (the arylesterase) from Vibrio mimicus revealed that residues S29, H153, and D96 constituted a catalytic triad. The use of a serine residue for ester hydrolysis by the arylesterase proves that the enzyme is a novel serine arylesterase. SDM also showed that D28 was nec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0620

    authors： Chang RC,Chen JC,Shaw JF

    更新日期：1996-04-16 00:00:00

  • Use of 1-4 interaction scaling factors to control the conformational equilibrium between α-helix and β-strand.

    abstract：:1-4 interaction scaling factors are used in AMBER forcefields to reduce the exaggeration of short-range repulsion caused by the 6-12 Lennard-Jones potential and a nonpolarizable charge model and to obtain better agreements of small-molecule conformational energies with experimental data. However, the effects of these ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.12.084

    authors： Pang YP

    更新日期：2015-02-06 00:00:00

  • Effect of ELOVL3 expression on bovine skeletal muscle-derived satellite cell differentiation.

    abstract：:ELOVL3 is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment. In addition, ELOVL3 is related to increased fatty acid oxidation in brown adipocytes. However, the potential functions of ELOVL3 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.07.118

    authors： Liu D,Xu JH,Tong HL,Li SF,Yan YQ

    更新日期：2017-12-02 00:00:00

  • Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5.

    abstract：AIMS:New Zealand obese (NZO) mice exhibit a polygenic syndrome of obesity, insulin resistance, and hypercholesterolemia that resembles the human metabolic syndrome. This study was performed in order to locate genes responsible for elevated serum cholesterol and to compare their effects under a standard and high fat die...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00664-8

    authors： Giesen K,Plum L,Kluge R,Ortlepp J,Joost HG

    更新日期：2003-05-16 00:00:00

  • Regulation of c-myc through intranuclear localization of its RNA subspecies.

    abstract：:We used fluorescence in situ hybridization (FISH) to detect c-myc RNA subspecies in human COLO 320DM tumor cells. Although the FISH procedure removed the majority of RNAs from the nucleolus, c-myc RNA continued to be detected in both the nucleoplasm and nucleolus. This finding suggests stable association between c-myc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.201

    authors： Shimizu N,Kawamoto JK,Utani K

    更新日期：2007-08-03 00:00:00

  • Cisplatin induced alterations in oriented fibers of DNA studied by atomic force microscopy.

    abstract：:Oriented fibers of DNA, prepared by the wet spin method, were imaged by atomic force microscopy. It was found that an oriented fiber's substructure is an array of assemblages of DNA. For native DNA, the assemblages exhibit a characteristic width of 76 nm, a thickness of 20 nm, and appear to carry a right handed twist....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80131-7

    authors： Rampino NJ

    更新日期：1992-01-15 00:00:00

  • Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases.

    abstract：:CD24 is a differentiation antigen expressed by murine hematopoietic and neural cells which is linked to the membrane via a glycosylphosphatidylinositol (GPI) anchor. In monocytic ESb-MP cells the molecule serves as a ligand for P-selectin and triggering with CD24 specific antibodies can activate VLA-5/L1-mediated cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6639

    authors： Sammar M,Gulbins E,Hilbert K,Lang F,Altevogt P

    更新日期：1997-05-19 00:00:00

  • Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss.

    abstract：:The mechanisms underlying diabetes-mediated bone loss are not well defined. It has been reported that the advanced glycation endproducts (AGEs) and receptor for AGEs (RAGEs) are involved in diabetic complications. Here, mice deficient in RAGE were used as a model for investigating the effects of RAGE on bone mass. We ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.107

    authors： Ding KH,Wang ZZ,Hamrick MW,Deng ZB,Zhou L,Kang B,Yan SL,She JX,Stern DM,Isales CM,Mi QS

    更新日期：2006-02-24 00:00:00

  • Differential regulation of Na(v)beta subunits during myogenesis.

    abstract：:Voltage-gated sodium channels (Na(v)) consist of a pore-forming alpha subunit (Na(v)alpha) associated with beta regulatory subunits (Na(v)beta). Adult skeletal myocytes primarily express Na(v)1.4 channels. We found, however, using neonatal L6E9 myocytes, that myofibers acquire a Na(v)1.5-cardiac-like phenotype efficie...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.01.138

    authors： David M,Martínez-Mármol R,Gonzalez T,Felipe A,Valenzuela C

    更新日期：2008-04-11 00:00:00

  • Germ cell nuclear factor is a response element-specific repressor of transcription.

    abstract：:We have shown that the orphan receptor Germ Cell Nuclear Factor (GCNF) binds to a direct repeat of the sequence AGGTCA with zero base pair spacing (DR0). Here, we further characterize the binding characteristics of GCNF. We demonstrate that GCNF binds specifically to DR0s as a homodimer, and does not bind with high af...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8391

    authors： Cooney AJ,Hummelke GC,Herman T,Chen F,Jackson KJ

    更新日期：1998-04-07 00:00:00

  • Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions.

    abstract：:Septins, a conserved family of GTPases, are heteropolymeric filament-forming proteins that associate with the cell membrane and cytoskeleton and serve essential functions in cell division and morphogenesis. Their roles in fungal cell wall chitin deposition, septation, cytokinesis, and sporulation have been well establ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.01.017

    authors： Juvvadi PR,Fortwendel JR,Rogg LE,Steinbach WJ

    更新日期：2011-02-11 00:00:00

  • DNA induces apoptosis in electroporated human promonocytic cell line U937.

    abstract：:Experimental gene transfer has permitted a wide variety of studies on gene regulation and function. However, possible effects of the introduced DNA on cellular metabolism are not well understood. Here we demonstrated that introduction of DNA into a promonocytic cell line, U937, by electroporation caused extensive cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2388

    authors： Shimokawa T,Okumura K,Ra C

    更新日期：2000-04-02 00:00:00

  • alphaA- and alphaB-crystallins protect glucose-6-phosphate dehydrogenase against UVB irradiation-induced inactivation.

    abstract：:alpha-Crystallin, a major eye lens protein, has been shown to function like a molecular chaperone by suppressing the aggregation of other proteins induced by various stress conditions. Ultraviolet (UV) radiation is known to cause structural and functional alterations in the lens macromolecules. Earlier we observed tha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4642

    authors： Reddy GB,Reddy PY,Suryanarayana P

    更新日期：2001-04-06 00:00:00

  • Palmitate activates AMP-activated protein kinase and regulates insulin secretion from beta cells.

    abstract：:AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. Changes in AMPK activity contribute to the regulation of insulin secretion. Epidemiological evidence links the ingestion of saturated fatty acid with hyperinsulinemia. The aim of the present study was to examine the effects of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.032

    authors： Wang X,Zhou L,Li G,Luo T,Gu Y,Qian L,Fu X,Li F,Li J,Luo M

    更新日期：2007-01-12 00:00:00

  • Identification and distribution of endoplasmic reticulum iPLA2.

    abstract：:Our laboratory demonstrated that endoplasmic reticulum iPLA2 (ER-iPLA2) activity protects renal cells from oxidant-induced cell death and lipid peroxidation. The goals of this study were to determine the PLA2 isoform(s) responsible for ER-iPLA2 activity in different species and tissues. ER-iPLA2 activity was observed ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.12.016

    authors： Kinsey GR,Cummings BS,Beckett CS,Saavedra G,Zhang W,McHowat J,Schnellmann RG

    更新日期：2005-02-04 00:00:00

  • Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks.

    abstract：:Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the ph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.03.063

    authors： Bobeck EA,Burgess KS,Jarmes TR,Piccione ML,Cook ME

    更新日期：2012-04-13 00:00:00

  • Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part I: Modulation of adenylate cyclase activity.

    abstract：:In the present study we evaluated the effect of interleukin 1-beta on adenylate cyclase activity in 235-1 pituitary cell line. The dose-response curve of interleukin 1 beta effect on adenylate cyclase activity showed a significant inhibition of basal enzyme activity at 1 pM concentration, while the inhibition of forsk...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81252-x

    authors： Schettini G,Florio T,Meucci O,Scala G,Landolfi E,Grimaldi M

    更新日期：1988-09-30 00:00:00

  • Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia.

    abstract：:The cardiovascular system operates under demands ranging from conditions of rest to extreme stress. One mechanism of cardiac stress tolerance is action potential duration shortening driven by ATP-sensitive potassium (K(ATP)) channels. K(ATP) channel expression has a significant physiologic impact on action potential d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.10.125

    authors： Zhu Z,Burnett CM,Maksymov G,Stepniak E,Sierra A,Subbotina E,Anderson ME,Coetzee WA,Hodgson-Zingman DM,Zingman LV

    更新日期：2011-12-02 00:00:00

  • Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression.

    abstract：:Photoreceptor-specific gene expression is controlled by a hierarchical network of transcription factors, including the master regulators cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl). Myocyte-enhancer factor 2c (Mef2c) is an ubiquitously expressed transcription factor with important functions in the c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.12.141

    authors： Wolf A,Aslanidis A,Langmann T

    更新日期：2017-01-29 00:00:00

  • Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.

    abstract：:Action of protein kinases and phosphatases contributes to myocardial hypertrophy. PRL-3, a protein tyrosine phosphatase, was identified in a cDNA library from an explanted human heart obtained from a patient with idiopathic cardiomyopathy. PRL-3 is expressed in heart and skeletal muscle, exhibiting approximately 76% i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4881

    authors： Matter WF,Estridge T,Zhang C,Belagaje R,Stancato L,Dixon J,Johnson B,Bloem L,Pickard T,Donaghue M,Acton S,Jeyaseelan R,Kadambi V,Vlahos CJ

    更新日期：2001-05-25 00:00:00

  • Effect of staurosporine on the transcription of HSP70 heat shock gene in HT-29 cells.

    abstract：:We have investigated the effects of staurosporine (STP), an inhibitor of PKC, on the expression of the HSP70 gene in human colon carcinoma HT-29 cells. Cells were heated at 45 degrees C for 15 min and incubated at 37 degrees C for up to 6 hr with or without STP. When STP (5 micrograms/ml) was added during 37 degrees C...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1953

    authors： Erdos G,Lee YJ

    更新日期：1994-07-15 00:00:00

  • Hemoglobin M: effect of the proximal or distal histidine replacement on circular dichroism in the visible region.

    abstract：:To examine the effects of a replacement of the proximal or the distal histidine on the structure of hemoglobin (Hb), absorption and circular dichroic (CD) spectra of five species of Hbs M in the visible region were measured. Four Hbs M had a characteristic but a similar absorption spectrum upon amino acid substitution...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90101-9

    authors： Nagai M,Takama S,Yoneyama Y

    更新日期：1985-04-30 00:00:00