当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine.

Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine.

Abstract：

:We recently showed that alpha4beta1 integrin induces B-cell chronic lymphocytic leukemia (B-CLL) cell resistance to fludarabine-induced apoptosis via upregulation of Bcl-xL. We have now studied whether p53 was involved in this response. Cells from five B-CLL patients with wild-type p53 determined by DNA sequencing, or from the EHEB cell line, cultured on the alpha4beta1 ligand H/89 during fludarabine treatment, showed significantly higher viability (P

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

de la Fuente MT,Casanova B,Cantero E,Hernández del Cerro M,Garcia-Marco J,Silva A,Garcia-Pardo A

doi

10.1016/j.bbrc.2003.10.054

subject

Has Abstract

pub_date

2003-11-21 00:00:00

pages

708-12

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03021387

journal_volume

311

pub_type

杂志文章

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